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【medical-news】布洛芬阿司匹林等可以降低痴呆风
Using information from six different studies, researchers examined data on NSAID use in 13,499 people without dementia. Over the course of these six studies, 820 participants developed Alzheimer's disease.
Researchers found that people who used NSAIDs had 23 percent lower risk of developing Alzheimer's disease compared to those who never used NSAIDs. The risk reduction did not appear to depend upon the type of NSAID taken.
"This is an interesting finding because it seems to challenge a current theory that the NSAID group which includes ibuprofen may work better in reducing a person's risk of Alzheimer's," said study author Peter P. Zandi, PhD, with Johns Hopkins Bloomberg School of Public Health in Baltimore, MD. "The NSAID group that includes ibuprofen was thought to target a certain type of plaque in the brain found in Alzheimer's patients. But our results suggest there may be other reasons why these drugs may reduce the risk of Alzheimer's."
The study's lead author Chris Szekely, PhD, with Cedars Sinai Medical Center in Los Angeles, says the discrepancy between studies such as this one and the negative clinical trials of NSAIDs in treatment or prevention of Alzheimer's need to be further explored.
Data used in the study were collected with support from the National Institutes of Health and the Canadian Institutes of Health Research.
http://www.mphtimes.com/bbs/viewthread.php?tid=744&extra=page%3D1&frombbs=1 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Different types of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, and aspirin, appear to be equally effective in lowering the risk of Alzheimer's disease, according to the largest study of its kind published in the May 28, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. Experts have debated whether a certain group of NSAIDs that includes ibuprofen may be more beneficial than another group that includes naproxen and aspirin.不同种类的非甾体抗炎药（NSAIDs），如布洛芬、萘普生、以及阿司匹林，在降低阿尔兹海默病的危险方面似乎显示了同样的效果，该结论来源于美国神经病学学会的网上杂志于2008年5月28日发表的大样本临床研究。专家们讨论了是否非甾体抗炎药中包括布洛芬在内的组别显示了比萘普生和阿司匹林所属组别更好的效果。
Using information from six different studies, researchers examined data on NSAID use in 13,499 people without dementia. Over the course of these six studies, 820 participants developed Alzheimer's disease.
利用六项不同研究提供的信息，研究者对13499名无痴呆病史者的NSAID使用数据进行调查。在这六项研究全过程中，820名参与者发展成阿尔兹海默病。
Researchers found that people who used NSAIDs had 23 percent lower risk of developing Alzheimer's disease compared to those who never used NSAIDs. The risk reduction did not appear to depend upon the type of NSAID taken.
研究者发现，与那些从未使用NSAIDs的人相比，服用NSAIDs者患阿尔兹海默病的危险降低了23%。该危险性的降低似乎与所用NSAIDs种类相关性不大。
"This is an interesting finding because it seems to challenge a current theory that the NSAID group which includes ibuprofen may work better in reducing a person's risk of Alzheimer's," said study author Peter P. Zandi, PhD, with Johns Hopkins Bloomberg School of Public Health in Baltimore, MD. "The NSAID group that includes ibuprofen was thought to target a certain type of plaque in the brain found in Alzheimer's patients. But our results suggest there may be other reasons why these drugs may reduce the risk of Alzheimer's."
“这是个很有意思的发现，因为看来它对目前认为布洛芬类NSAIDs在降低阿尔兹海默病发病危险性优于其它NSAIDs的主流观念提出了挑战。”本文作者，Peter P. Zandi说，他是马里兰州约翰霍普金斯彭博公共卫生学院的公共卫生博士，“布洛芬类NSAIDs被认为能靶向作用于阿尔兹海默病患者脑中的某种斑块，但我们的研究提示在该类药物降低阿尔兹海默病危险性方面也许存在其它的机制。”
The study's lead author Chris Szekely, PhD, with Cedars Sinai Medical Center in Los Angeles, says the discrepancy between studies such as this one and the negative clinical trials of NSAIDs in treatment or prevention of Alzheimer's need to be further explored.
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作者:admin@医学,生命科学 2010-10-01 17:11
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