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【medical-news】果汁可能抵消抗组胺药物效用
Published date :
27 Aug 2008
MedWire News: People with allergic rhinitis should avoid drinking fruit juices at the same time as taking antihistamines, say researchers at the 236th National Meeting of the American Chemical Society, in Philadelphia, Pennsylvania, USA.
David Bailey, from the University of Western Ontario in London, Canada, and colleagues found that grapefruit and other common fruit juices such as orange and apple can significantly decrease the absorption of antihistamines.
Twenty years earlier, Bailey and team discovered that grapefruit juice increased the absorption of felodipine, an antihypertensive agent, potentially causing dangerous effects from excessive concentrations of the drug in the blood.
Since then, other researchers have identified many more medications that interact with grapefruit juice. As a result, some prescription medications now carry warning labels against drinking grapefruit juice while taking the drugs.
In the current study, Baily and team studied healthy volunteers who were asked to take the antihistamine fexofenadine while drinking grapefruit juice, water containing naringin - the substance in grapefruit juice that gives it a bitter taste - or water alone.
They found that participants who drank grapefruit juice or water with naringin absorbed around half as much antihistamine as participants who drank water alone.
The team also found that naringin appeared to block a key drug uptake transporter, OATP1A2, which has a role in transporting drugs from the small intestine into the bloodstream.
"This is just the tip of the iceberg," said Bailey. "I'm sure we'll find more and more drugs that are affected [in] this way."
He added that grapefruit juice may not be the only type of fruit juice that affects drug absorption, as orange and apple juices also contain naringin-like substances that may inhibit OATP1A2.
Speaking at the National Meeting of the American Chemical Society in Philadelphia, Pennsylvania, USA, Bailey concluded: "We discovered that grapefruit and these other fruit juices substantially decrease the oral absorption of certain drugs undergoing intestinal uptake transport."
He added: "The concern is loss of benefit of medications essential for the treatment of serious medical conditions."
Source :
Current Medicine Group 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Fruit juice may block benefits of antihistamines
果汁可能抵消抗组胺药的疗效
Published date :
发表日期：
27 Aug 2008
2008年8月27日
MedWire News: People with allergic rhinitis should avoid drinking fruit juices at the same time as taking antihistamines, say researchers at the 236th National Meeting of the American Chemical Society, in Philadelphia, Pennsylvania, USA.
医学在线新闻：在美国宾夕法尼亚州费城召开的第236届美国化学协会大会上，研究人员指出过敏性鼻炎患者应该避免在服用抗组胺药的同时喝果汁。
David Bailey, from the University of Western Ontario in London, Canada, and colleagues found that grapefruit and other common fruit juices such as orange and apple can significantly decrease the absorption of antihistamines.
David Bailey，来自伦敦的西安大略大学及加拿大研究人员发现，葡萄柚汁和其他常见果汁，如橙汁和苹果汁，能显著减少抗组胺药物的吸收。
Twenty years earlier, Bailey and team discovered that grapefruit juice increased the absorption of felodipine, an antihypertensive agent, potentially causing dangerous effects from excessive concentrations of the drug in the blood.
20年前，Bailey和其研究小组发现葡萄柚汁能增加抗高血压药物非洛地平的吸收，从而有引起血药浓度过高导致不良反应的潜在风险。
Since then, other researchers have identified many more medications that interact with grapefruit juice. As a result, some prescription medications now carry warning labels against drinking grapefruit juice while taking the drugs.
从那以后，其他研究人员证实葡萄柚汁可以和许多药物相互作用。结果，一些处方药在说明书中警告在服药时不要喝葡萄柚汁。
In the current study, Baily and team studied healthy volunteers who were asked to take the antihistamine fexofenadine while drinking grapefruit juice, water containing naringin - the substance in grapefruit juice that gives it a bitter taste - or water alone.
在这项研究中，bailey和其小组给健康志愿者服用抗组胺药非索非那定，分别用葡萄柚汁，加入柚皮素的水（葡萄柚中的一种物质，使其有苦味）和水服用。
They found that participants who drank grapefruit juice or water with naringin absorbed around half as much antihistamine as participants who drank water alone.
他们发现服用葡萄柚汁或加柚皮素水的人其血抗组胺药的浓度为用水服用者的一半。
The team also found that naringin appeared to block a key drug uptake transporter, OATP1A2, which has a role in transporting drugs from the small intestine into the bloodstream.
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作者:admin@医学,生命科学 2010-11-17 17:11
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