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【Cancer research】鞣花酸抗胰腺癌的作用机制
Ellagic acid was previousely shown to have anticarcinogenic, antioxidant and antifibrosis properties. The anticarcinogenic effect of ellagic acid was shown in several types of cancers including skin, esophageal, and colon cancers. However the mechanisms mediating anti-cancer effect of ellagic acid, in general, remain unknown.
A research article published on 21 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Edderkaoui from West Los Angeles VA Healthcare Center showed that Ellagic acid increases programmed cell death and decreases proliferation of pancreatic cancer cells. They showed that the mechanism through which ellagic acid causes cell death is through decreasing the activity of the pro-survival transcription factor NF-kB. The compound does not affect mitochondria. The results presented in this article show for the first time how this polyphenol regulates cancer cell proliferation and resistance to death and may help surpass the resistance of these cells to radio and chemotherapies.
The data in this article demonstrate the anti-cancer properties of ellagic acid as well as its mechanism of action. This opens the possibilities of using this compound in combination with other drugs that target other pro-survival proteins to increase cell death in pancreatic cancer cells. 本人已认领此文，若48小时未提交，请其它战友领取。 编译字数：375
鞣花酸是怎样发挥抗胰腺癌作用的？
此前的研究表明鞣花酸具有抗肿瘤、抗氧化和抗纤维化的作用。鞣花酸的抗肿瘤作用在包括皮肤癌、食道癌和结肠癌的几种癌症中都得到了证实。可是其抗癌的普遍机制还不为人所知。
刊登在2008年六月21日出版的世界胃肠病杂志上的一篇研究性文章就这一问题进行了研究。由西洛杉矶VA卫生中心的Edderkaoui博士领导的研究小组揭示出鞣花酸可使胰腺癌细胞程序化死亡加剧，同时减少其增殖。鞣花酸是通过减少促存活的转录因子NF-kB的活性而加剧细胞死亡的。鞣花酸本身不影响线粒体。文章的这些结论首次揭示了这一多酚化合物是怎样调节癌细胞的增殖和对死亡的抵抗，这可能对克服癌细胞对放疗化疗的抵抗有所帮助。
稳重的数据揭示了鞣花酸的抗癌性质及作用机制。这是我们可能使用这一化合物联合其他药物共同作用于其他的促存活蛋白来增加胰腺癌细胞的死亡。 某些部分似乎有些不妥
The anticarcinogenic effect of ellagic acid was shown in several types of cancers including skin, esophageal, and colon cancers. However the mechanisms mediating anti-cancer effect of ellagic acid, in general, remain unknown.
“鞣花酸的抗肿瘤作用在包括皮肤癌、食道癌和结肠癌的几种癌症中都得到了证实。可是其抗癌的普遍机制还不为人所知。”
鞣花酸对皮肤癌、食道癌和结肠癌等数种肿瘤具有抗肿瘤作用，但总体而言，其抗癌作用的机制还不甚明了。
“稳重的数据揭示了鞣花酸的抗癌性质及作用机制。这是我们可能使用这一化合物联合其他药物共同作用于其他的促存活蛋白来增加胰腺癌细胞的死亡。 "
本研究不仅证实了鞣花酸的抗癌作用，还发现了其作用机制。这使得人们可能在使用这一化合物的同时联合使用作用于另一促存活蛋白的药物，以促进胰腺癌细胞的死亡。
纯属交流，请指正。 我曾经在做植化分离时得到过较大量的鞣花酸,这个发现是否意味说那味药会有较好的研发前景呢? [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-14 17:11
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