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【文摘发布】动脉瘤性蛛网膜下腔出血后脑梗死
hemorrhage.
Author： Fergusen S, Macdonald RL.
Resource: Neurosurgery. 2007 Apr;60(4):658-67; discussion 667.
Abstract：OBJECTIVE: Cerebral infarction would be expected to be associated with poor outcome after aneurysmal subarachnoid hemorrhage (SAH), although there are few data on which to base this assumption. The goals of this study were to determine
the impact of cerebral infarction on outcome and to examine predictors of
infarction in these patients. METHODS: Univariate and multivariable statistical
methods were used to examine the impact of cerebral infarction on the Glasgow
Outcome Scale score 3 months after SAH among 3567 patients entered into four
prospective, randomized, double-blind, placebo-controlled trials of tirilazad
conducted in neurosurgical centers around the world between 1991 and 1997.
Patient demographics, clinical variables, radiographic characteristics, and
treatment variables associated with cerebral infarction were also determined by
the same methods. RESULTS: Seven hundred and seven (26%) out of 2741 patients
with complete data had cerebral infarction on computed tomographic scans 6 weeks
after SAH. Multivariable logistic regression showed that cerebral infarction
increased the odds of unfavorable outcome by a factor of 5.4 (adjusted odds
ratio, 5.4; 95% confidence interval, 4.2-6.8; P < 0.0001), which was a higher
odds ratio than all other factors associated with outcome. The proportion of
explained variance in outcome was also highest for cerebral infarction and
accounted for 39% of the explained variance. Multivariable analysis found that
cerebral infarction was significantly associated with increasing patient age,
worse neurological grade on admission, history of hypertension or diabetes
mellitus, larger aneurysm, use of prophylactically or therapeutically induced
hypertension, temperature more than 38 degrees C 8 days after SAH, and
symptomatic vasospasm. CONCLUSION: Cerebral infarction was strongly associated
with poor outcome after aneurysmal SAH. The most important potentially treatable
factor associated with infarction was symptomatic vasospasm.
PMID: 17415202 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：Predictors of cerebral infarction in patients with aneurysmal subarachnoid
hemorrhage.
题目：动脉瘤性蛛网膜下腔出血后脑梗死的预测因子
Author： Fergusen S, Macdonald RL.
作者：Fergusen S, Macdonald RL.
Resource: Neurosurgery. 2007 Apr;60(4):658-67; discussion 667.
来源：《神经外科学》. 2007 Apr;60(4):658-67; discussion 667.
Abstract：摘要：
OBJECTIVE: Cerebral infarction would be expected to be associated with poor outcome after aneurysmal subarachnoid hemorrhage (SAH), although there are few data on which to base this assumption.
目的：动脉瘤性蛛网膜下腔出血(SAH)后的脑梗提示预后不良，尽管尚无足够多的资料支持这一假想。
The goals of this study were to determine the impact of cerebral infarction on outcome and to examine predictors of infarction in these patients.
本研究的目的是为了确定脑梗对此类病人预后的影响及检验脑梗的预测因子。
METHODS: Univariate and multivariable statistical methods were used to examine the impact of cerebral infarction on the Glasgow Outcome Scale score 3 months after SAH among 3567 patients entered into four prospective, randomized, double-blind, placebo-controlled trials of tirilazad conducted in neurosurgical centers around the world between 1991 and 1997.
方法：本实验所用病例来自于参加1991至1997年在世界各地神经外科中心进行的四项前瞻性、随机、双盲、对照替拉扎特实验的3567名病人。采用单因素和多因素统计方法检验动脉瘤性蛛网膜下腔出血（SAH） 3个月后脑梗对格拉斯哥预后评分的影响。
Patient demographics, clinical variables, radiographic characteristics, and treatment variables associated with cerebral infarction were also determined by the same methods.
用同样的方法处理病人的人口统计学数据、临床数据、放射学特征和治疗数据这些与脑梗相关的变量
RESULTS: Seven hundred and seven (26%) out of 2741 patients with complete data had cerebral infarction on computed tomographic scans 6 weeks after SAH.
结果：有完整资料的2741名病人中的707名（26%）发生SAH后六周在CT扫描上表现为脑梗。
Multivariable logistic regression showed that cerebral infarction increased the odds of unfavorable outcome by a factor of 5.4 (adjusted odds ratio, 5.4; 95% confidence interval, 4.2-6.8; P < 0.0001), which was a higher odds ratio than all other factors associated with outcome.
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作者:admin@医学,生命科学 2011-05-02 05:11
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