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【medical-news】肾小球高滤过：代谢综合征风险的
Author：Tomaszewski M, Charchar FJ, Maric C, McClure J, Crawford L,Grzeszczak W, Sattar N, Zukowska-Szczechowska E, Dominiczak AF.
Resource: Kidney Int. 2007 Feb 28; [Epub ahead of print]
Abstract：Chronic kidney disease coexists with metabolic syndrome and this relationship may be apparent before overt manifestations of cardiovascular disease. To investigate early stages of the natural history of associations between renal function and metabolic syndrome, we phenotyped 1572 young (mean age=18.4 years), apparently healthy men for metabolic risk factors and estimated their creatinine clearance based on the Cockcroft-Gault equation. High metabolic risk (clustering of at least three metabolic risk factors) was revealed in 8.7% (137) of the subjects and was associated with a 6.9-fold increase in the odds of glomerular hyperfiltration (95% confidence interval (CI): 3.9-11.5) when compared to reference (from none to two metabolic risk factors). Overweight, elevated blood pressure, and low high-density lipoprotein (HDL) cholesterol increased the multivariate-adjusted odds ratio of glomerular hyperfiltration to 6.6 (95% CI: 3.8-11.6), 1.8 (95% CI: 1.0-3.0), and 2.5 (95% CI: 1.5-4.3), respectively. Systolic and diastolic blood pressures clustered together with leptin in the factor analysis and this blood pressure-adiposity component correlated with estimated creatinine clearance (r=0.329, P<0.0001) and explained on its own 10.2% of the variance in the estimated renal function. Our data reveal the silent epidemics of metabolic risk among young, apparently healthy men. Furthermore, the results indicate that high metabolic risk is associated with glomerular hyper filtration before overt manifestations of cardiovascular disease.
PMID: 17332732 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：Glomerular hyperfiltration: A new marker of metabolic risk.
题目：肾小球高滤过：代谢综合症风险的新标志
Author：Tomaszewski M, Charchar FJ, Maric C, McClure J, Crawford L,Grzeszczak W, Sattar N, Zukowska-Szczechowska E, Dominiczak AF.
Resource: Kidney Int. 2007 Feb 28; [Epub ahead of print]
Abstract（摘要）：Chronic kidney disease coexists with metabolic syndrome and this relationship may be apparent before overt manifestations of cardiovascular disease.
慢性肾病患者通常合并存在代谢综合症，这种情况在出现明显的心血管疾病之前更为显著
To investigate early stages of the natural history of associations between renal function and metabolic syndrome, we phenotyped 1572 young (mean age=18.4 years), apparently healthy men for metabolic risk factors and estimated their creatinine clearance based on the Cockcroft-Gault equation.
为了获得肾功能与代谢综合症之间早期关系的一手资料，我们分析归类了1572个看似健康但存在患代谢综合症危险因素的年轻人（平均年龄18.4岁）并以Cockcroft-Gault公式为基准评估了他们的肌肝清除率水平。
High metabolic risk (clustering of at least three metabolic risk factors) was revealed in 8.7% (137) of the subjects and was associated with a 6.9-fold increase in the odds of glomerular hyperfiltration (95% confidence interval (CI): 3.9-11.5) when compared to reference (from none to two metabolic risk factors).
在受试者中，代谢综合症高风险（至少有三个危险因素）的占8.7%（137个），其出现肾小球高滤过的机率比起对照组（即有一到两个危险因素）增加了6.9倍（95%的置信区间：3.9-11.5）。
Overweight, elevated blood pressure, and low high-density lipoprotein (HDL) cholesterol increased the multivariate-adjusted odds ratio of glomerular hyperfiltration to 6.6 (95% CI: 3.8-11.6), 1.8 (95% CI: 1.0-3.0), and 2.5 (95% CI: 1.5-4.3), respectively.
超体重，高血压，低、高密度脂蛋白、胆固醇的增高与肾小球高滤过的校正的多因素的风险比分别为6.6 (95% 置信区间: 3.8-11.6), 1.8 (95%置信区间: 1.0-3.0), 及 2.5 (95%置信区间: 1.5-4.3)。
Systolic and diastolic blood pressures clustered together with leptin in the factor analysis and this blood pressure-adiposity component correlated with estimated creatinine clearance (r=0.329, P<0.0001) and explained on its own 10.2% of the variance in the estimated renal function.
以血压和肥胖作为一个因素进行因素分析，发现血压-肥胖与评估所得的肌肝清除率有相关性(r=0.329, P<0.0001)，而且可以用来解释评估所得的肾功能的变化的10.2%
Our data reveal the silent epidemics of metabolic risk among young, apparently healthy men. Furthermore, the results indicate that high metabolic risk is associated with glomerular hyper filtration before overt manifestations of cardiovascular disease.
这些资料显示在看似健康的年轻人中存在潜在的患代谢综合症的风险，而且这些结果还表明在出现明显的心血管疾病之前，代谢综合症的高风险与肾小球的高滤过有关。
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作者:admin@医学,生命科学 2011-02-09 05:14
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