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【Cell】为什么我们这么容易发胖？因为我们的爹
链接
http://www.cell.com/retrieve/pii/S0092867410014261
Summary
Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Offspring of males fed a low-protein diet exhibited elevated hepatic expression of many genes involved in lipid and cholesterol biosynthesis and decreased levels of cholesterol esters, relative to the offspring of males fed a control diet. Epigenomic profiling of offspring livers revealed numerous modest (?20%) changes in cytosine methylation depending on paternal diet, including reproducible changes in methylation over a likely enhancer for the key lipid regulator Ppara. These results, in conjunction with recent human epidemiological data, indicate that parental diet can affect cholesterol and lipid metabolism in offspring and define a model system to study environmental reprogramming of the heritable epigenome.
图片
Figure 1 A Screen for Genes Regulated by Paternal Diet
(A) Experimental design. Male mice were fed control or low (11%) protein diet from weaning until sexual maturity, then were mated to females that were raised on control diet. Males were removed after 1 or 2 days of mating. Livers were harvested from offspring at 3 weeks, and RNA was prepared, labeled, and hybridized to oligonucleotide microarrays.
( Overview of microarray data, comparing offspring of sibling males fed different diets—red boxes indicate higher RNA levels in low-protein than control offspring, green indicates higher expression in controls. Boxes at the top indicate comparisons between two male (purple) or two female (yellow) offspring. Each column shows results from a comparison of a pair of offspring. Only genes passing the stringent threshold for significant change (Figure S1 are shown. Data are clustered by experiment (columns) and by genes (rows).
(C) Validation of microarray data. Quantitative RT-PCR was used to determine levels of Squalene epoxidase (Sqle) relative to the control gene Vitronectin (Vtn), which showed no change in the microarray dataset. Animals are grouped by paternal diet and by sex, and data are expressed as ΔCT between Sqle and Vtn, normalized relative to the average of control females.
我的评
1
推荐的原因是，之前这个文章 父母的饮食习惯会影响到子女Parents Shape Whether Their Children Learn To Eat Fruits And Vegetables 讲的是，爹妈吃的肥，子女跟着胖。
http://news.dxy.cn/bbs/topic/12523305
2
而此文讲的是，父母总挨饿，处于进化学角度，子代更容易囤积脂肪来应付严酷的饥饿环境。也就是说，爸妈吃不饱，子女易发胖。
*节食的雄鼠在会影响后代的基因表达
*低蛋白饮食的动物子代胆固醇合成基因表达上调
*父亲的饮食会影响后代的肝脏的胆固醇酯水平
*部分机理是激活Pparα甲基化。
想到我娘当年指着我的肥肉说，“老娘当年吃不饱，你这个年纪只有80多斤，哪像你这个180斤的样子！”我终于可以拿着IF巨高的Cell砸她的话“正是因为你当年饿的，搞的我现在这么肥！达尔文都解决不了的问题，莫再烦我！”
3
PAPER都说了，爹妈吃饱了子女会肥，爹妈挨饿子女会肥，爹妈减肥子女会肥～～可见，人类是注定要肥的。既然我们是要注定发胖的，为了后代着想，也不要过于减肥了。省得儿女到时候减肥更辛苦。
reference
http://news.dxy.cn/bbs/topic/12523305
http://www.sciencedaily.com/releases/2008/08/080811200425.htm
http://www.cell.com/retrieve/pii/S0092867410014261#Introduction
http://news.dxy.cn/bbs/topic/12112032
全文见附件
PIIS0092867410014261.pdf (2041.46k) 在线查看
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作者:admin@医学,生命科学 2010-12-25 12:22
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