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【JACC】胸主动脉瘤：临床相关争论和不确定因素
1. This paper addresses clinical controversies and uncertainties regarding thoracic aortic aneurysm and its treatment.
2. The most recent data available from the Centers for Disease Control and Prevention indicate that aneurysm disease is the 18th most common cause of death in all individuals and the 15th most common in individuals older than age 65 years, accounting for 13,843 and 11,147 deaths in these two groups, respectively.
3. Estimating true aortic size is confounded by obliquity, asymmetry, and noncorresponding sites.
4. It is also important to remember that size is not the only important imaging criterion; shape matters as well, especially loss of the normal 搘aist� of the aorta at the sinotubular junction.
5. Although a virulent disease, thoracic aortic aneurysm is an indolent process. The thoracic aorta grows very slowly梐t approximately 0.1 cm per year.
6. Symptomatic aneurysms should be resected regardless of size. It is important to intervene before the aorta reaches 6 cm in the ascending aorta and 7 cm in the descending aorta. Available data suggest that aneurysms in the ascending aorta need corrective surgery when the artery balloons to 5.5 cm.
7. A full spectrum of engineering calculations regarding the mechanical properties of the dilated aorta can be determined via measurement of six independent variables: aortic pressure in systole and diastole, aortic diameter in systole and diastole, and aortic wall thickness in systole and diastole, and may help optimize timing of surgery.
8. Recent evidence shows that many dissections are preceded by a specific severe exertional or emotional event. Findings that acute exertion and emotion often underlie the onset of acute aortic dissection constitute another reasonable rationale for beta-blocker therapy, with the intent of blunting pressure spikes.
9. Thoracic aortic aneurysm is multigenetic; consequently, no easy, comprehensive, full aortic genetic screen is currently generally available.
10. The decision to treat an aneurysm must be made with the same rigor for endovascular therapy as for open surgical therapy. The presence of a small thoracic aneurysm is not a valid indication for endovascular therapy just because stent therapy is available.
http://content.onlinejacc.org/cgi/content/short/55/9/841 本人已认领该文编译，48小时内若未提交译文，请其他战友自由认领！ 1. This paper addresses clinical controversies and uncertainties regarding thoracic aortic aneurysm and its treatment.
1、本文关于胸主动脉瘤及其治疗的临床相关争论和不确定性因素。
2. The most recent data available from the Centers for Disease Control and Prevention indicate that aneurysm disease is the 18th most common cause of death in all individuals and the 15th most common in individuals older than age 65 years, accounting for 13,843 and 11,147 deaths in these two groups, respectively.
2、来自疾病控制预防中心的最新数据表明，动脉瘤疾病是所有个体第18大常见死因，并且是年龄超过65岁的个体的第15大常见死因，在这两种人群中该种疾病引起的死亡人数分别13843个、11147个。
3. Estimating true aortic size is confounded by obliquity, asymmetry, and noncorresponding sites.
3、估计真正的动脉大小常常会被倾斜度、不对称性和不适应的位置所混乱。
4. It is also important to remember that size is not the only important imaging criterion; shape matters as well, especially loss of the normal 搘aist� of the aorta at the sinotubular junction.
4、我们也应该清楚知道的是成像标准并不单单动脉的大小重要，形状物质也很重要，特别是失去正常的大动脉窦管交界。
5. Although a virulent disease, thoracic aortic aneurysm is an indolent process. The thoracic aorta grows very slowly梐t approximately 0.1 cm per year.
5、尽管胸主动脉瘤是个致命性疾病，但是它仍是个缓慢的病变过程。胸主动脉生长非常缓慢，大约每年以0.1cm的速度进展。
6. Symptomatic aneurysms should be resected regardless of size. It is important to intervene before the aorta reaches 6 cm in the ascending aorta and 7 cm in the descending aorta. Available data suggest that aneurysms in the ascending aorta need corrective surgery when the artery balloons to 5.5 cm.
6、有症状的微动脉瘤都被应该切除不管动脉瘤的大小。在升主动脉达到6cm、降主动脉达到7cm以前进行干预是非常重要的。从获得的数据来看，升主动脉的微动脉瘤需要矫形外科治疗当动脉膨胀到5.5cm。
7. A full spectrum of engineering calculations regarding the mechanical properties of the dilated aorta can be determined via measurement of six independent variables: aortic pressure in systole and diastole, aortic diameter in systole and diastole, and aortic wall thickness in systole and diastole, and may help optimize timing of surgery.
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作者:admin@医学,生命科学 2011-03-01 23:42
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