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【medical-news】超声筛查揭示女性的心血管病的未
超声筛查揭示女性的心血管病的未知风险
Sonographic screening can correctly identify women who may be at risk of heart disease or stroke, especially when traditional risk assessment methods fall short, according to a presentation at the 2006 European Society of Cardiology's World Congress of Cardiology in Barcelona, Spain.
根据2006年欧洲心脏病学会世界会议中的一个会议发言，超声筛查可以正确的发现哪些具有心脏病和中风危险的病人，尤其是传统风险估计方法不能达到目的的时候。
While the Framingham risk score (FRS) system correlates well with men who undergo ultrasound examinations of the carotid arteries and other vascular beds, it does not appear to work as well in women, said study author Dr. John Postley, Jr., an assistant clinical professor of medicine at Columbia University in New York City.
John Postley博士，哥伦比亚大学临床医学助教认为：Framingham风险评分系统与经过超声检查发现颈动脉及其它血管床病变存在很好的相关关系，但是对于女性，效果不是很好。
Instead, handheld ultrasound exams can give physicians a better idea as to whether a woman at even the lowest risk for heart disease may still have potential precursors to a heart attack, he said.
相反，便携式超声检查能够让大夫更加清楚的了解低心脏病风险病人是否还有发生心脏病的潜在征兆。
For this study, Postley looked 120 untreated patients, 50 of whom were women. They all underwent sonographic evaluation for the presence and type of carotid and femoral arterial bifurcation plaque (Titan; SonoCalc software, SonoSite, Bothell, WA). Common carotid intimal medial thickness (CIMT) was also measured.
本研究中，Postley检查了120名未经检查的病人，50名是女性。他们都进行超声检查，评估颈动脉和股动脉分叉处的斑块。也对颈总动脉内膜层（CIMT）的厚度进行了评价。
A sonographic exam is capable of detecting differences of one-tenth of a millimeter of thickness of the intimal layer of the artery, Postley explained. The findings on ultrasound were then correlated with the individual's FRS.
According to the results, 72% of the women had low FRS for cardiovascular disease, yet half the women in the study showed evidence of plaque and thickening of the endothelial lining of the carotid artery.
超声检查能够发现动脉内膜层十分之一毫米的差别。然后将超声表现与FRS评分进行相关分析。
根据本研究结果，72%的女性心脏病病人FRS评分较低，但是本研究中半数的女性显示斑块和颈动脉内膜的增厚。
When CIMT measurements were divided according to gender, there was no correlation for average CIMT or maximum CIMT among the women, Postley said, while there was high correlation among the men.
当CIMT测量结果按照性别进行分类后，女性CIMT的平均值与最高值与FRS均无相关性，但是在男性中存在高度的相关性。
"Clearly, a better method for risk-stratifying patients is needed so that preventive treatment can begin for those who need it most," Postley wrote in his poster presentation. "Screening for carotid intimal medial thickness with vascular ultrasound can uncover at-risk patients with greater accuracy than traditional methods, and should allow for earlier intervention to prevent progression of disease."
“很明显，需要一种更好的风险评估方法，以便对哪些最需要治疗的人能够接受预防性治疗”，Postley在她的发言中如是说。“与常规方法相比，颈动脉内膜厚度的超声筛查能够以更高的准确性发现高危人群，从而能够更早的介入这一人群的治疗，阻止病变进展。
"Screening vascular ultrasound analysis produces a different pattern of risk assessment than does traditional Framingham risk analysis, particularly in women," Postley added.
He suggested that using ultrasound as an additional screening tool could identify more women at risk of cardiovascular events.
“血管超声筛查可以获得与传统FRS系统结果不同的高危人群风险模式，尤其是在女性”，Postley补充说。
他提示采用超声做为补充检查手段，能够发现更多的心血管病高危女性人群。
"I would expect that private-care physicians -- either a family doctor or doctors who specifically care for women -- would refer their patients to radiologists to perform these ultrasound studies," he said.
Commenting on the study, Dr. Sid Smith, a professor medicine at the University of North Carolina in Chapel Hill, said more studies were needed before recommendations could be made about ultrasound screening. Smith, who is also a spokesman for the American Heart Association, said that future studies would have to show that the findings of intimal thickening and plaque streak in women do later correlate with adverse events, and that treating these women, on the basis of those findings, reverses the risk.
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作者:admin@医学,生命科学 2010-11-09 05:11
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