主页 > 医学讨论 >
【文摘发布】公路隧道空气污染导致健康人支气
Author:B-M. Larsson
Abstract:
Keywords: Air pollution, airway inflammation, bronchoalveolar lavage, cell count, particles
Received: March 13, 2006
Accepted January 7, 2007
Traffic-related air pollution is associated with adverse respiratory effects. The aim of the present study was to investigate whether exposure to air pollution in a road tunnel causes airway inflammatory and blood coagulation responses.
A total of 16 healthy subjects underwent bronchoscopy with bronchial mucosal biopsies and bronchoalveolar lavage (BAL) on two occasions, in random order: once at 14 h after a 2-h exposure to air pollution in a busy road tunnel, and once after a control day with subjects exposed to urban air during normal activities. Peripheral blood was sampled prior to bronchoscopy.
The road tunnel exposures included particulate matter with a 50% cut-off aerodynamic diameter of 2.5 µm, particulate matter with a 50% cut-off aerodynamic diameter of 10 µm and nitrogen dioxide which had median concentrations of 64, 176 and 230 µg·m–3, respectively. Significantly higher numbers of BAL fluid total cell number, lymphocytes and alveolar macrophages were present after road tunnel exposure versus control. Significantly higher nuclear expression of the transcription factor component c-Jun was found in the bronchial epithelium after exposure. No upregulation of adhesion molecules or cellular infiltration was present and blood coagulation factors were unaffected.
In conclusion, exposure of healthy subjects to traffic-related air pollution resulted in a lower airway inflammatory response with cell migration, together with signs of an initiated signal transduction in the bronchial epithelium.
Eur Respir J 2007; 29:699-705
认领及参与讨论者方可pm我要全文 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title:Road tunnel air pollution induces bronchoalveolar inflammation in healthy subjects
题目：公路隧道空气污染导致健康人群支气管肺泡炎症。
Author:B-M. Larsson
作者：B-M. Larsson
Abstract:
摘要
Keywords: Air pollution, airway inflammation, bronchoalveolar lavage, cell count, particles
关键词：空气污染，气道炎症，支气管肺泡灌洗，细胞计数，颗粒
Received: March 13, 2006
Accepted January 7, 2007
Traffic-related air pollution is associated with adverse respiratory effects. The aim of the present study was to investigate whether exposure to air pollution in a road tunnel causes airway inflammatory and blood coagulation responses.
汽车引起的空气污染对呼吸道有害。本研究的目的是为了探究暴露于公路隧道污染空气是否会引起呼吸道炎症和凝血反应。
A total of 16 healthy subjects underwent bronchoscopy with bronchial mucosal biopsies and bronchoalveolar lavage (BAL) on two occasions, in random order: once at 14 h after a 2-h exposure to air pollution in a busy road tunnel, and once after a control day with subjects exposed to urban air during normal activities. Peripheral blood was sampled prior to bronchoscopy.
对16名健康受试者在随机顺序下限后进行两种处理，分别为暴露于某繁忙的公路隧道的污染空气2小时，和选择某一天暴露于一般繁忙程度的城市大气中作为对照，14小时后进行支气管镜下支气管粘膜活检和支气管肺泡灌洗（BAL）。在支气管镜检查前抽取外周血样本。
The road tunnel exposures included particulate matter with a 50% cut-off aerodynamic diameter of 2.5 µm, particulate matter with a 50% cut-off aerodynamic diameter of 10 µm and nitrogen dioxide which had median concentrations of 64, 176 and 230 µg•m–3, respectively. Significantly higher numbers of BAL fluid total cell number, lymphocytes and alveolar macrophages were present after road tunnel exposure versus control. Significantly higher nuclear expression of the transcription factor component c-Jun was found in the bronchial epithelium after exposure. No upregulation of adhesion molecules or cellular infiltration was present and blood coagulation factors were unaffected.
公路隧道的暴露因素包括50%的截止空气动力学直径为2.5微米的颗粒物，50%的截止空气动力学直径为10微米的颗粒物和平均浓度分别在64.176和230µg•m–3的二氧化氮。公路隧道暴露组的支气管上皮细胞比对照组具有更高的转录因子组分c-Jun的核表达。未见黏附分子的上调或细胞的浸润，凝血因子未受影响。
In conclusion, exposure of healthy subjects to traffic-related air pollution resulted in a lower airway inflammatory response with cell migration, together with signs of an initiated signal transduction in the bronchial epithelium.
总之，让健康个体暴露于车辆废气中会降低有细胞迁移的气道炎症反应，同时也有迹象显示启动了支气管上皮的信号传导。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-10-30 05:11
医学,生命科学网