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【medical-news】研究者发现抗氧化添加剂与患黑色
研究者发现抗氧化添加剂与患黑色素瘤风险之间无相关
The Tan Sheet. 2009 Aug 24, MA Moon
Antioxidant supplements do not appear to increase the risk of melanoma, according to researchers who studied the issue following an earlier report that pointed to an increased risk for women.
In a large, population-based study, none of the exposure variables - overall antioxidant use, duration of use over the past 10 years, total dosage expressed in pill-years, or years of adult use during adulthood - correlated with melanoma risk in either men or women, said researchers led by Maryam M. Asgari of Kaiser Permanente Northern California, Oakland.
They undertook this study because the Supplementation in Vitamins and Mineral Antioxidants primary prevention trial published in 2007 found that daily oral supplementation with a combination of antioxidants raised the incidence of melanoma in women.
The SUVIMAX findings were alarming, given that an estimated 48 percent to 55 percent of U.S. adults use supplements regularly, Asgari and her colleagues wrote in the August issue of the Archives of Dermatology.
In their study, Asgari's team examined antioxidant use among 69,671 adults who answered a 24-page questionnaire regarding health history, lifestyle factors, diet, supplement use and cancer-risk factors.
They focused on the five antioxidants assessed in the SUVIMAX trial - vitamin E, vitamin C, beta-carotene, zinc, selenium, or a placebo - that the subjects in the cohort also identified.
Most of the cohort subjects, 66 percent, were either current or former users of multivitamins.
During seven years of follow-up, 461 incident cases of cutaneous melanoma were found. But antioxidants were not associated with the disease.
"Specifically, in the highest dose category of multivitamins ... there was no increased risk of melanoma. Results were similar in men and women," the investigators wrote.
Moreover, since many people take multivitamins plus additional beta carotene and selenium supplements, long-term use of comparably high daily doses of these two nutrients - 100 ?g of selenium and 6000 ?g of beta carotene - were tested in a separate analysis.
Again, no increased risk of melanoma was found and the results were the same for women and men, according to the study.
Asgari and her associates wrote it is likely that the SUVIMAX findings "could be explained by methodological shortcomings."
In SUVIMAX, subjects answered only a single question pertaining to their lifetime sun exposure, and "the analysis was based on only 16 cases" of melanoma.
In addition, the incidence of melanoma in the SUVIMAX population was only 25 cases per 100,000 person-years - one-fifth the rate in the current study.
SUVIMAX, conducted in France, was the first study to demonstrate dietary supplements reduce both total mortality and the likelihood of developing cancer in Western populations, according to the European Union Food Information Council.
Researchers in the eight-year, double-blind trial collected diet and health information and blood samples from 5,000 men and 8,000 women. The participants were split into two groups and given either a cocktail of antioxidants comprising vitamins E and C, beta-carotene, zinc and selenium, or a placebo.
The EU agency also said SUVIMAX was "distinguished" because it used "realistic levels of antioxidant vitamins and minerals, such as might be obtained naturally through a balanced diet rich in fruit and vegetables, rather than mega-doses which have failed to demonstrate any benefit in many previous studies."
The work of Asgari and her associates was supported in part by the National Institute of Arthritis, Musculoskeletal and Skin Diseases and the National Cancer Institute. No financial conflicts of interest were reported.
http://www.oncologystat.com/news 初译：
Researchers Find No Link Between Antioxidant Supplements, Melanoma Risk
研究者发现抗氧化添加剂与患黑色素瘤风险之间无相关
The Tan Sheet. 2009 Aug 24, MA Moon
Antioxidant supplements do not appear to increase the risk of melanoma, according to researchers who studied the issue following an earlier report that pointed to an increased risk for women.
根据研究人员的研究发现，抗氧化剂并不会增加患黑色素瘤的风险，这与之前发表的一篇文章的观点恰恰相反，那篇文章认为抗氧化剂存在增加妇女患黑色素瘤的风险。
In a large, population-based study, none of the exposure variables - overall antioxidant use, duration of use over the past 10 years, total dosage expressed in pill-years, or years of adult use during adulthood - correlated with melanoma risk in either men or women, said researchers led by Maryam M. Asgari of Kaiser Permanente Northern California, Oakland.
在一项大的，基于人口的研究中，所有包括的变数——所有抗氧化剂的使用，在过去的10年里的使用时间，服用期间的总药量或者成年后使用年数——不管对于男性或者女性来说都与黑色素瘤没有联系。由来自奥克兰北加州凯泽永久的Maryam M. Asgari所领导的研究人员说。
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作者:admin@医学,生命科学 2010-10-15 05:11
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