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【medical-news】家庭机械通气改善脊柱后侧凸患者
NEW YORK (Reuters Health) Jan 02 - Survival of patients with nonparalytic kyphoscoliosis is better with home mechanical ventilation than with long-term oxygen therapy alone, investigators in Sweden report.
Home mechanical ventilation and long-term oxygen therapy are commonly used to treat respiratory insufficiency in patients with kyphoscoliosis, the authors explain, but it is unclear which yields better outcomes.
Dr. Torbjorn Gustafson, from Skelleftea Hospital, and colleagues compared survival in 100 patients who were treated with home mechanical ventilation with survival in 144 patients treated with long-term oxygen therapy alone. The findings are published in the December 2006 issue of Chest.
At follow-up, 32% of patients receiving home mechanical ventilation were dead, compared with 76% of patients receiving long-term oxygen therapy, the authors report.
The survival advantage of home mechanical ventilation persisted after adjustment for age, gender, concomitant respiratory diseases, and blood gas levels, the results indicate.
Other factors associated with worse survival were being older than 70 years, the presence of a concomitant respiratory disease, low PaO2, and low PaCO2, the researchers note.
"The results of our study indicate that the vast majority of patients with kyphoscoliosis who are treated with oxygen therapy alone lose several years of potential survival due to ineffective therapy," the investigators write.
"We suggest home mechanical ventilation and not oxygen therapy alone as the primary therapy for patients with respiratory failure due to kyphoscoliosis, regardless of gender, age, and the presence of concomitant respiratory diseases," the authors conclude.
Chest 2006;130:1828-1833.
http://www.medscape.com/viewarticle/550176 Home Mechanical Ventilation Improves Survival of Kyphoscoliosis Patients
家庭机械通气改善脊柱后凸患者存活率
NEW YORK (Reuters Health) Jan 02 - Survival of patients with nonparalytic kyphoscoliosis is better with home mechanical ventilation than with long-term oxygen therapy alone, investigators in Sweden report.
纽约路透社健康专栏1月2日——瑞典的研究人员报道，用家庭机械通气的非瘫痪的脊柱后凸患者存活率优于单用长期氧疗者。
Home mechanical ventilation and long-term oxygen therapy are commonly used to treat respiratory insufficiency in patients with kyphoscoliosis, the authors explain, but it is unclear which yields better outcomes.
作者解释道，家庭机械通气和长期氧疗常用于治疗脊柱后凸患者的呼吸功能不全，但哪种方法效果较好目前仍不清楚。
Dr. Torbjorn Gustafson, from Skelleftea Hospital, and colleagues compared survival in 100 patients who were treated with home mechanical ventilation with survival in 144 patients treated with long-term oxygen therapy alone. The findings are published in the December 2006 issue of Chest.
谢莱夫特奥医院的Torbjorn Gustafson医生和其同事比较100例家庭机械通气治疗的患者和144例单用长期氧疗的患者的生存率。结果发表在2006年12月的Chest杂志上。
At follow-up, 32% of patients receiving home mechanical ventilation were dead, compared with 76% of patients receiving long-term oxygen therapy, the authors report.
在随访过程中，32%的家庭机械通气治疗病人死亡。与之相比，76%的单用长期氧疗的患者死亡。
The survival advantage of home mechanical ventilation persisted after adjustment for age, gender, concomitant respiratory diseases, and blood gas levels, the results indicate.
结果表明，家庭机械通气治疗的生存优势在经年龄、性别、并发的呼吸系统疾病、血气水平校正后仍存在。
Other factors associated with worse survival were being older than 70 years, the presence of a concomitant respiratory disease, low PaO2, and low PaCO2, the researchers note.
研究者指出，和更差的生存率相关的是年龄大于70岁、存在并发的呼吸系统疾病、动脉血氧分压降低、动脉血二氧化碳分压降低。
"The results of our study indicate that the vast majority of patients with kyphoscoliosis who are treated with oxygen therapy alone lose several years of potential survival due to ineffective therapy," the investigators write.
研究者写道：“我们的研究表明单用长期氧疗的大量的脊柱后凸患者由于无效的治疗而失去数年生存率。 ”
"We suggest home mechanical ventilation and not oxygen therapy alone as the primary therapy for patients with respiratory failure due to kyphoscoliosis, regardless of gender, age, and the presence of concomitant respiratory diseases," the authors conclude.
作者的结论是：“我们建议家庭机械通气治疗及不单用氧疗是对脊柱后凸引起的呼吸衰竭患者的主要治疗方法。
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作者:admin@医学,生命科学 2011-03-13 17:11
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