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【drug-news】Taking Viagra will worsen sleep apnea

Taking Viagra will worsen sleep apnea
服用伟哥家中睡眠呼吸暂停
According to Brazilian researchers, taking Viagra (sildenafil) at bedtime may aggravate breathing problems in patients with severe obstructive sleep apnea.
根据巴西研究者的研究,睡前服用伟哥可能会加重患有严重阻塞性睡眠呼吸暂停病人的呼吸问题。
Obstructive sleep apnea is a common problem that occurs when the soft tissues at the back of the throat collapse and close off the airway during sleep, resulting in brief moments in which breathing stops.
阻塞性睡眠呼吸暂停是一常见的问题。它经常发生在咽喉背面塌陷或睡眠时气道关闭,主要导致睡眠停止。
The researchers say that impotence, also known as erectile dysfunction, is far more common in patients with obstructive sleep apnea, but Viagra used to correct the condition also affects the sleep apnea by prolonging the action of nitric oxide, which promotes upper airway congestion.
研究者说阳痿即勃起功能障碍常合并阻塞性睡眠呼吸暂停。但是用来改善该状况的伟哥常会通过延长NO作用时间,加重上呼吸道阻塞从而影响到睡眠呼吸暂停。
Dr. Suely Roizenblatt, of Federal University of Sao Paulo, Brazil, and colleagues examined the effects of a single 50-mg dose of sildenafil on the sleep of 14 middle-aged men with severe obstructive sleep apnea.
巴西圣保罗联合大学的Suely Roizenblatt博士,以及其同事对14名患有严重阻塞性睡眠呼吸暂停的中年男性使用单次剂量50mg昔多芬,观察其可能产生的作用。
The men were randomly assigned to receive sildenafil or a placebo before they participated in an all-night sleep study, which included at least 7 hours of recording time. The next night the men switched treatments and process was repeated.
这些男性在参与整夜睡眠研究之前被随机分组接受昔多芬或安慰剂。该项研究包括至少七个小时的记录。接下来这些受试者改变疗法重复进行 该测试。
The research team say compared with the placebo, sildenafil led to a significantly increased number of episodes of oxygen reduction per hour of recording time (30.3 events per hour versus 18.5 events per hour).
通过对照安慰剂组,研究小组提出昔多芬在测试时间内显著增加缺氧发生几率(30.3/h对18.5/h)
They say there was also a significant increase in the percentage of total sleep time with an oxygen saturation of less than 90 percent (15.6 percent versus 7.9 percent) and a significant increase in the maximal duration of a desaturation event (72.5 seconds versus 48.1 seconds).
他们宣称氧饱和度低于90%的发生率在整个睡眠时间中也明显增加(15.6%对7.9%),而且去氧的最大周期明显延长(72.5秒对48.1秒)。
Dr. Roizenblatt's team says sleep structure was also altered by sildenafil use, with in increase in stage 2 non-rapid eye movement sleep compared with placebo and a decrease in deep sleep compared with the start of the study and placebo.
Roizenblatt博士小组提到昔多芬的使用同时会改变睡眠结构。对照安慰剂组延长了二期非快速动眼睡眠时间,而缩短了深睡眠的时间。
The researchers advise that in patients with severe obstructive sleep apnea, a single 50-mg dose of sildenafil at bedtime worsens respiratory and desaturation events.
研究者提示患有严重阻塞性睡眠呼吸暂停的病人睡前单剂50mg昔多芬会增加呼吸和去饱和事件的发生。 此消息本版已有报道
http://www.dxy.cn/bbs/post/view?bid=116&id=7189190&tpg=1&ppg=1&sty=1&age=30#7189190
另外,您的标题很难理解。

“服用伟哥家中睡眠呼吸暂”,是什么意思? 不好意思,打错字后把文中的这个词统一改正(应为“加重”)后,忘记改标题了。 [标签:content1][标签:content2]

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作者:admin@医学,生命科学    2011-03-04 01:28
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