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【文摘发布】运动员肥厚性心肌病的发病率并不
Relevance to Pre-Participation Screening
Sandeep Basavarajaiah, MBBS, MRCP*,, Matthew Wilson, MSc, MPhil, Gregory Whyte, PhD, Ajay Shah, PhD, FRCP*, William McKenna, DSc, FRCP, FESC, FACC and Sanjay Sharma, BSc (Hons), MD, FRCP*,,*
* King’s College Hospital, London, England
University Hospital, London, England
Olympic Medical Institute, London, England
The Heart Hospital, London, England.
Objectives: This study sought to determine the prevalence of hypertrophic cardiomyopathy (HCM) in elite athletes.
Background: Hypertrophic cardiomyopathy is considered to be the most common cause of exercise-related sudden death in young athletes. The prevalence of HCM in elite athletes has never been reported but has important implications with regard to pre-participation screening for the disorder.
Methods: Between 1996 and 2006, 3,500 asymptomatic elite athletes (75% male) with a mean age of 20.5 ± 5.8 years (range 14 to 35 years) underwent 12-lead electrocardiography and 2-dimensional echocardiography. None had a known family history of HCM.
Results: Of the 3,500 athletes, 53 (1.5%) had left ventricular hypertrophy (mean 13.6 ± 0.9, range 13 to 16), and of these 50 had a dilated left ventricular cavity with normal diastolic function to indicate physiological left ventricular hypertrophy. Three (0.08%) athletes with left ventricular hypertrophy had a nondilated left ventricular cavity and associated deep T-wave inversion that could have been consistent with HCM. However, none of the 3 athletes had any other phenotypic features of HCM on further noninvasive testing and none had first-degree relatives with features of HCM. One of the 3 athletes agreed to detrain for 12 weeks, which showed resolution of electrocardiography and echocardiographic changes confirming physiologic left ventricular hypertrophy.
Conclusions: The prevalence of HCM in highly trained athletes is extremely rare. Structural and functional changes associated with HCM naturally select out most individuals from competitive sports. Screening athletes with echocardiography is not cost effective. However, electrocardiography is useful in selecting out those individuals who may have pathological left ventricular hypertrophy for subsequent echocardiography.
J Am Coll Cardiol, 2008; 51:1033-1039, Prevalence of Hypertrophic Cardiomyopathy in Highly Trained Athletes
Relevance to Pre-Participation Screening
肥厚性心肌病在高强度训练的运动员中的发病率
与提前筛选的相关性
Objectives: This study sought to determine the prevalence of hypertrophic cardiomyopathy (HCM) in elite athletes.
目的: 本研究旨在研究肥厚性心肌病在精英运动员中的发病率
Background: Hypertrophic cardiomyopathy is considered to be the most common cause of exercise-related sudden death in young athletes. The prevalence of HCM in elite athletes has never been reported but has important implications with regard to pre-participation screening for the disorder.
背景: 肥厚性心肌病被认为是年轻运动员运动相关性猝死最常见的原因. 而肥厚性心肌病在运动员中的发病率从未有过报道, 而这对于提前筛选此病有重要意义.
Methods: Between 1996 and 2006, 3,500 asymptomatic elite athletes (75% male) with a mean age of 20.5 ± 5.8 years (range 14 to 35 years) underwent 12-lead electrocardiography and 2-dimensional echocardiography. None had a known family history of HCM.
方法: 从1996到2006年间, 3500名无症状精英运动员(75%为男性)接受了12导联心电图和二维超声心动图检查, 这些运动员平均年龄为20.5 ± 5.8岁(14—35岁). 这些运动员中无一人有已知的肥厚性心肌病家族史.
Results: Of the 3,500 athletes, 53 (1.5%) had left ventricular hypertrophy (mean 13.6 ± 0.9, range 13 to 16), and of these 50 had a dilated left ventricular cavity with normal diastolic function to indicate physiological left ventricular hypertrophy.
结果: 在3500名运动员中, 53名(1.5%)有左心室肥厚(平均13.6 ± 0.9, 从13 到16 ), 而这53人中有50人的左心室腔是扩大的, 但舒张功能正常, 表明是生理性的左心室肥厚.
Three (0.08%) athletes with left ventricular hypertrophy had a nondilated left ventricular cavity and associated deep T-wave inversion that could have been consistent with HCM. However, none of the 3 athletes had any other phenotypic features of HCM on further noninvasive testing and none had first-degree relatives with features of HCM.
另有3名(0.08%)左心室肥厚的运动员的左心室腔没有扩大, 并且有相关的深而倒的T波, 这些表现可能符合肥厚性心肌病. 然而, 通过进一步的无创伤性检查, 这3个人都没有表现出肥厚性心肌病的其它表现特征, 并且无一人与肥厚性心肌病的特征呈一级相关.
One of the 3 athletes agreed to detrain for 12 weeks, which showed resolution of electrocardiography and echocardiographic changes confirming physiologic left ventricular hypertrophy.
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作者:admin@医学,生命科学 2011-03-26 05:14
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