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【medical-news】马凡氏综合征患儿服用Beta受体阻滞
By Will Boggs, MD
NEW YORK (Reuters Health) Feb 14 - Aortic dilatation during childhood in patients with Marfan syndrome can be reduced by beta-blocker therapy, according to a report in the February 1st American Journal of Cardiology.
"You should treat the aortic fragility as soon as possible," Dr. Guillaume Jondeau told Reuters Health, "even if aortic dilatation is not present."
Dr. Jondeau from Hopital Ambroise Pare Assistance-Publique Hopitaux de Paris, France and associates investigated the impact of beta-blocker therapy on the evolution of aortic diameter in 155 children under 12 years with Marfan syndrome. About half were not treated with beta-blockers.
Although baseline aortic diameters were significantly larger in children treated with beta-blockers than in untreated children, aortic diameters were not significantly different by the end of the study.
Aortic root dilatation progressed significantly more slowly in children who received beta-blocker therapy, the authors report, so that by age 18, aortic root diameters were identical to those in the control group.
Valvular heart disease remained largely unchanged during the study, the researchers note, and there were very few events during follow-up.
Three children died and five underwent aortic surgery in the control group, the report indicates, compared with one death and two aortic surgeries in the treatment group.
"This retrospective study strongly suggests that the beneficial effect of beta-blocker therapy, already demonstrated in adults with Marfan syndrome, is also observed in children," the investigators conclude.
"Screening families is crucial to find affected patients who would not know it," Dr. Jondeau emphasized.
Am J Cardiol 2007;99:406-409.
http://www.medscape.com/viewarticle/552239 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 【medical-news】马凡氏综合征患儿服用Beta受体阻滞剂可限制主动脉扩张
By Will Boggs, MD
NEW YORK (Reuters Health) Feb 14 - Aortic dilatation during childhood in patients with Marfan syndrome can be reduced by beta-blocker therapy, according to a report in the February 1st American Journal of Cardiology.
纽约路透社2月14日健康消息---根据发表在2月1日的美国心脏病期刊上的报告，Beta受体阻滞剂治疗可以减少马凡氏综合征住院患儿主动脉扩张。
"You should treat the aortic fragility as soon as possible," Dr. Guillaume Jondeau told Reuters Health, "even if aortic dilatation is not present."
Guillaume Jondeau博士在路透社健康上说：你应该尽可能治疗主动脉扩张，即使它还没有发生。
Dr. Jondeau from Hopital Ambroise Pare Assistance-Publique Hopitaux de Paris, France and associates investigated the impact of beta-blocker therapy on the evolution of aortic diameter in 155 children under 12 years with Marfan syndrome. About half were not treated with beta-blockers.
来自法国巴黎Hopital Ambroise Pare Assistance-Publique Hopitaux 的Jondeau博士和同事们调查了Beta受体阻滞剂治疗对于155位12岁以下的马凡氏综合征患儿主动脉直径进展的影响，其中约一半没有接受Beta受体阻滞剂治疗。
Although baseline aortic diameters were significantly larger in children treated with beta-blockers than in untreated children, aortic diameters were not significantly different by the end of the study.
虽然接受Beta受体阻滞剂治疗的儿童其主动脉直径明显比未接受Beta受体阻滞剂治疗的大，但在研究结束时两组的主动脉直径无显著差异。
Aortic root dilatation progressed significantly more slowly in children who received beta-blocker therapy, the authors report, so that by age 18, aortic root diameters were identical to those in the control group.
作者报告说：在接受Beta受体阻滞剂治疗的儿童中主动脉根扩展程明显较慢，因此在18岁之前，其主动脉根直径与与对照组相同。
Valvular heart disease remained largely unchanged during the study, the researchers note, and there were very few events during follow-up.
研究者注意到：在研究中心脏瓣膜疾病大多没有变化，在随访中也几乎无不良事件。
Three children died and five underwent aortic surgery in the control group, the report indicates, compared with one death and two aortic surgeries in the treatment group.
报告指出：对照组中有3个儿童死亡并且5个接受了主动脉手术，而治疗组有一例死亡和2例接受主动脉手术。
"This retrospective study strongly suggests that the beneficial effect of beta-blocker therapy, already demonstrated in adults with Marfan syndrome, is also observed in children," the investigators conclude.
研究者得出结论：这项回顾性研究,强烈建议, Beta受体阻滞剂治疗的有益作用已经马凡氏综合征成人中得到证实，也同样在儿童中得到了验证。
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作者:admin@医学,生命科学 2011-07-21 18:14
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