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【商业翻译】Transcranial Magnetic Stimulation Reduces A
本稿件为《医师报》约稿，署名统一为“丁香”，稿酬按照医师报标准发放。
Transcranial Magnetic Stimulation Reduces Auditory Hallucinations in Schizophrenia
NEW YORK (Reuters Health) Apr 20 - Slow repetitive transcranial magnetic stimulation appears to be an effective treatment for resistant auditory hallucinations in schizophrenic patients, according to results of a meta-analysis published in the March issue of the Journal of Clinical Psychiatry.
"Slow repetitive transcranial magnetic stimulation (rTMS), at a frequency of 1 Hz, has been proposed as a treatment for auditory hallucinations," Dr. Andre Aleman, of the University of Groningen, the Netherlands, and colleagues write. "Several studies have now been reported regarding the efficacy of TMS treatment, but results were inconsistent."
They therefore applied meta-analytic techniques integrate data from 10 trials of rTMS that were sham-controlled and met inclusion criteria. All of the studies targeted the left temporoparietal cortex using 1 Hz rTMS. A total of 212 subjects were included in the studies.
A significant mean weighted effect size was observed for rTMS versus sham across the 10 studies (d = 0.76, p = 0.0001). Significant heterogeneity was observed among individual effect sizes. When only the nine studies that used continuous stimulation were included, the mean effect size increased to 0.88 (p < 0.0001), and heterogeneity disappeared.
The team found no significant effect of rTMS on a composite index of general psychotic symptoms.
On a clinical level, the investigators note, rTMS may be a promising method for reducing the frequency and intensity of auditory hallucinations in treatment-resistant schizophrenic patients.
"On a more fundamental note, the evidence of reduction of hallucinations after magnetic stimulation over the left temporoparietal cortex may yield clues to the pathophysiology of auditory hallucinations," Dr. Aleman's team points out. "That is, the finding that reducing cortical excitability in speech perception areas may interfere with hallucinations suggests aberrant activation of language perception areas as a cause of auditory hallucinations."
J Clin Psychiatry 2007;68:416-421. 认领了。 经颅磁刺激可以减少精神分裂症病人的幻听症状
3月份《临床心理学杂志》上的一篇meta分析文章称，经颅慢速重复性磁信号刺激（rTMS）可以有效控制精神分裂症病人的难治性幻听（纽约路透社，4月20日消息）。
荷兰荷罗纳大学Andre Aleman博士小组指出：“频率1Hz的慢速rTMS可以用来治疗幻听，但是目前的几项rTMS疗法的研究结果不太一致。”
因此他们应用meta分析方法，对符合纳入标准的10项安慰剂对照组的rTMS研究数据进行了整体分析。所有的研究都将左侧颞顶叶皮层作为1Hz rTMS刺激的靶结构，研究对象达212名。
10项研究中，与对照组相比，都观察到了明显的平均加权效应量（d=0.76，p=0.0001）。但不同的效应量内存在较明显的异质性。若只分析9项进行连续刺激的研究时，平均效应量增加到0.88（p<0.0001），异质性也消失。
尚未发现rTMS对其它普通精神症状的治疗效果。
在临床中，rTMS可能在减少难治性精神分裂症病人幻听的频率和程度方面具有广阔的应用前景。
Aleman研究小组还指出，“从一个更基础的层面考虑，rTMS作用于左侧颞顶叶皮层可以缓解幻听，有可能提供幻听的病生理学线索，也就是说，减少语言识别中枢的兴奋性能够减少幻听，提示产生幻听的原因可能是因为语言识别中枢的异常兴奋造成的”。
丁香 Transcranial Magnetic Stimulation Reduces Auditory Hallucinations in Schizophrenia
经颅磁刺激可以减少精神分裂症病人的幻听症状
NEW YORK (Reuters Health) Apr 20 - Slow repetitive transcranial magnetic stimulation appears to be an effective treatment for resistant auditory hallucinations in schizophrenic patients, according to results of a meta-analysis published in the March issue of the Journal of Clinical Psychiatry.
纽约（路透社消息），4月20日消息——发表在3月分临床心理学杂志上的一篇meta分析文章称，经颅慢性重复性磁信号刺激可以有效治疗精神分裂症病人的难治性幻听。
"Slow repetitive transcranial magnetic stimulation (rTMS), at a frequency of 1 Hz, has been proposed as a treatment for auditory hallucinations," Dr. Andre Aleman, of the University of Groningen, the Netherlands, and colleagues write. "Several studies have now been reported regarding the efficacy of TMS treatment, but results were inconsistent."
荷兰荷罗纳大学Andre Aleman博士小组指出：“频率1Hz的慢速重复性经颅磁信号刺激可以用来治疗幻听，目前已有几项关于经颅磁信号刺激疗法的研究，但是结果不太一致。”
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作者:admin@医学,生命科学 2010-11-02 22:43
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