主页 > 医学新闻 >
【drug-news】儿童非酒精性脂肪肝的新疗法
New Treatment Tested for Fatty Liver Disease in Children
INDIANAPOLIS, IN -- March 16, 2007 -- Researchers are taking a closer look at a disease whose incidence is rising as obesity in children increases. Non-Alcoholic Steatohepatitis, more popularly known as Fatty Liver Disease, occurs in approximately 15% of obese children.
Fatty Liver Disease, in which fat accumulates in the liver, while not life threatening in children, can lead to cirrhosis, sometimes requiring transplantation by adulthood.
"Until now the only treatment for Fatty Liver Disease has been to offer diet and exercise counseling, but this is often not effective. As part of a national multicenter research network, we are now looking at Vitamin E and at metformin, a drug used to treat Type II diabetes, as possible therapies" said Jean Molleston, MD, clinical professor of pediatrics at Indiana University School of Medicine and director of pediatric gastroenterology at Riley Hospital for Children.
Molleston is the pediatric principal investigator for the IU School of Medicine site of TONIC, an eight-center Phase III study funded by the National Institute of Diabetes and Digestive and Kidney Disease, which is investigating treatment options for Fatty Liver Disease in 8 to 17 year olds and is the largest study of its type to date.
"We are seeing a growing number of young people with Fatty Liver Disease, and we need to tackle the disease before it becomes full blown in adulthood," said Molleston. "We routinely test children for conditions with much lower incidence such as scoliosis. Although we do not yet have formal guidelines for screening for Fatty Liver Disease, I personally think that all obese children should be screened for Fatty Liver Disease so we can intervene before it damages the liver."
A simple blood test to determine if liver enzyme levels are elevated alerts pediatricians that the child needs to be evaluated for Fatty Liver Disease. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 New Treatment Tested for Fatty Liver Disease in Children
儿童非酒精性脂肪肝的新疗法
INDIANAPOLIS, IN -- March 16, 2007 -- Researchers are taking a closer look at a disease whose incidence is rising as obesity in children increases. Non-Alcoholic Steatohepatitis, more popularly known as Fatty Liver Disease, occurs in approximately 15% of obese children.
随着肥胖儿童的增加，研究人员更密切的关注与之相关的一种疾病。非酒精性脂肪性肝炎（更为人之的名称是脂肪肝）在大约15％的肥胖儿童中发生。
Fatty Liver Disease, in which fat accumulates in the liver, while not life threatening in children, can lead to cirrhosis, sometimes requiring transplantation by adulthood.
脂肪肝病时肝脏脂肪积累，虽然这在儿童时期并没有生命威胁，但是到成年时期，可导致肝硬化，有时甚至需要接受肝移植。
"Until now the only treatment for Fatty Liver Disease has been to offer diet and exercise counseling, but this is often not effective. As part of a national multicenter research network, we are now looking at Vitamin E and at metformin, a drug used to treat Type II diabetes, as possible therapies" said Jean Molleston, MD, clinical professor of pediatrics at Indiana University School of Medicine and director of pediatric gastroenterology at Riley Hospital for Children.
印第安纳州大学医学院儿科学临床教授、Riley儿童医院小儿胃肠病科主任Jean Molleston医学博士说：“至今为止，脂肪肝的唯一治疗方法就是控制饮食和适当运动，但是这常常不太有效。作为国家多中心研究网络的一部分，我们正在尝试用维生素E和二甲双胍（一种治疗II型糖尿病的药物）作为可能的治疗方法。”
Molleston is the pediatric principal investigator for the IU School of Medicine site of TONIC, an eight-center Phase III study funded by the National Institute of Diabetes and Digestive and Kidney Disease, which is investigating treatment options for Fatty Liver Disease in 8 to 17 year olds and is the largest study of its type to date.
Molleston是TONIC八中心III期试验印第安纳州大学医学院网点的首席研究员，这项试验由国立糖尿病、消化疾病与肾病研究院资助，目的是研究治疗8-17岁脂肪肝患者的治疗方案，同时，这是同类型研究中至今为止最大的一项研究。
"We are seeing a growing number of young people with Fatty Liver Disease, and we need to tackle the disease before it becomes full blown in adulthood," said Molleston. "We routinely test children for conditions with much lower incidence such as scoliosis. Although we do not yet have formal guidelines for screening for Fatty Liver Disease, I personally think that all obese children should be screened for Fatty Liver Disease so we can intervene before it damages the liver."
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-24 21:18
医学,生命科学网