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美研究称高血压部分可能属于炎症
波士顿布莱根妇女医院（Brigham and Women's Hospital，BWH）在报告中称，这项结论是根据血蛋白为炎症的指标，似乎也是高血压的预报器而归纳出来的。
这项研究发表在本周的《美国医学会杂志》（Journal of the American Medical Association）上，主要作者塞索（Howard Sesso）表示：“这使最初的预防变得困难。这项研究获得的数据令人振奋，因为它们是首度出现的重要证明，显示C反应蛋白（C-reactive protein）含量可能有助于我们预测罹患高血压的风险。”
文中称，C反应蛋白含量的增加与免疫系统的长期活化有关，也被视为一种炎症反应。
文中说，这些研究人员已经发现，炎症在心脏病的形成中扮演重要角色，而可以藉简单、低廉的验血，检测惹事生非的C反应蛋白含量，轻易检查出炎症的情形。
JAMA. 2003;290:2945-2951.
C-Reactive Protein and the Risk of Developing Hypertension
Howard D. Sesso; Julie E. Buring; Nader Rifai; Gavin J. Blake; J. Michael Gaziano; Paul M. Ridker
Department of Medicine, Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, and Department of Medicine, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital and Harvard Medical School; Department of Epidemiology, Harvard School of Public Health; and Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, Mass.
Context: Although it has been hypothesized that hypertension is in part an inflammatory disorder, clinical data linking inflammation with incident hypertension are scarce. Objective: To examine whether C-reactive protein levels, a marker of systemic inflammation, are associated with incident hypertension. Design, Setting, and Participants: A prospective cohort study that began in 1992 of 20 525 female US health professionals aged 45 years or older who provided baseline blood samples with initially normal levels of blood pressure (BP) (systolic BP <140 mm Hg and diastolic BP <90 mm Hg, and no history of hypertension or antihypertensive medications) and then followed up for a median of 7.8 years for the development of incident hypertension. Plasma C-reactive protein levels were measured and baseline coronary risk factors were collected. Main Outcome Measure: Incident hypertension, defined as either a new physician diagnosis, the initiation of antihypertensive treatment, or self-reported systolic BP of at least 140 mm Hg or a diastolic BP of at least 90 mm Hg. Results: During follow-up, 5365 women developed incident hypertension. In crude models, the relative risks (RRs) and 95% confidence intervals (CIs) of developing hypertension from the lowest (referent) to the highest levels of baseline C-reactive protein were 1.00, 1.25 (95% CI, 1.14-1.40), 1.51 (95% CI, 1.35-1.68), 1.90 (95% CI, 1.72-2.11), and 2.50 (95% CI, 2.27-2.75) (linear trend P<.001). In fully adjusted models for coronary risk factors, the RRs and 95% CIs were 1.00, 1.07 (95% CI, 0.95-1.20), 1.17 (95% CI, 1.04-1.31), 1.30 (95% CI, 1.17-1.45), and 1.52 (95% CI, 1.36-1.69) (linear trend P<.001). C-reactive protein was significantly associated with an increased risk of developing hypertension in all prespecified subgroups evaluated, including those with very low levels of baseline BP, as well as those with no traditional coronary risk factors. Similar results were found when treating C-reactive protein as a continuous variable and controlling for baseline BP. Conclusion: C-reactive protein levels are associated with future development of hypertension, which suggests that hypertension is in part an inflammatory disorder.
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作者:admin@医学,生命科学 2011-06-28 17:57
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