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【bio-news】在原免疫细胞中人睾丸也具有HIV－1病
Human testis harbors HIV-1 in resident immune cells
Rennes, France -- Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy. The related report by Roulet et al., 揝usceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro,?appears in the December issue of The American Journal of Pathology.
According to the most recent World Health Organization data, 39.5 million people are infected with HIV. Semen remains the main means of spreading the virus, even though highly active antiretroviral therapy (HAART) can successfully suppress virus in the blood. The presence of HIV in the semen despite successful HAART has intrigued scientists.
Researchers led by Dr. Nathalie Dejucq-Rainsford examined testis tissue for the presence of HIV receptors. They found that all of the necessary cellular receptors (CD4, CXCR4, CCR5, and DC-SIGN) were present on cells located within the testis, specifically testicular macrophages.
The point was demonstrated further by using explanted organ cultures in which human testis tissue was grown in culture. This testis culture, which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture.
The finding that HIV-1 can replicate within testicular macrophages is significant because the testis represents a pharmacological sanctuary梞any anti-retroviral drugs have difficulty penetrating this organ and may be present at sub-therapeutic levels. Thus, although HAART may achieve undetectable virus levels in the blood, virus replication in the testis may permit continued spread of the virus.
Finally, with HIV infection continuing to rise, the development of anti-retroviral therapy that effectively targets all sources of HIV, including the testis, is gravely needed. The use of this testis culture system may allow assessment of new anti-retroviral drugs that target HIV in the testis.
### 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 【bio-news】在原免疫细胞中人睾丸也具有HIV－1病毒
Human testis harbors HIV-1 in resident immune cells
人睾丸固有免疫细胞中隐匿着HIV－1病毒
Rennes, France -- Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy. The related report by Roulet et al., 揝usceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro,?appears in the December issue of The American Journal of Pathology.
消息来自法国的Rennes—研究者证实HIV在人睾丸固有免疫细胞中复制，而且即使给予高强度有效的抗病毒治疗后病毒仍然在精液中持续存活。Roulet et al.在美国病理学杂志12月期进行了相关报道：人睾丸内外HIV……
According to the most recent World Health Organization data, 39.5 million people are infected with HIV. Semen remains the main means of spreading the virus, even though highly active antiretroviral therapy (HAART) can successfully suppress virus in the blood. The presence of HIV in the semen despite successful HAART has intrigued scientists.
按照新近世界卫生组织的数据，3千9百万人感染了HIV。即使高强度的抗病毒治疗可以成功杀灭血液中的病毒，精液仍然可以成为病毒传播的主要途径。高强度的抗病毒治疗后HIV在精液中的存在引起了科学家的注意。
Researchers led by Dr. Nathalie Dejucq-Rainsford examined testis tissue for the presence of HIV receptors. They found that all of the necessary cellular receptors (CD4, CXCR4, CCR5, and DC-SIGN) were present on cells located within the testis, specifically testicular macrophages.
在Nathalie Dejucq-Rainsford博士的带领下研究者们检测了HIV受体的存在情况。他们发现所有的必需细胞受体(CD4, CXCR4, CCR5, DC-SIGN)都在睾丸组织内细胞上存在，特别是睾丸巨噬细胞。
The point was demonstrated further by using explanted organ cultures in which human testis tissue was grown in culture. This testis culture, which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture.
理论得到了进一步证明。研究者应用分离器官培养人睾丸组织，这些睾丸组织培养物和体内组织结构一样、也能分泌睾酮，并且可以受到HIV-1的感染。在睾丸组织培养物中产生的病毒有很高的活性，就像采集的病毒一样，可以感染培养的允许细胞。
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作者:admin@医学,生命科学 2011-04-30 17:11
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