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【medical-news】研究发现肥胖男性患前列腺癌的风
NEW YORK (Reuters Health) - Use of cholesterol-lowering statin drugs, especially long-term use, appears to raise the risk of prostate cancer among obese men, according to findings of a new study.
"Given the epidemic of obesity in the U.S. and the frequent use of statins, the positive association we observed raises substantial concern as to the safety of these widely prescribed agents," Dr. Janet L. Stanford of the Fred Hutchinson Cancer Research Center in Seattle and colleagues wrote in the American Journal of Epidemiology.
In a population-based, case-control study, the researchers matched 1,001 men with prostate cancer diagnosed between 2002 and 2005 with 942 age-matched cancer-free controls from King County, Washington.
No overall association was observed between the risk of prostate cancer and the current or past use of statin treatment. Duration of statin use was also not associated with prostate cancer risk.
"We also found no evidence that use of a statin was associated with risk of developing more aggressive subtypes of prostate caner," Stanford said in an interview with Reuters Health. "Overall we found no support for the current hypothesis that statin use may reduce risk of prostate cancer."
However, the results do suggest a significant increase in the risk of developing prostate cancer associated with current statin use and with longer durations of use among obese men (defined as a body mass index of 30 greater).
"Among obese men," Stanford told Reuters Health, "current use of a statin was associated with a 50 percent increase in risk of prostate cancer; and use for 5 or more years was associated with an 80 percent increase in risk of the disease; both of these risk estimates were statistically significant."
These findings warrant further investigation, she said.
http://www.reuters.com/article/healthNews/idUSPAT26581320080822 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Prostate cancer risk increased in obese men: study
研究发现肥胖男性患前列腺癌的危险增加
NEW YORK (Reuters Health) - Use of cholesterol-lowering statin drugs, especially long-term use, appears to raise the risk of prostate cancer among obese men, according to findings of a new study.
纽约（路透社健康版）-根据一项新的研究发现，使用降胆固醇抑制剂药物，尤其是长期使用者，会增加肥胖男性患前列腺癌的风险。
"Given the epidemic of obesity in the U.S. and the frequent use of statins, the positive association we observed raises substantial concern as to the safety of these widely prescribed agents," Dr. Janet L. Stanford of the Fred Hutchinson Cancer Research Center in Seattle and colleagues wrote in the American Journal of Epidemiology.
“根据美国肥胖的流行病学调查和经常使用他汀类药物，我们发现了这种正性的关系，而且引起了我们对这些广泛使用药物的安全性的思考。”来自于西雅图Fred Hutchinson 癌症研究中心的斯坦福博士及其同时对美国流行病学杂志说。
In a population-based, case-control study, the researchers matched 1,001 men with prostate cancer diagnosed between 2002 and 2005 with 942 age-matched cancer-free controls from King County, Washington.
在一项以人口为基础的，病例对照研究中，研究者们配对研究了2002年至2005年间华盛顿King区1001例患有前列腺癌和942例年龄相当的无前列腺癌病人。
No overall association was observed between the risk of prostate cancer and the current or past use of statin treatment. Duration of statin use was also not associated with prostate cancer risk.
结果显示前列腺癌危险性和目前或过去使用的他汀类药物没有总体相关性。而且他汀类药物使用时间的长短与前列腺癌的危险性也没有相关性。
"We also found no evidence that use of a statin was associated with risk of developing more aggressive subtypes of prostate caner," Stanford said in an interview with Reuters Health. "Overall we found no support for the current hypothesis that statin use may reduce risk of prostate cancer."
“我们也发现使用他汀类药物与前列腺癌发展成侵袭性亚型的危险性无关。”斯坦福告诉路透社记者：“总之我们的结果不支持目前的假说，即他汀类药物的使用可能降低前列腺癌的危险。”
However, the results do suggest a significant increase in the risk of developing prostate cancer associated with current statin use and with longer durations of use among obese men (defined as a body mass index of 30 greater).
然而，该项研究结果却提示目前或长期使用他汀类药物的肥胖男性中患前列腺癌的风险增加（体重指数应>30）。
"Among obese men," Stanford told Reuters Health, "current use of a statin was associated with a 50 percent increase in risk of prostate cancer; and use for 5 or more years was associated with an 80 percent increase in risk of the disease; both of these risk estimates were statistically significant."
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作者:admin@医学,生命科学 2011-01-10 05:14
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