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【Gastroenterology】肥胖者易患结肠腺瘤
August 22, 2008 — Obesity is associated with the risk for colorectal adenoma, and body weight reduction is suggested to decrease this risk, according to the results of a retrospective cohort study reported in the August issue of the American Journal of Gastroenterology.
"Obesity is thought to be associated with colorectal cancer and adenoma," write Yutaka Yamaji, MD, from the University of Tokyo in Japan, and colleagues. "We aimed to investigate the effect of body weight on the risk of colorectal adenoma both in cross-sectional and longitudinal analyses."
At a large-scale health appraisal institution in Japan, 7963 asymptomatic, average-risk Japanese adults were enrolled at initial examinations, and 2568 of these participants had a second colonoscopy 1 year later. The association between body mass index (BMI) at the initial examination and the prevalence of colorectal adenoma was determined as was the relationship between the incidence of colorectal adenoma at the second colonoscopy and the initial BMI and body weight changes during the year.
Increases in the prevalence of colorectal adenoma were linked to increases in BMI quartiles: 15.4%, 20.6%, 22.7%, and 24.2%, respectively, in the first (BMI < 21.350 kg/m2), second (BMI 21.350 ≤ BMI < 23.199 kg/m2), third (BMI 23.199 ≤ BMI < 25.156 kg/m2), and fourth (BMI ≤ 25.156 kg/m2) quartiles. Compared with the first quartile, adjusted odds ratios (ORs) were 1.15 (95% confidence interval [CI], 0.97 - 1.37; P = .10) for the second quartile, 1.19 (95% CI, 1.01 - 1.41; P = .04) for the third quartile, and 1.32 (95% CI, 1.12 - 1.56; P = .001) for the fourth quartile.
The incidence rates of colorectal adenoma after 1 year also increased proportionally based on the initial BMI, with incidence rates of 12.9% for the first quartile, 15.7% for the second quartile, 18.3% for the third quartile, and 19.0% for the fourth quartile.
Among the highest initial BMI groups that had weight reduction during the year, the incidence of adenoma decreased below that of the lowest BMI group without weight reduction.
"Obesity was associated with the risk for colorectal adenoma, and body weight reduction was suggested to decrease this risk," the study authors write.
Limitations of this study include lack of data on lifestyle factors other than BMI, reasons and methods for weight reduction varied and not systematically controlled or investigated, and short interval of colonoscopies.
"The present study supported that obesity is a risk factor for colorectal adenoma," the study authors write. "Our results suggest the possibility of decreasing the risk for colorectal neoplasm by controlling body weight."
This study received no external funding. The study authors have disclosed no relevant financial relationships. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Obesity Linked to Risk for Colorectal Adenoma
肥胖者易患结直肠腺瘤
August 22, 2008 — Obesity is associated with the risk for colorectal adenoma, and body weight reduction is suggested to decrease this risk, according to the results of a retrospective cohort study reported in the August issue of the American Journal of Gastroenterology.
2008年8月22日——根据美国胃肠病学杂志第8期发表的一篇回顾性研究显示，肥胖与结直肠腺瘤的危险性密切相关，体重下降者发生腺瘤的危险性降低。
"Obesity is thought to be associated with colorectal cancer and adenoma," write Yutaka Yamaji, MD, from the University of Tokyo in Japan, and colleagues. "We aimed to investigate the effect of body weight on the risk of colorectal adenoma both in cross-sectional and longitudinal analyses."
“肥胖被认为与结直肠癌和腺瘤有关。”来自于日本东京大学的Yutaka Yamaji博士及其同事说：“我们目的是从横向和纵向上分析体重对结直肠腺瘤的危险性的影响。”
At a large-scale health appraisal institution in Japan, 7963 asymptomatic, average-risk Japanese adults were enrolled at initial examinations, and 2568 of these participants had a second colonoscopy 1 year later. The association between body mass index (BMI) at the initial examination and the prevalence of colorectal adenoma was determined as was the relationship between the incidence of colorectal adenoma at the second colonoscopy and the initial BMI and body weight changes during the year.
在日本一个大型的健康鉴定机构，研究者对7963例无症状，中等危险的日本成人进行了首次检查，其中2568例在1年后进行了第2次结肠镜检查。结果发现在第1次检查时已明确的体重指数（BMI）与结直肠腺瘤的相关性，在一年内第2次结肠镜检查时结直肠腺瘤的发生率和初次的BMI和体重变化有关。
Increases in the prevalence of colorectal adenoma were linked to increases in BMI quartiles: 15.4%, 20.6%, 22.7%, and 24.2%, respectively, in the first (BMI < 21.350 kg/m2), second (BMI 21.350 ≤ BMI < 23.199 kg/m2), third (BMI 23.199 ≤ BMI < 25.156 kg/m2), and fourth (BMI ≤ 25.156 kg/m2) quartiles. Compared with the first quartile, adjusted odds ratios (ORs) were 1.15 (95% confidence interval [CI], 0.97 - 1.37; P = .10) for the second quartile, 1.19 (95% CI, 1.01 - 1.41; P = .04) for the third quartile, and 1.32 (95% CI, 1.12 - 1.56; P = .001) for the fourth quartile.
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作者:admin@医学,生命科学 2010-11-07 05:11
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