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【Mol Pharm】可卡因疫苗研制成功
Cocaine Analog Coupled to Disrupted Adenovirus: A Vaccine Strategy to Evoke High-titer Immunity Against Addictive Drugs
Molecular Therapy , (4 January 2011) | doi:10.1038/mt.2010.280
http://www.nature.com/mt/journal/vaop/ncurrent/pdf/mt2010280a.pdf
Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1?E3? adenovirus (Ad) gene transfer vectors are potent immunogens, we have developed a novel vaccine platform for addictive drugs by covalently linking a cocaine analog to the capsid proteins of noninfectious, disrupted Ad vector. The Ad-based anticocaine vaccine evokes high-titer anticocaine antibodies in mice sufficient to completely reverse, on a persistent basis, the hyperlocomotor activity induced by intravenous administration of cocaine.
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Cocaine vaccine could make drug addiction a distant memory
http://io9.com/5725864/cocaine-vaccine-could-make-drug-addiction-a-distant-memory
The first ever vaccine for drug addiction has just been created. By combining a cocaine-like molecule with part of the common cold virus, you get a vaccine that turns the immune system against cocaine, keeping it away from the brain.
So far, the vaccine has only been tested on mice, but the results are extraordinary. Mice given the vaccine no longer exhibited any of the hyperactive signs of a cocaine high when they were next given the drug. The vaccine was created by taking just the part of the cold virus that alerts the body's immune system to its presence, and then researchers connected the signalling mechanism to a more stable version of the cocaine molecule.
Once the mice received an injection of the vaccine, they started producing anti-cocaine antibodies which targeted and destroyed any cocaine that then entered their system. Normally, cocaine does not produce an immune response, leaving it free to wreak havoc on the brain and body of whoever takes it. But the cold virus segments taught the immune system to treat cocaine like a hostile invader, offering a nearly impregnable wall of protection from the cocaine's effects.
Researcher Ronald Crystal explains what this means:
"Our very dramatic data shows that we can protect mice against the effects of cocaine, and we think this approach could be very promising in fighting addiction in humans. While other attempts at producing immunity against cocaine have been tried, this is the first that will likely not require multiple, expensive infusions, and that can move quickly into human trials. There is currently no FDA (Food and Drug Administration) approved vaccine for any drug addiction.The vaccine may help [drug addicts] kick the habit, because if they use cocaine, an immune response will destroy the drug before it reaches the brain's pleasure center.
我的评
1
2003年就有戒烟疫苗转而戒除毒瘾的想法，不过没有下文
http://news.sina.com.cn/w/2003-09-10/1549727389s.shtml
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2008年01利用霍乱弧菌研究可卡因疫苗，不过没有下文
http://www.sichuandaily.com.cn/2008/01/03/20080103729254173324.htm
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这次是利用更小的流感病毒，在小鼠实验上效果明显。非常聪明的设计，对于BBB的穿透力也更好。更重要的是，注射即可，操作简单可以普遍适用，大批量生产会便宜。 欢迎大家积极提供生物及生命工程信息 - 业界热点资讯版 - 爱爱...每日动态报道 2010年11月11日 默克准备豪赌提升HDL新药,如果成功可能创造比立普妥... Alternate Endings: A New Story for mRNA Decapping Mol Cell PubMed (12 Nov ...www.iiyi.com/...3-1791415.html-2010-12-24-快照-生命工程信息 - 业界热点资讯版 - 爱爱..."[标签:content2]
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作者:admin@医学,生命科学 2011-01-11 00:45
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