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【medical-news】种族和心理健康影响抗逆转录病毒
NEW YORK (Reuters Health) Apr 30 - Race and mental health diagnosis influence the risk of highly active antiretroviral therapy (HAART) failure, according to a report by researchers at Walter Reed Army Naval Medical Center, Washington, DC.
Despite the high prevalence of HIV infection among African Americans, race as a variable affecting the efficacy of HAART has rarely been examined, the investigators note in the in the April 1st issue of the Journal of Acquired Immune Deficiency Syndromes.
Dr. Joshua D. Hartzell and colleagues investigated the impact of race and other factors on the ability of patients infected with HIV to reach and maintain viral suppression with HAART.
After 12 months of HAART, only 63% of African Americans reached viral suppression, the authors report, compared with 92% of whites. However, the difference was no longer significant after 24 months of treatment.
Women fared better than men, the results indicate, and officers did better than enlisted patients.
At 24 months (but not at 12 months), 23% more patients without a mental health diagnosis reached viral suppression than patients with a mental health diagnosis.
In a multivariate analysis, viral suppression at 12 or 24 months was 8.5 times more likely in whites than in African Americans, 8.7 times more likely in patients without a mental health diagnosis, and 7 times more likely in women than in men. "This difference exists despite equal access to care for all beneficiaries," the investigators say.
"The current study augments the findings of other studies and suggests that discrepancies between races may not be simply secondary to access to care," the authors conclude. "Mental health continues to have a significant impact on HIV patients and potentially leads to virologic failure during HAART."
J Acquir Immune Defic Syndr 2007;44:411-416.
http://www.medscape.com/viewarticle/555875 本人认领此文. 如在48小时内未能提交译文, 其他战友自由认领. 译文470字.
Race, Mental Health Influence Antiretroviral Therapy Outcome
种族及心理健康影响抗逆转录病毒治疗效果
NEW YORK (Reuters Health) Apr 30 - Race and mental health diagnosis influence the risk of highly active antiretroviral therapy (HAART) failure, according to a report by researchers at Walter Reed Army Naval Medical Center, Washington, DC.
纽约（路透社健康新闻）4月30日报 — 华盛顿Walter Reed陆海军医疗中心的研究人员称，种族及心理健康影响高效抗逆转录病毒治疗（HAART）效果。
Despite the high prevalence of HIV infection among African Americans, race as a variable affecting the efficacy of HAART has rarely been examined, the investigators note in the in the April 1st issue of the Journal of Acquired Immune Deficiency Syndromes.
论文发表于《获得性免疫缺陷综合征》4月1日刊，文中研究人员称，尽管HIV感染在美国黑人中很普遍，但很少有研究探讨种族这一变量对HAART疗效的影响。
Dr. Joshua D. Hartzell and colleagues investigated the impact of race and other factors on the ability of patients infected with HIV to reach and maintain viral suppression with HAART.
Joshua D. Hartzel及其同事调查了HAART治疗后，种族及其它因素对HIV感染患者达到及保持病毒抑制的影响。
After 12 months of HAART, only 63% of African Americans reached viral suppression, the authors report, compared with 92% of whites. However, the difference was no longer significant after 24 months of treatment.
经过12月HAART治疗后，只有63%的黑人达到病毒抵制，而白人中这一数据为92%。但治疗24月后，无显著差异。
Women fared better than men, the results indicate, and officers did better than enlisted patients.
结果提示，就治疗结果而言，女性好于男性，军官优于士兵。
At 24 months (but not at 12 months), 23% more patients without a mental health diagnosis reached viral suppression than patients with a mental health diagnosis.
治疗24月（而非12月）后，无心理健康问题的患者比有问题的患者达到病毒抑制的比例高出23%。
In a multivariate analysis, viral suppression at 12 or 24 months was 8.5 times more likely in whites than in African Americans, 8.7 times more likely in patients without a mental health diagnosis, and 7 times more likely in women than in men. "This difference exists despite equal access to care for all beneficiaries 编译
种族及心理健康影响抗逆转录病毒治疗效果
纽约（路透社健康新闻）4月30日报 — 尽管HIV感染在美国黑人中很普遍，但很少有研究探讨种族这一变量对HAART疗效的影响。4月1日发表于《获得性免疫缺陷综合征》的一篇论文称，种族及心理健康影响高效抗逆转录病毒治疗（HAART）效果。
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作者:admin@医学,生命科学 2010-10-22 13:09
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