主页 > 医学讨论 >
【medical-news】小事件引发大灾难——染色体与癌
Cancer in a Single Catastrophe: Chromosome Crisis Common in Cancer Causation
ScienceDaily (Jan. 10, 2011) — Remarkable new research overthrows the conventional view that cancer always develops in a steady, stepwise progression. It shows that in some cancers, the genome can be shattered into hundreds of fragments in a single cellular catastrophe, wreaking mutation on a massive scale.
The scars of this chromosomal crisis are seen in cases from across all the common cancer types, accounting for at least one in forty of all cancers. The phenomenon is particularly common in bone cancers, where the distinctively ravaged genome is seen in up to one in four cases.
The team looked at structural changes in the genomes of cancer samples using advanced DNA sequencing technologies. In some cases, they found dramatic structural changes affecting highly localised regions of one or a handful of chromosomes that could not be explained using standard models of DNA damage.
"The results astounded us," says Dr Peter Campbell, from the Cancer Genome Project at the Wellcome Trust Sanger Institute and senior author on the paper. "It seems that in a single cell in a single event, one or more chromosomes basically explode -- literally into hundreds of fragments.
"In some instances -- the cancer cases -- our DNA repair machinery tries to stick the chromosomes back together but gets it disastrously wrong. Out of the hundreds of mutations that result, several promote the development of cancer."
Cancer is typically viewed as a gradual evolution, taking years to accumulate the multiple mutations required to drive the cancer's aggressive growth. Many cancers go through phases of abnormal tissue growth before eventually developing into malignant tumours.
The new results add an important new insight, a new process that must be included in our consideration of cancer genome biology. In some cancers, a chromosomal crisis can generate multiple cancer-causing mutations in a single event.
"We suspect catastrophes such as this might happen occasionally in the cells of our body," says Dr Andy Futreal, Head of Cancer Genetics and Genomics at the Wellcome Trust Sanger Institute and an author on the paper. "The cells have to make a decision -- to repair or to give up the ghost.
"Most often, the cell gives up, but sometimes the repair machinery sticks bits of genome back together as best it can. This produces a fractured genome riddled with mutations which may well have taken a considerable leap along the road to cancer."
The new genome explosions caused 239 rearrangements on a single chromosome in one case of colorectal cancer.
The damage was particularly common in bone cancers, where it affected five of twenty samples. In one of these samples the team found three cancer genes that they believe were mutated in a single event: all three are genes that normally suppress cancer development and when deleted or mutated can lead to increased cancer development.
"The evidence suggests that a single cellular crisis shatters a chromosome or chromosomes," says Professor Mike Stratton, Director of the Wellcome Trust Sanger Institute and an author on the paper, "and that the DNA repair machinery pastes them back together in a highly erroneous order.
"It is remarkable that, not only can a cell survive this crisis, it can emerge with a genomic landscape that confers a selective advantage on the clone, promoting evolution towards cancer."
The team propose two possible causes of the damage they see. First, they suggest it might occur during cell division, when chromosomes are packed into a condensed form. Ionizing radiation can cause breaks like those seen. The second proposition is that attrition of telomeres -- the specialized genome sequences at the tips of chromosomes -- causes genome instability at cell division.
This work was supported by the Wellcome Trust and the Chordoma Foundation.
Evidence of chromothripsis in small cell lung cancer. (Credit: Stephens PJ et al. (2011) Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell) [热点资讯]再论转基因水稻,越国计谋的现代版?_经济论坛_天涯社...(1)、与人类生命健康相关的重大科学实验,除了对小鼠的实验外,必须有人类作临床实验.... (Gillam,2006). 4)、美国转基因水稻污染事件:2006年8月,美国农业部的一则公告引发了...www.tianya.cn/.../396233.shtml-2010-03-25-快照-[标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-01-12 00:05
医学,生命科学网