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【medical-news】中性粒细胞与淋巴细胞比值与ST段抬
"This ratio showed higher discriminative ability than total white blood cell count," Dr. Julio Nunez from the University of Valencia, Spain, noted in comments to Reuters Health.
Dr. Nunez and colleagues determined the association of N/L maximum value with mortality and compared its predictive ability with total white blood cell maximum count (WBC) in 470 STEMI patients admitted to a single university hospital. Measurements were obtained at admission and daily for the first 96 hours after admission. During a median follow up of 3 years, 106 patients died (22.6%).
"In this study, we showed that N/L-max measured within the first 96 hours after onset of STEMI symptoms carried significant prognostic value for subsequent mortality," the authors report in the March 15 issue of the American Journal of Cardiology.
The mortality rate during follow up in the first quintile of N/L-max was 6.4%. The highest mortality rates were seen in patients in the fourth and fifth quintiles -- 34% and 47.9%, respectively -- which translated to hazard ratios of 2.58 and 4.20, respectively.
"This association remained significant after adjusting for key predictors including age, reperfusion criteria, renal function, and surrogates of myocardial extensions, such as left ventricular dysfunction, systolic blood pressure and Killip's classification," the investigators note.
The overall discriminatory ability of N/L-max was superior to that of WBC-max, they also report.
These findings were not unexpected, Dr. Nunez told Reuters Health, "because inflammation response is associated with adverse prognosis in the setting of acute coronary syndromes, and commonly this response is characterized by neutrophilia and lymphopenia, so N/L seems a better inflammation marker than total white blood cells."
His group hypothesizes that "patients with high N/L ratio during the acute phase of myocardial infarction could be a subgroup with higher benefit from an aggressive treatment."
"Further studies are needed to clarify this point," Dr. Nunez said.
Am J Cardiol 2008;101:747-752. 认领，48小时内未上缴，请其他战友翻译 NEW YORK (Reuters Health) Apr 29 - Results of a study establish that neutrophilia and lymphopenia, expressed as a high neutrophil-to-lymphocyte ratio (N/L), are strongly related to long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI).
纽约（路透社消息）4月29日的一项研究结果表明中性粒细胞（N）和淋巴粒细胞（L），表现为高N/L ，与S T段抬高心肌梗死患者的长期的死亡率有关。
"This ratio showed higher discriminative ability than total white blood cell count," Dr. Julio Nunez from the University of Valencia, Spain, noted in comments to Reuters Health.
西班牙，巴伦西亚大学，Dr. Julio Nunez，在路透社健康评论指出，"N/L较白细胞总数更有能力预测ST段抬高心肌梗死患者的长期的死亡率“，
Dr. Nunez and colleagues determined the association of N/L maximum value with mortality and compared its predictive ability with total white blood cell maximum count (WBC) in 470 STEMI patients admitted to a single university hospital. Measurements were obtained at admission and daily for the first 96 hours after admission. During a median follow up of 3 years, 106 patients died (22.6%).
Dr. Nunez和他的同事研究了470个住入同一所的大学医院的S-T段抬高心梗患者，确定了N /L的最高值与死亡率是有关，并与白细胞最大计总数（ WBC的）比较其预测能力。测量值均在在入院时和首次入院后96小时后获得。随访中位数3年，106例死亡（22.6 ％）。
"In this study, we showed that N/L-max measured within the first 96 hours after onset of STEMI symptoms carried significant prognostic value for subsequent mortality," the authors report in the March 15 issue of the American Journal of Cardiology.
作者在3月15日美国心脏病学杂志报道，“在这项研究中，我们的研究表明S－T段抬高心肌梗死患者发病后出现症状的第一个96小时测量到的N/L最大值，能够与显著预测其随后的死亡率”
The mortality rate during follow up in the first quintile of N/L-max was 6.4%. The highest mortality rates were seen in patients in the fourth and fifth quintiles -- 34% and 47.9%, respectively -- which translated to hazard ratios of 2.58 and 4.20, respectively.
"This association remained significant after adjusting for key predictors including age, reperfusion criteria, renal function, and surrogates of myocardial extensions, such as left ventricular dysfunction, systolic blood pressure and Killip's classification," the investigators note.
"在调整关键的预测因素如年龄，再灌注级别，肾功能，及心肌扩大的的代替指标例如左心功能不全，收缩压和Killip分级后，这种联系仍然很紧密。 ”研究人员指出。
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作者:admin@医学,生命科学 2010-12-08 17:11
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