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【medical-news】NIP-一种新的促肿瘤形成蛋白
Proteins that when expressed out of context cause a cell to become cancerous are known as oncogenic proteins. Qimin Zhan and colleagues, at the Chinese Academy of Medical Sciences and Peking Union Medical College, People's Republic of China, have now identified in mice a new oncogenic protein that is also expressed at elevated levels in human breast cancers and lung carcinomas.
In the study, Nlp was found to be expressed at elevated levels in the majority of human breast and lung cancers analyzed. In the lung cancers analyzed, these high protein levels were a result of NLP gene amplification. In vitro analysis of the function of Nlp indicated that it conferred on cells tumorigenic properties, suggesting that it was an oncogenic protein. Consistent with this, mice engineered to overexpress Nlp spontaneously developed tumorigenesis in the breast, ovary, and testicle. The authors therefore suggest that Nlp abnormalities might lead to tumor formation and development.
TITLE: Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice
AUTHOR CONTACT:
Qimin Zhan
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
View this article at: http://www.jci.org/articles/view/39447?key=a475f34512aaf559304f 本人认领此文，若48小时未提交，请其他战友认领。 ONCOLOGY: Nlp: all new tumor-forming protein
肿瘤学：Nip：一种新的肿瘤形成蛋白
Proteins that when expressed out of context cause a cell to become cancerous are known as oncogenic proteins. Qimin Zhan and colleagues, at the Chinese Academy of Medical Sciences and Peking Union Medical College, People's Republic of China, have now identified in mice a new oncogenic protein that is also expressed at elevated levels in human breast cancers and lung carcinomas.
能是正常细胞变成癌细胞的蛋白成为原癌蛋白。中国医学科学院和中国协和医科大学的Qimin Zhan及其同事在小鼠上发现了一种新的原癌蛋白，该蛋白在人乳腺癌和肺癌中表达增高。
In the study, Nlp was found to be expressed at elevated levels in the majority of human breast and lung cancers analyzed. In the lung cancers analyzed, these high protein levels were a result of NLP gene amplification. In vitro analysis of the function of Nlp indicated that it conferred on cells tumorigenic properties, suggesting that it was an oncogenic protein. Consistent with this, mice engineered to overexpress Nlp spontaneously developed tumorigenesis in the breast, ovary, and testicle. The authors therefore suggest that Nlp abnormalities might lead to tumor formation and development.
该项研究发现Nlp在大多数人被检测的乳腺和肺癌组织中表达增高。在被研究的肺癌中，Nlp蛋白表达增高是由于NLP基因扩增的结果。通过体外对Nlp功能研究显示它可使细胞癌变，提示这是一种原癌蛋白。与体外研究相符的是当利用基因工程技术过表达Nlp的小鼠能自发性地在乳腺、卵巢和睾丸上形成肿瘤。作者因此认为Nlp异常可导致肿瘤形成和发生。
TITLE: Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice
题目：中心体Nlp是一种在人类肿瘤中可发生基因扩增的原癌蛋白，在转基因鼠中可致自发性肿瘤发生 肿瘤学：Nlp：一种新的肿瘤形成蛋白
能是正常细胞变成癌细胞的蛋白成为原癌蛋白。中国医学科学院和中国协和医科大学的Qimin Zhan及其同事在小鼠上发现了一种新的原癌蛋白，该蛋白在人乳腺癌和肺癌中表达增高。
该项研究发现Nlp在大多数人被检测的乳腺和肺癌组织中表达增高。在被研究的肺癌中，Nlp蛋白表达增高是由于NLP基因扩增的结果。通过体外对Nlp功能研究显示它可使细胞癌变，提示这是一种原癌蛋白。与体外研究相符的是当利用基因工程技术过表达Nlp的小鼠能自发性地在乳腺、卵巢和睾丸上形成肿瘤。作者因此认为Nlp异常可导致肿瘤形成和发生。
题目：中心体Nlp是一种在人类肿瘤中可发生基因扩增的原癌蛋白，在转基因鼠中可致自发性肿瘤发生 应该是Nlp不是Nip吧，NIP是BCL-2家族的，应该不是新蛋白了 【medical-news】NIP-一种新的促肿瘤形成蛋白 - 医药生命科学...发表时间：2010-2-7回帖数：4oncology: nlp: all new tumor-forming protein proteins that when expressed out of ... 能是正常细胞变成癌细胞的蛋白成为原癌蛋白.中国医学科学院和中国协和医科大学的qimin ...www.ruanjian520.com/thread-... - 2010-02-07-快照-医药生命科学..." 医药生命科学动态跟踪 -人才效应在清华生命科学学科迸发 davai 【drug-news】Teva公司向海地捐赠价值700万... 【medical-news】研究显示了肿瘤细胞是如何“击败”药物 绿豆 【NEJM】Googling ...www.ruanjian520.com/...82.html-2010-02-07-快照-医药生命科学动态跟踪 -"[标签:content2]
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作者:admin@医学,生命科学 2011-01-10 11:02
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