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【Cancer cell】癌症的致命要害：癌细胞的新陈代谢
The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the altered contribution of these organelles to metabolism are closely related. Similarly, the constitutive activation of signaling cascades that stimulate cell growth has a profound impact on anabolic metabolism. Here, we review the peculiarities of tumor cell metabolism that might be taken advantage of for cancer treatment. Specifically, we discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.
http://www.cancercell.org/content/article/abstract?uid=PIIS1535610808001608 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Tumor Cell Metabolism: Cancer's Achilles' Heel
肿瘤细胞新陈代谢：癌症的唯一致命弱点
The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause.
癌症的重要特征是伴随癌细胞固有代谢错综复杂的改变，无论是作为结果还是作为原因。
As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the altered contribution of these organelles to metabolism are closely related.
作为一个例子，癌细胞线粒体对凋亡相关通透的抵抗和这些细胞器对新陈代谢变异的贡献，它们的关系非常密切。
Similarly, the constitutive activation of signaling cascades that stimulate cell growth has a profound impact on anabolic metabolism.
类似的，刺激细胞生长组成性激活的信号传递对同化代谢具有深远的影响。
Here, we review the peculiarities of tumor cell metabolism that might be taken advantage of for cancer treatment.
这里，我们综述一下肿瘤细胞代谢的特性，这可能对癌症治疗有益。
Specifically, we discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.
具体来说，我们将讨论信号转导通路的变化和/或解释癌变细胞代谢重组的酶机理。
肿瘤细胞新陈代谢：癌症的唯一致命弱点
癌症的重要特征是伴随癌细胞固有代谢错综复杂的改变，无论是作为结果还是作为原因。癌细胞线粒体对凋亡相关通透的抵抗和这些细胞器对新陈代谢变异的贡献，它们的关系非常密切，这是其中一个例子。类似的，刺激细胞生长组成性激活的信号传递对同化代谢具有重大的影响。这里，我们综述肿瘤细胞代谢的特性，这可能对癌症治疗有益。具体来说，我们将讨论信号转导通路的变化和/或解释癌变细胞代谢重组的酶机理。(slimaii译) [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-05-05 17:49
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