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【medical-news】低睾酮水平的老龄男性更容易跌倒
Falls More Likely In Elderly Men With Low Testosterone Levels
Low testosterone levels may be associated with a higher risk of falling in older men, according to a report in the October 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
The level of testosterone in a man's blood--including the amount that is bioavailable, or able to be used by the body--declines as he ages, according to background information in the article. Some researchers have speculated that this decline in sex hormone levels contributes to health conditions associated with aging; however, few studies support this notion. Muscle weakness and muscle loss are two adverse events that often occur with age and are known to increase the risk of falling among older adults.
Eric Orwoll, M.D., Oregon Health & Science University, Portland, and colleagues studied 2,587 men age 65 to 99 (average age 73) who enrolled in the Osteoporotic Fractures in Men (MrOS) Study between 2000 and 2002. At the beginning of the study, blood samples were taken and participants filled out questionnaires about their medical history, medications and lifestyle habits. The men completed several physical performance tests, including those assessing grip strength, leg power and balance. Every four months, they reported whether they had fallen and if so, how many times.
During the course of the study, which continued until March 2005, 56 percent of the men fell at least once. Those with lower bioavailable testosterone levels were significantly more likely to fall and to fall multiple times than those with higher levels--among the one-fourth of participants with the lowest testosterone levels, the risk for falling was 40 percent higher than among the one-fourth with the highest testosterone levels. The association was stronger in younger men (ages 65 to 69) and not apparent in men older than 80.
The association remained the same when the researchers factored in the scores on physical performance tests.
"Bioavailable testosterone concentration is associated with measures of physical performance, but the association of testosterone level to the risk of falling is apparent regardless of physical performance," the authors write. "Thus, the mechanisms by which testosterone level affects the propensity to fall may involve other pathways." For example, low testosterone levels could impair vision, thinking processes or coordination, increasing the risk for falls.
"These findings strengthen the link between testosterone and the health of older men, suggesting that the effects of testosterone on fall risk may be via novel mechanisms and provide insight into how testosterone measurements might be useful for identifying men at higher risk for adverse events," the authors conclude. "Moreover, these results provide additional justification for trials of testosterone supplementation in older men and should aid in the design of those studies." 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Falls More Likely In Elderly Men With Low Testosterone Levels
低睾酮水平的老龄男性更容易跌倒
Low testosterone levels may be associated with a higher risk of falling in older men, according to a report in the October 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
据美国医学协会杂志之一《内科学档案》10月23日刊的一份报告称，睾酮水平低可能与老年人跌倒风险升高有关。
The level of testosterone in a man's blood--including the amount that is bioavailable, or able to be used by the body--declines as he ages, according to background information in the article. Some researchers have speculated that this decline in sex hormone levels contributes to health conditions associated with aging; however, few studies support this notion. Muscle weakness and muscle loss are two adverse events that often occur with age and are known to increase the risk of falling among older adults.
根据文章的背景知识，睾酮在男性血液中的水平－包括其有生物活性的数量，或者说是可以被机体利用的数量－随着年龄的增长在下降。一些研究人员已经推测这种性激素水平的降低对健康状况随着年龄的增加而变差起很大的作用；然而，支持这一观点的研究很少。肌无力和肌力的丧失是两个有害的因素，它们常常会随着年龄的增长而出现，而且众所周知它们增加了老年人跌倒的危险性。
Eric Orwoll, M.D., Oregon Health & Science University, Portland, and colleagues studied 2,587 men age 65 to 99 (average age 73) who enrolled in the Osteoporotic Fractures in Men (MrOS) Study between 2000 and 2002. At the beginning of the study, blood samples were taken and participants filled out questionnaires about their medical history, medications and lifestyle habits. The men completed several physical performance tests, including those assessing grip strength, leg power and balance. Every four months, they reported whether they had fallen and if so, how many times.
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作者:admin@医学,生命科学 2010-10-23 05:11
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