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【medical-news】前列腺癌放疗后出现肥胖可能意味
Obesity Predicts Prostate Cancer Recurrence After Radiation Therapy
NEW YORK (Reuters Health) Aug 20 - Obese men have an increased risk of biochemical recurrence of prostate cancer and disease-specific death after radiation therapy, according to results of a study published in the August issue of BJU International.
"Obesity has been demonstrated to predict biochemical progression in men undergoing radical prostatectomy for prostate adenocarcinoma," write Dr. David Palma and colleagues from the British Columbia Cancer Agency, Vancouver, Canada.
The researchers examined whether obesity is associated with outcomes in patients who underwent external beam radiation therapy for prostate cancer. Of 706 patients treated with radiation from 1994 through 2000, 195 were normal weight, 358 were overweight, and 153 were obese.
There were no significant differences between BMI groups in Gleason score, pretreatment PSA, or stage. Serum testosterone levels were lower in obese men than in overweight and normal-weight men.
There were a total of 292 biochemical failure events in the cohort. The median times to biochemical relapse for normal-weight, overweight, and obese men were 93 months, 88 months, and 84 months, respectively.
The median times to prostate-cancer specific death were 11.1 years for normal and overweight men, and 10.6 years for obese men (p = 0.01). Results of multivariate analysis revealed a trend toward decreased overall survival by BMI group.
"A number of explanations have been postulated to account for more aggressive prostate cancer in obese men," Dr. Palma and colleagues note. "Possible mechanisms include dietary factors and alterations in hormonal levels, such as estrogens, androgens, leptin, and IGF-1, although definitive mechanisms have not been elucidated." BJU Int 2007;100:315-319.
Obesity Predicts Prostate Cancer Recurrence After Radiation Therapy
前列腺癌症患者放疗后肥胖预示复发。
NEW YORK (Reuters Health) Aug 20 - Obese men have an increased risk of biochemical recurrence of prostate cancer and disease-specific death after radiation therapy, according to results of a study published in the August issue of BJU International.
纽约（路透社健康频道）8月20日 ： BJU International杂志8月发表了文章，指出肥胖前列腺癌症患者放疗出现生物学复发的危险性以及疾病相关的死亡率增加。
"Obesity has been demonstrated to predict biochemical progression in men undergoing radical prostatectomy for prostate adenocarcinoma," write Dr. David Palma and colleagues from the British Columbia Cancer Agency, Vancouver, Canada.
“肥胖已经被用来预测接受前列腺切除术的前列腺癌症患者生物学进展”，来自于加拿大的英国哥伦比亚癌症中心的David Palma博士和他的同事这样说道。
The researchers examined whether obesity is associated with outcomes in patients who underwent external beam radiation therapy for prostate cancer. Of 706 patients treated with radiation from 1994 through 2000, 195 were normal weight, 358 were overweight, and 153 were obese.从1994年到2000年有706名患者接受了放疗，195名患者是正常体重，358名患者是超重，153名患者是肥胖，研究人员观察了肥胖是否对接受放疗的前列腺癌症患者的预后有影响。
There were no significant differences between BMI groups in Gleason score, pretreatment PSA, or stage. Serum testosterone levels were lower in obese men than in overweight and normal-weight men.
结果发现在不同体重指数组中，Gleason 积分、前列腺特异抗原、分期均没有显著性差异；而血清睾酮水平在肥胖组中显著低于超重组和正常体重组。
There were a total of 292 biochemical failure events in the cohort. The median times to biochemical relapse for normal-weight, overweight, and obese men were 93 months, 88 months, and 84 months, respectively.
在随访结果中，有292名患者失访，生物学复发的平均时间在正常体重组、超重组和肥胖组中分别为93月、88月和84月。
The median times to prostate-cancer specific death were 11.1 years for normal and overweight men, and 10.6 years for obese men (p = 0.01). Results of multivariate analysis revealed a trend toward decreased overall survival by BMI group.
前列腺导致的死亡中位时间在正常体重组为11.1年，肥胖组为10.6年（P=0.01）。多变量分析结果表明随着体重的增加，总体生存期有减少的趋势。
"A number of explanations have been postulated to account for more aggressive prostate cancer in obese men," Dr. Palma and colleagues note. "Possible mechanisms include dietary factors and alterations in hormonal levels, such as estrogens, androgens, leptin, and IGF-1, although definitive mechanisms have not been elucidated."
“有很多的假说来试图解释肥胖人群中前列腺癌更具有侵袭性，”Palma博士和他的同事指出，“尽管还没有确切的机制，其中可能的机制包括了饮食因素和紊乱的激素水平，比如雌激素,雄激素,瘦素以及胰岛素样生长因子。”
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作者:admin@医学,生命科学 2011-02-15 17:12
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