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【medical-news】多极射频消融治疗肝转移癌有效
Use of multipolar radiofrequency ablation in the treatment of colorectal liver metastases is effective and has a relatively low recurrence rate, according to a recent study conducted by researchers at Charité, Campus Benjamin Franklin in Berlin, Germany.
“Radiofrequency ablation (RFA) has become a widely used treatment option for patients with primary liver cancer and liver metastases from some primary tumors, if surgery is not an option. However, because of limited sizes of the ablation zones the technique has been limited to tumors smaller than four centimeters,” said Bernd Frericks, MD, lead author of the study. “This long-term study (four years) was performed using a new multipolar radiofrequency (RF)-device allowing for up to six ablation probes to be used simultaneously, thus providing larger ablation zones. We evaluated this new technique prospectively regarding ablation zone size, technical effectiveness, complications and clinical outcome in patients with colorectal liver metastases,” he said.
The study evaluated 27 patients with 67 colorectal liver metastases that were treated using multipolar RF ablation. According to the study, complete tumor destruction occurred in 66 of 67 cases. Of the 67 metastases, eight required reablation. After a mean of nine months, 16 patients developed new metastases in the liver and the lung, eight of which were successfully reablated. After four years, 52% of the patients are now tumor-free and 78% are still living.
“Using this new device, the rate of local tumor progressions was not influenced by the size of the tumor to be treated,” said Dr. Frericks.
http://www.eurekalert.org/pub_releases/2008-04/arrs-nti041108.php 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 一项治疗肝癌的新技术被认为是有效的
来自德国柏林本杰明富兰克林学院Charité所研究者最新研究报道中称，一项称之为多极射频消蚀技术在应用于结直肠癌并有肝脏转移的患者被认为是有效的，并且复发率较低。
在报道中，这项研究的学术领导，伯恩•弗莱利克斯博士称：“目前射频消蚀技术（RFA）已经被广泛应用于那些不适合手术的原发性肝癌以及原发性肿瘤肝脏转移患者。然而由于RFA消蚀切除肿瘤的范围有限，所以目前仅应用于肿瘤直径小于4CM的患者。而在我们的一项已经进行了四年的研究发现应用新的包括六枚消蚀探针的多级射频装置可以大大提高RFA切除肿瘤的范围。我们目前正在评价这项新技术的应用前景，包括射频消蚀范围、新技术的有效性与复杂性以及临床应用成果。”
该研究目前已经评估了应用多极射频消蚀技术进行治疗的27名肿瘤患者，这27名肿瘤患者些共患有67种结直肠癌伴有肝脏转移。研究结果发现，多极射频消蚀技术成功完整破坏了其中66处原发肿瘤病灶。而在67处转移病灶中，有8处转移病灶需要再次应用多极射频消蚀技术。经过9个月的周期之后，27名患者中有16名患者在肝脏和肺脏出现了新的转移病灶，其中8名患者成功接受了再次多极射频消蚀术。而在回访4年周期后，27名患者的存活率高达78%，而其中有52%的患者目前没有感染任何肿瘤。
弗莱利克斯博士还提到：“应用新的多级射频装置之后，患者局部肿瘤发生率并不受到接受多极射频消蚀术治疗的原发病灶大小的影响。”
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作者:admin@医学,生命科学 2010-11-24 05:11
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