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【drug-news】Alefacept 治疗头皮银屑病有效
By Will Boggs, MD
NEW YORK (Reuters Health) May 01 - Alefacept, an immunomodulatory biologic agent that targets T cells, is effective in treating scalp psoriasis in adults, according to a report in the April issue of the Journal of the American Academy of Dermatology.
"Alefacept works as well in scalp psoriasis as it does in generalized body psoriasis," Dr. James Krell from Total Skin and Beauty Dermatology Center, Birmingham, Alabama told Reuters Health.
Dr. Krell and colleagues evaluated the safety and efficacy of alefacept in treating scalp psoriasis in 30 adults, all of whom received 16 once-weekly 15-mg intramuscular doses followed by a 12-week rest period. Those who did not achieve clearing received a second course of treatment.
Five patients (16.7%) achieved treatment success at week 6 after the first course of treatment, the authors report, and an additional 5 patients achieved treatment success 6 weeks after the second course of treatment.
A total of 16 patients (8 after each course of treatment) experienced at least a 75% reduction in their scalp psoriasis area and severity index, the researchers note, and 14 patients (7 after each course of treatment) rated themselves as much improved after treatment.
Only 1 patient reported treatment-related adverse events, including nausea, malaise, and gastrointestinal upset, and no patients withdrew from the study or missed doses because of low CD4+ T lymphocyte counts.
"It is always worth keeping alefacept in mind for the right patient when a very safe biologic medication is needed," Dr. Krell concluded. "As in other forms of psoriasis, alefacept is a third-line drug for me. As far as biologics go, I tend to use either an anti-TNF or Raptiva (efalizumab) before alefacept."
J Am Acad Dermatol 2008;58:609-616.
http://www.medscape.com/viewarticle/573848 本人已认领该文翻译，48小时后若未提交译文，请其他战友自由认领 Alefacept Effective for Treating Scalp Psoriasis
alefacept对头皮银屑病有效
By Will Boggs, MD
NEW YORK (Reuters Health) May 01
Will Boggs，MD
纽约（路透社，健康报）2008－05－01
Alefacept, an immunomodulatory biologic agent that targets T cells, is effective in treating scalp psoriasis in adults, according to a report in the April issue of the Journal of the American Academy of Dermatology.
4月份的美国皮肤病学学会杂志的一篇文章报道：作用于T细胞的免疫调节生物制剂Alefacept 对于成人银屑病的治疗是有效的。
"Alefacept works as well in scalp psoriasis as it does in generalized body psoriasis," Dr. James Krell from Total Skin and Beauty Dermatology Center, Birmingham, Alabama told Reuters Health.
阿拉巴马伯明翰全皮肤和美容皮肤病学中心的James Krell 博士告诉路透社的健康记者Alecfacept对头皮银屑病的作用跟全身银屑病的作用是一样的。
Dr. Krell and colleagues evaluated the safety and efficacy of alefacept in treating scalp psoriasis in 30 adults, all of whom received 16 once-weekly 15-mg intramuscular doses followed by a 12-week rest period. Those who did not achieve clearing received a second course of treatment.
通过对30名成人的治疗，Krell博士及其同事对Alefacept的安全性和有效性进行了评估。这些人都接受肌注一周一次，每次15mg，连续使用16周，然后停药12周的治疗。如果没有疗效，继续使用一个疗程。
Five patients (16.7%) achieved treatment success at week 6 after the first course of treatment, the authors report, and an additional 5 patients achieved treatment success 6 weeks after the second course of treatment.
5名病人（16.7％）在第一个疗程的第六周就取得疗效，另有5名病人在第二个疗程的第六周也取得疗效。
A total of 16 patients (8 after each course of treatment) experienced at least a 75% reduction in their scalp psoriasis area and severity index, the researchers note, and 14 patients (7 after each course of treatment) rated themselves as much improved after treatment.
总共16名病人（每个疗程后有8名）头皮银屑病的面积严重指数至少缩减了75％。14名病人（每个疗程后有7名）在治疗后称自己（的情况）有所好转。
Only 1 patient reported treatment-related adverse events, including nausea, malaise, and gastrointestinal upset, and no patients withdrew from the study or missed doses because of low CD4+ T lymphocyte counts.
只有1名病人产生了副作用，包括恶心、不适、胃肠不适。没有病人因为低CD4+ T细胞计数而退出此研究或者错过服药。
"It is always worth keeping alefacept in mind for the right patient when a very safe biologic medication is needed," Dr. Krell concluded. "As in other forms of psoriasis, alefacept is a third-line drug for me. As far as biologics go, I tend to use either an anti-TNF or Raptiva (efalizumab) before alefacept."
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作者:admin@医学,生命科学 2010-10-01 17:11
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