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【科普】红酒抗衰老：有据为证
SAN FRANCISCO -- For the first time, scientists have proof in human subjects that a derivative of an ingredient in red wine combats some symptoms of aging. Sirtris Pharmaceuticals announced the results here on Monday at the JPMorgan Healthcare Conference.
Resveratol, naturally found in red wine, stimulates a gene known as SIRT1, which has been linked with extended lifespans in rodents. The new study is the first time similar effects have been replicated in humans.
"We believe that this is the first time that a drug candidate has shown efficacy in a disease of aging by targeting the genes that control aging," said Christoph Westphal, CEO of Sirtris.
Sirtris was co-founded by David Sinclair, a Harvard Medical School researcher, who discovered SIRT1's role in regulating lifespan. His early work was in yeast, and he later showed that stimulating SIRT1 through a calorie-restricted diet helped animals live longer. Then, Sinclair found resveratol, which stimulates the same gene with results similar to calorie-restriction but without the diet. Resveratrol's effects in mice touched off a storm of excitement among people, including Sinclair, who began taking the drug in its over-the-counter form hoping to extend their lifespans.
Sirtris' proprietary formulation of the drug significantly reduced blood sugar in 67 diabetic patients as compared with a placebo group. The results are an important milestone in bringing resveratrol-related drugs to market.
The study, however, ran just 28 days and had conservative goals: to measure whether a resveratol formulation called SRT501, which is five times easier for the body to use than naturally occurring resveratol, was safe and had some activity in humans. Getting the drug through the regulatory process will take until at least 2012, the company said.
The results partially answer skeptics like Steven Austad, a cellular biologist and longevity researcher at the University of Texas, who expressed doubts about the impact of resveratol in humans to Wired News last year after mouse studies showed longevity gains.
"People in the research community tend to think of mice as small little furry humans with long tails, but they're not," Austad said at the time. "We don't know what it will do."
Sirtris can now say it does know what SRT501 does, at least for a small number of patients over a short period of time: It works.
Patients in the trial were given 2,500 or 5,000 milligrams of the drug in liquid form. Both groups had positive outcomes with no side effects. Westphal said during a question-and-answer session following his presentation at the JP Morgan Healthcare Conference that the unusually high doses were necessary because resveratrol is not a very potent molecule.
That's why the company is also working with other molecules -- potential drugs -- that are unrelated to resveratrol but also stimulate the SIRT1 gene. Some of the molecules could be up to 1,000 times more potent than resveratrol, he added.
Still, SRT501 was effective enough that Sirtris is continuing to push the drug through clinical trials.
"Based on the positive results, and the fact that there are a lot of desirable characteristics to SRT501, we've initiated a Phase IIa study combining SRT501 with the most common diabetic drug, metformin," said Westphal. "Those data are back in the second half of this year."
Sirtris had an initial public offering of its stock back in May of 2007 and is up 23 percent since that time. Following the clinical trial announcement, the stock gained 1.5 percent in after-hours trading.
http://www.wired.com/medtech/drugs/news/2008/01/resveratrol
screen.width-333)this.width=screen.width-333" width=228 height=256 title="Click to view full W020061208469768436589.jpg (228 X 256)" border=0 align=absmiddle> 大S一直很推荐红酒面膜
screen.width-333)this.width=screen.width-333" width=250 height=250 title="Click to view full 8405.jpg (250 X 250)" border=0 align=absmiddle> 每一瓶红酒都会有一个故事
在西方，相传古罗马最具有文化含义的酒神巴克斯发明了葡萄酒，成千上万的女性崇拜得几近疯狂。每当酒神出游，身边总是伴随着一群仙女。这些仙女一边痛饮着葡萄酒，一边载歌载舞，由此可见红酒的起源跟女人息息相关。现如今，酒也成了许多女人的心爱之物，不同的是不再是刚猛浓烈的白酒，而是溢满唇香的红酒。
有个酷爱红酒的女人这样说：“白酒归于男人，红酒归于女人。可在历代形成的传统观念里，酒沾染了太多的阳刚之气，惟独红酒例外，它成为了女性的代表。”
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作者:admin@医学,生命科学 2011-07-22 05:14
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