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【medical-news】疱疹病毒是如何躲过免疫系统感染
Herpes virus has an unusual strategy for infecting cornea cells that may also explain how it evades the immune system, according to a study by researchers at the University of Illinois at Chicago College of Medicine.
The study appears in the Sept. 25 issue of the Journal of Cell Biology.
Both strains of the herpes virus -- HSV-1, the strain that causes cold sores on the mouth, and HSV-2, genital herpes -- can infect the cornea, the clear, domed surface that forms the eye's outermost layer. Ocular herpes is the leading cause of infectious blindness in the United States, with 50,000 new or recurring cases each year.
In about one quarter of cases, the virus penetrates the first layer of the cornea to infect an inner layer, the stroma, making the disease much more difficult to treat.
Effective treatment is hampered by poor understanding of how the virus infects the stroma, says Deepak Shukla, assistant professor of ophthalmology and visual science and microbiology and immunology, and senior author of the paper. In their study, he and his coworkers determined that the HSV-1 virus enters stroma cells in a process similar to the way bacteria, viruses and other foreign invaders are engulfed by immune cells called phagocytes.
"In the electron microscope pictures, it looks like the stroma cells form long arms that reach out and collect the virus particles, and then wrap around them, forming a sac, and bring them into the cell body," Shukla said.
In phagocytes, ingested foreign particles are destroyed in the sacs, which are highly acidic. But even though the sacs formed by the stroma cells were similar to the phagocyte's sacs, Shukla said, the envelope containing the herpes virus genome emerges from the sac undamaged and able to infect the cell. "This raises the interesting possibility that herpes may be able to evade the immune system defenses in the same way," he said.
"Understanding herpes' unusual pathway for infecting the stroma cells opens up new strategies for developing therapies against this potentially blinding disease and has implications for understanding other herpes virus infections," Shukla said. 认领了 第一次试译，不知怎么操作，来试试 Study shows how herpes infects cornea, evades immune cells
Herpes virus has an unusual strategy for infecting cornea cells that may also explain how it evades the immune system, according to a study by researchers at the University of Illinois at Chicago College of Medicine.
研究揭示了疱疹病毒如何逃避免疫细胞感染角膜的
据伊利诺斯州大学和芝加哥大学医学院的研究者研究，疱疹病毒具有感染角膜细胞的不寻常机制，这或许能揭示疱疹病毒逃避免疫系统的方式。
The study appears in the Sept. 25 issue of the Journal of Cell Biology.
这一研究发表在细胞生物学杂志（Journal of Cell Biology）9.25日这一期。
Both strains of the herpes virus -- HSV-1, the strain that causes cold sores on the mouth, and HSV-2, genital herpes -- can infect the cornea, the clear, domed surface that forms the eye's outermost layer. Ocular herpes is the leading cause of infectious blindness in the United States, with 50,000 new or recurring cases each year.
两株疱疹病毒：引起口唇剧痛的单纯疱疹病毒I型（HSV-1），和Ⅱ型生殖器疱疹HSV-2，都能感染角膜——眼睛最外层的透明的、半球形表面组织。在美国，眼睛疱疹病毒是引起感染性失明的首要原因，每年有5万新的感染或复发病例。
In about one quarter of cases, the virus penetrates the first layer of the cornea to infect an inner layer, the stroma, making the disease much more difficult to treat.
四分之一的病例中，病毒穿过最外层角膜感染内层基质，使得疾病更难于治疗。
Effective treatment is hampered by poor understanding of how the virus infects the stroma, says Deepak Shukla, assistant professor of ophthalmology and visual science and microbiology and immunology, and senior author of the paper. In their study, he and his coworkers determined that the HSV-1 virus enters stroma cells in a process similar to the way bacteria, viruses and other foreign invaders are engulfed by immune cells called phagocytes.
论文第一作者，眼科视觉科学与微生物免疫学副教授Deepak Shukla说，由于不了解疱疹病毒如何感染基质，所以对（疱疹病毒感染内层基质）很难采取有效治疗措施。本研究中，他与同事确定了HSV-1进入基质细胞的过程，类似于细菌、病毒和其他病原被称为巨噬细胞的免疫细胞吞噬的过程。
"In the electron microscope pictures, it looks like the stroma cells form long arms that reach out and collect the virus particles, and then wrap around them, forming a sac, and bring them into the cell body," Shukla said.
Shukla 说：“在电镜照片中，看起来像是基质细胞伸开长臂，收集病毒粒子并包裹他们，形成包囊，从而将病毒带入细胞。”
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作者:admin@医学,生命科学 2010-12-24 05:11
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