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【medical-news】人种的激素水平差异会导致乳腺癌
Los Angeles, Oct. 10, 2006 ?Researchers have known that a woman's natural hormone levels can affect her risk of developing breast cancer. A new study from the University of Southern California (USC) has found that the natural levels of estrogens in post-menopausal women varies by ethnicity and race, and may explain the differences in the groups' breast cancer rates. The study appears in the October issue of Cancer Epidemiology, Biomarkers & Prevention.
Using data from the Multiethnic Cohort Study, V. Wendy Setiawan, Ph.D., assistant professor of preventive medicine at the Keck School of Medicine of USC, and her colleagues determined that of the five primary ethnicities/races in the cohort, native Hawaiians have the highest risk of breast cancer--65 percent greater than whites. They also had some of the highest levels of circulating estrogens.
"We had observed that some groups, such as native Hawaiians have higher breast cancer rates compared to white women. We knew hormones are a factor, so we decided to test them," says Setiawan. "The research seems to support that idea."
The researchers also found that Japanese-American women have comparatively high estrogen levels and the second highest breast cancer risk of the five groups. "This is interesting because breast cancer rates have been increasing steadily in Japanese women who live in the United States, as well as in women who live in Japan," Setiawan says. "We think it could be caused by lifestyle changes that impact age at first menstruation or other factors."
Latinas had similar hormone profiles to whites, while women who had recently immigrated had slightly lower levels, but which were not statistically significant, the researchers found. However, Latinas' risk of breast cancer is the lowest of the groups studied.
One of the most interesting findings was that African-American women have a slightly lower post-menopausal breast cancer risk than whites, despite having comparatively higher post-menopausal hormone levels.
"It is known that before menopause, African-American women have a higher breast cancer risk than whites, as well as higher estrogen levels," Setiawan says. "It would be interesting to find out why their elevated rates do not persist after menopause, despite having comparatively higher estrogen levels."
The researchers analyzed the hormone levels in 739 postmenopausal women in the cohort who were not on hormone replacement therapy. After adjusting the hormone levels for age, body mass index, and other lifestyle factors, they then compared the levels to their ethnic/racial groups' breast cancer incidences. The study is the largest analysis of hormone levels by ethnic group, and the first large study of native Hawaiians and Latinas.
"Clearly, more work is needed to identify factors that contribute to racial and ethnic differences in hormone levels," Setiawan says.
### 认领了 人种的激素水平差异会导致乳腺癌发病风险的不同
Ethnic variations in hormone levels may cause differences in breast cancer risk
Los Angeles, Oct. 10, 2006 ?Researchers have known that a woman's natural hormone levels can affect her risk of developing breast cancer. A new study from the University of Southern California (USC) has found that the natural levels of estrogens in post-menopausal women varies by ethnicity and race, and may explain the differences in the groups' breast cancer rates. The study appears in the October issue of Cancer Epidemiology, Biomarkers & Prevention.
洛杉矶，2006年10月10日 研究者已经发现妇女的自然激素水平可能影响患乳腺癌的风险。南加州大学一项新研究发现：绝经后妇女的自然雌激素水平具有种族差异，这可能解释乳腺癌在不同人群中发病率的差异。该研究结果发表在九月份的《癌症流行病学、生物标记物和预防杂志》（the October issue of Cancer Epidemiology, Biomarkers & Prevention）上。
Using data from the Multiethnic Cohort Study, V. Wendy Setiawan, Ph.D., assistant professor of preventive medicine at the Keck School of Medicine of USC, and her colleagues determined that of the five primary ethnicities/races in the cohort, native Hawaiians have the highest risk of breast cancer--65 percent greater than whites. They also had some of the highest levels of circulating estrogens.
南加州大学Keck医学院预防医学助教授V. Wendy Setiawan博士和他的同事们根据多人种队列研究资料发现：在队列研究的五个主要人种中，夏威夷土著人患乳腺癌的风险最高—比白种人高65%，其体内循环雌激素水平也最高。
"We had observed that some groups, such as native Hawaiians have higher breast cancer rates compared to white women. We knew hormones are a factor, so we decided to test them," says Setiawan. "The research seems to support that idea."
“我们已经观察了一些人群，诸如夏威夷土著人比白种人妇女乳腺癌患病率更高。我们认为激素是一种影响因素，并决定检测激素水平。”Setiawan说。“该实验似乎支持这一观点。”
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作者:admin@医学,生命科学 2010-12-29 17:14
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