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【medical-news】身高与前列腺癌风险有关
By Tara Parker-Pope
A man’s risk for prostate cancer appears to increase with his height, a new study shows.
Height appears to play less of a role than other known prostate cancer risk factors like age, family history and race. As a result, men shouldn’t make screening or treatment decisions based on their height. But the findings may open up a new line of scientific inquiry into the causes of prostate cancer.
Researchers from four universities in England studied more than 9,000 men with and without prostate cancer and found that the tallest men had a 19 percent higher risk of developing prostate cancer than shorter men. Using the shortest men as a baseline, the study showed that risk increased 6 percent for every additional 4 inches in height. The report, published in the September issue of Cancer Epidemiology, Biomarkers & Prevention, showed an even stronger association between height and aggressive cancers.
“Compared to other risk factors, the magnitude of the additional risk of being taller is small, and we do not believe that it should interfere with preventive or clinical decisions in managing prostate cancer,” said the study’s lead author, Luisa Zuccolo, of the department of social medicine at the University of Bristol. “But the insight arising from this research is of great scientific interest.”
The increased risk likely is explained by factors associated with height, such as the insulin-like growth factor-1 system, which stimulates cell growth and has been shown to be involved in prostate cancer incidence and progression. The researchers also analyzed 58 other studies and found evidence that greater stature is associated with a modest increase in prostate cancer risk.
A woman’s height also is associated with breast cancer risk. Women who are 5-feet-9 or taller have a small increase in risk of both premenopausal and postmenopausal breast cancer compared to women 5-feet-3 or shorter.
http://well.blogs.nytimes.com/2008/09/04/height-linked-with-prostate-cancer-risk/ 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Height Linked With Prostate Cancer Risk
身高与患前列腺癌的风险有关
By Tara Parker-Pope
A man’s risk for prostate cancer appears to increase with his height, a new study shows.
一个新的研究结果显示：男人患前列腺癌的风险似乎随着他身高的增加而增加。
Height appears to play less of a role than other known prostate cancer risk factors like age, family history and race. As a result, men shouldn’t make screening or treatment decisions based on their height. But the findings may open up a new line of scientific inquiry into the causes of prostate cancer.
与其他已知的前列腺癌的危险因素如年龄，家族病史和种族相比，高度发挥的作用似乎较少。因此，男人不能根据他们的高度作出检查或治疗的决定。但是这个发现可能会打开一个科学探究前列腺癌原因的新的路线。
Researchers from four universities in England studied more than 9,000 men with and without prostate cancer and found that the tallest men had a 19 percent higher risk of developing prostate cancer than shorter men. Using the shortest men as a baseline, the study showed that risk increased 6 percent for every additional 4 inches in height. The report, published in the September issue of Cancer Epidemiology, Biomarkers & Prevention, showed an even stronger association between height and aggressive cancers.
来自英格兰4所大学的研究人员在对有和没有前列腺癌的超过9000名男子的研究后发现最高的男性比矮的男性患前列腺癌的风险增加了19 ％。研究表明，以矮小男性作为基线，每增加4英寸的高度，患前列腺癌的风险增加了6 ％ 。该报告发表在九月份的癌症流行病学问题，生物标记及预防版块，该报告显示了身高与侵略性癌症之间更紧密的联系。
“Compared to other risk factors, the magnitude of the additional risk of being taller is small, and we do not believe that it should interfere with preventive or clinical decisions in managing prostate cancer,” said the study’s lead author, Luisa Zuccolo, of the department of social medicine at the University of Bristol. “But the insight arising from this research is of great scientific interest.”
“比起其他的风险因素，身高增加患病风险的程度很小，而且我们认为在治疗前列腺癌时，它不应该干预预防或临床决定”，该研究报告的主要作者布里斯托尔大学社会医学院的Luisa Zuccolo说，“但是这项研究给一些人带来很大的科学兴趣。”
The increased risk likely is explained by factors associated with height, such as the insulin-like growth factor-1 system, which stimulates cell growth and has been shown to be involved in prostate cancer incidence and progression. The researchers also analyzed 58 other studies and found evidence that greater stature is associated with a modest increase in prostate cancer risk.
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作者:admin@医学,生命科学 2010-10-14 17:11
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