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【medical-news】PET identifies inflammation severity in car
11/21/2006
By: Reuters Health
http://www.auntminnie.com/index.asp?Sec=sup&Sub=mol&Pag=dis&ItemId=73605
NEW YORK (Reuters Health), Nov 21 - PET imaging with fluorodeoxyglucose (FDG-PET) can be used to identify noninvasively the degree of inflammation in carotid plaques in patients, according to a report in the November 7th issue of the Journal of the American College of Cardiology.
"Plaque biology can be imaged using PET and may prove to be a stronger predictor of risk than stenosis," Dr. Ahmed Tawakol from Massachusetts General Hospital and Harvard Medical School, Boston, told Reuters Health. "I believe that PET imaging of plaque may prove to be a remarkably powerful way of evaluating the effect of new therapies targeting atherosclerotic diseases."
Dr. Tawakol and colleagues investigated whether inflammation in human carotid arteries could be measured noninvasively in vivo using FDG-PET in 17 adult patients with severe carotid artery stenosis already scheduled to undergo carotid endarterectomy.
The PET signal correlated significantly with macrophage staining in the plaques removed at the time of endarterectomy, the team found.
The correlation was even stronger between FDG uptake and mean inflammation (as measured by mean percentage of CD68 staining), the results indicate.
In contrast, FDG uptake did not correlate significantly with plaque thickness or plaque area, the researchers note.
"The findings of the present study suggest that PET studies of the carotid arteries could aid in the risk stratification of patients with less stenotic or asymptomatic lesions by identifying inflamed plaques that may be associated with a higher risk of a clinical event," the investigators explain.
"Natural history studies are needed to evaluate the clinical relevance of plaque imaging," Dr. Tawakol said. "We are also planning several additional pharmacological intervention studies."
By Will Boggs, M.D.
Last Updated: 2006-11-20 13:39:49 -0400 (Reuters Health)
J Am Coll Cardiol 2006;48:1818-1824. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 PET identifies inflammation severity in carotid plaques
PET可识别颈动脉斑块炎症的严重程度
11/21/2006
By: Reuters Health
http://www.auntminnie.com/index.asp?Sec=sup&Sub=mol&Pag=dis&ItemId=73605
NEW YORK (Reuters Health), Nov 21 - PET imaging with fluorodeoxyglucose (FDG-PET) can be used to identify noninvasively the degree of inflammation in carotid plaques in patients, according to a report in the November 7th issue of the Journal of the American College of Cardiology.
纽约（路透健康）11月21日——据《美国心脏病学会杂志》11月7日刊报道，氟脱氧葡萄糖PET成像（FDG-PET）可用于非侵入性识别患者颈动脉斑块的炎症程度。
"Plaque biology can be imaged using PET and may prove to be a stronger predictor of risk than stenosis," Dr. Ahmed Tawakol from Massachusetts General Hospital and Harvard Medical School, Boston, told Reuters Health. "I believe that PET imaging of plaque may prove to be a remarkably powerful way of evaluating the effect of new therapies targeting atherosclerotic diseases."
来自麻萨诸塞州综合医院和波士顿哈佛大学医学院的Ahmed Tawakol博士对路透健康版表示，“PET成像可以反映斑块的生物学特征，而斑块的生物学特征可被证实是比狭窄更有力的风险预测因素。我认为斑块的PET成像将成为评估治疗动脉粥样硬化疾病的新疗法的有效手段。”
Dr. Tawakol and colleagues investigated whether inflammation in human carotid arteries could be measured noninvasively in vivo using FDG-PET in 17 adult patients with severe carotid artery stenosis already scheduled to undergo carotid endarterectomy.
Tawakol 博士和他的同事们为了明确能否在活体内无创检测人类颈动脉炎症，他们对17位严重颈动脉狭窄已经准备行颈动脉内膜剥离术的成年患者进行了FDG-PET。
The PET signal correlated significantly with macrophage staining in the plaques removed at the time of endarterectomy, the team found.
研究小组发现，PET信号与动脉内膜切除术时去除的斑块内巨噬细胞染色有显著相关性。
The correlation was even stronger between FDG uptake and mean inflammation (as measured by mean percentage of CD68 staining), the results indicate.
结果显示，FDG摄取和平均炎症程度的相关性更加密切（由氯丹染色的平均百分比测量）。
In contrast, FDG uptake did not correlate significantly with plaque thickness or plaque area, the researchers note.
相反，FDG摄取和斑块的厚度或斑块的面积无显著相关性，研究者指出。
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作者:admin@医学,生命科学 2011-02-27 05:11
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