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【drug-news】早孕期使用二甲双胍可能对胎儿是安
Tue Oct 17, 2006 4:27pm ET
NEW YORK (Reuters Health) - Metformin taken by women with polycystic ovary syndrome during the first trimester of pregnancy does not appear to increase the risk of major fetal malformations, and may have a significant protective effect, according to Canadian researchers.
These findings are still preliminary and further studies are needed to confirm the safety of this drug in pregnancy, the researchers stress in their report, published in the September issue of Fertility and Sterility.
Metformin is used, with or without insulin, to treat patients with type 2 diabetes - and it is also used to treat infertility in women with polycystic ovary syndrome. However, the safety of this drug for the fetus has not been established, Dr. Gideon Koren of The Hospital for Sick Children in Toronto, Ontario, and colleagues point out. Furthermore, a similar drug, phenformin, has been shown to cause birth defects.
Polycystic ovary syndrome, the most common hormonal disorder in premenopausal women in the U.S., is caused by the disruption of the reproductive cycle. Features include enlarged ovaries studded with numerous cystic follicles that contain immature eggs; excess hair growth; and obesity. Women with polycystic ovary syndrome have difficulty conceiving and are at risk of diabetes and heart disease.
To further explore the safety of metformin in pregnancy, Koren and colleagues conducted a large review of the medical literature, including eight studies of metformin taken during the first trimester of pregnancy by a total of nearly 500 women with either PCOS or diabetes.
From the pooled data, the malformation rate in the treatment group was 1.7 percent compared with 7.2 percent in disease-matched control subjects who did not receive metformin.
The researchers found that after the data were adjusted for publication bias, metformin had a statistically significant protective effect of 57 percent against major malformations in the fetus.
The investigators caution that the data establishing safety of metformin in pregnancy are still limited. This study considered only major malformations of the fetus. Other studies assessing the incidence of spontaneous abortion, stillbirth, minor abnormalities, intrauterine growth retardation and preterm labor still need to be conducted.
SOURCE: Fertility and Sterility, September 2006.
http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyID=2006-10-17T202717Z_01_KNE773599_RTRUKOC_0_US-METFORMIN-EARLY-PREGNANCY.xml&WTmodLoc=HealthNewsHome_C2_healthNews-4 认领了 Metformin in early pregnancy may be safe for fetus
怀孕早期服用二甲双胍可能对胎儿无害
NEW YORK (Reuters Health) - Metformin taken by women with polycystic ovary syndrome during the first trimester of pregnancy does not appear to increase the risk of major fetal malformations, and may have a significant protective effect, according to Canadian researchers.
These findings are still preliminary and further studies are needed to confirm the safety of this drug in pregnancy, the researchers stress in their report, published in the September issue of Fertility and Sterility.
纽约（路透社健康资讯）— 加拿大研究人员称，多囊卵巢综合征（PCOS）患者在怀孕头三个月内服用二甲双胍并不增加胎儿主要畸形风险，相反还具有明显保护效果。他们的研究结果发表于《生育与不育》九月刊，文中作者强调，这只是初步发现，孕期服用此药是否安全尚需进一步的研究证实。
Metformin is used, with or without insulin, to treat patients with type 2 diabetes - and it is also used to treat infertility in women with polycystic ovary syndrome. However, the safety of this drug for the fetus has not been established, Dr. Gideon Koren of The Hospital for Sick Children in Toronto, Ontario, and colleagues point out. Furthermore, a similar drug, phenformin, has been shown to cause birth defects.
二甲双胍单独或与胰岛素同时应用于治疗二型糖尿病，也用于治疗PCOS患者的不育。多伦多儿童医院 Gideon Koren博士及其同事指出，二甲双胍对胎儿是否安全还未经阐明。此外，另一个同类药物降糖灵已经被证实可以导致先天缺陷。
Polycystic ovary syndrome, the most common hormonal disorder in premenopausal women in the U.S., is caused by the disruption of the reproductive cycle. Features include enlarged ovaries studded with numerous cystic follicles that contain immature eggs; excess hair growth; and obesity. Women with polycystic ovary syndrome have difficulty conceiving and are at risk of diabetes and heart disease.
多囊卵巢综合征是美国绝经前期妇女最常见的内分泌紊乱，因生殖周期中断引起。主要特征为卵巢多囊性增大（许多囊状卵泡，其内含不成熟卵）、多毛和肥胖。患多囊卵巢综合征的妇女很难怀孕，而且患糖尿病和心脏病的风险增大。
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作者:admin@医学,生命科学 2010-12-12 06:42
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