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【medical-news】流感注射可轻微增加格-巴二氏综合
Flu shot slightly raises risk of Guillain-Barre
Updated Mon. Nov. 13 2006 5:09 PM ET
CTV.ca News Staff
New research suggests a very small increased risk of developing the potentially disabling neurological disorder Guillain-Barré Syndrome (GBS) after receiving the flu vaccine.
However, the Canadian researchers behind the study are quick to warn that in patients at high risk of complications from the flu, the benefits of vaccination far outweigh the risk.
"This is a disease that occurs sporadically, maybe about 10 people per million," the study's lead author, Dr. David Juurlink, told CTV News' Avis Favaro.
"If you vaccinated all of those million people maybe one or two additional cases of Guillain-Barré Syndrome would develop as a result of the vaccine."
Juurlink compared the slight risk of getting GBS from the vaccine to being struck by lightning.
The study tracked adults who received the vaccine during the months of October and November between April 1, 1992 and March 31, 2004.
"We found that receipt of the flu vaccine was associated with an increased risk with developing the Guillain-Barré Syndrome in roughly the two months after vaccination," said Juurlink.
GBS can cause paralysis and in some cases can even be deadly.
"It starts typically as a tingling in the lower extremities, muscle weakness develops and for some people it becomes a mild illness that gets better after a few weeks," said Juurlink. "But there are certain variants that can become paralyzing the muscles of respiration, leaving people debilitated on breathing machines."
Despite the risks, Juurlink said if people stop taking the flu vaccine the consequences would be much more calamitous.
"Millions of Canadians get influenza ever year and by vaccinating people we can prevent hundreds of thousands of cases of influenza, thousands of hospital admissions and probably thousands of deaths," he said.
"For me it's a no-brainer, I've got my flu vaccine and I get my patients to get theirs as well."
In a second analysis, the same researchers found no significant increase in GBS hospital admissions after Ontario implemented its universal influenza immunization program in 2000.
Despite all the research, doctors are unable to identify who is most likely to develop GBS.
"Because we don't know exactly why it happens we can't identify the person that's most at risk," said Juurlink.
The full report can be found in the November 13, 2006 issue of the Archives of Internal Medicine. 本人已经认领此文. 如在48小时内未能提交译文, 其他战友可自由认领. 流感疫苗轻微增加格林巴利综合征风险
New research suggests a very small increased risk of developing the potentially disabling neurological disorder Guillain-Barré Syndrome (GBS) after receiving the flu vaccine.
加拿大的研究人员的最新研究提示，接种流感疫苗后，格林巴利综合征(GBS)风险轻度增高，这是一种可能引起残疾的神经系统疾病。
However, the Canadian researchers behind the study are quick to warn that in patients at high risk of complications from the flu, the benefits of vaccination far outweigh the risk.
不过他们随即称，对于那些可能发生流感并发症的病人来说，接种疫苗的好处要远远超过这种危险。
"This is a disease that occurs sporadically, maybe about 10 people per million," the study's lead author, Dr. David Juurlink, told CTV News' Avis Favaro.
"If you vaccinated all of those million people maybe one or two additional cases of Guillain-Barré Syndrome would develop as a result of the vaccine."
研究领导人、David Juurlink博士接受采访时说，GBS是一种散发性疾病，发病率大约是每100万人中10人。如果给100万人接种流感疫苗，可能会因此多出来1到2名GBS患者。
Juurlink compared the slight risk of getting GBS from the vaccine to being struck by lightning.
The study tracked adults who received the vaccine during the months of October and November between April 1, 1992 and March 31, 2004.
Juurlink将疫苗导致GBS的风险比喻为遭受雷击的几率。他们追踪了1992年4月1日至2004年3月31日、在10月到11月期间接种疫苗的成人。
"We found that receipt of the flu vaccine was associated with an increased risk with developing the Guillain-Barré Syndrome in roughly the two months after vaccination," said Juurlink.
他们发现，接种疫苗约两月后时，流感疫苗接种者与GBS发病风险轻微增高有关。
GBS can cause paralysis and in some cases can even be deadly.
"It starts typically as a tingling in the lower extremities, muscle weakness develops and for some people it becomes a mild illness that gets better after a few weeks," said Juurlink. "But there are certain variants that can become paralyzing the muscles of respiration, leaving people debilitated on breathing machines."
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作者:admin@医学,生命科学 2010-10-14 17:11
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