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【medical-news】氧水平成功的应用于判断肿瘤疗效
Measuring Cancer Therapy Success With Oxygen
ScienceDaily (Aug. 7, 2008) — Scientists at The Ohio State University (OSU) have identified a way to predict very early in the treatment process the outcome of radiation and chemotherapy for cervical cancer patients -- based on oxygen levels within the tumor.
The oxygenation of a tumor is critical for the success of cancer treatment. That's because the amount of oxygen in a cell is directly correlated with the ability of that cell to repair radiation damage. When the oxygen level is low, a state called hypoxia, the biological changes in tumor cells produced by radiation -- that will hopefully destroy the cells -- can be repaired, and tumor recurrence is more likely. But when oxygen is present, it reacts with free radical molecules to produce organic peroxide, which causes that damage to be "permanent and irreparable," says study head Jian Z. Wang, Ph.D., an Assistant Professor at OSU and the Director of the Radiation Response Modeling Program at the OSU James Cancer Hospital and Solove Research Institute. Inevitably, those well-oxygenated tumor cells die, tumors are less likely to return, and patient survival rates rise, says Wang.
In their study of 88 women with cervical cancer, Dr. Wang and his colleagues measured the level of hemoglobin, the oxygen-carrying molecule in blood, and measured blood supply to the tumor through magnetic resonance imaging (MRI) scans. Blood tests were conducted weekly beginning prior to treatment, and MRI scans were performed before radiation treatment, during radiation at 2-2.5 and 4-5 weeks, and 1-2 months after treatment. Cancer recurrence rates were tracked for up to 9 years. This study was supported by a NIH R01 grant led by the principal investigator Nina A. Mayr, M.D., Professor of Radiation Medicine at the OSU James Cancer Hospital and Solove Research Institute.
Measurements of tumor oxygenation just 2 weeks into treatment provided the best predictor of tumor control and disease-free survival. That early glimpse into the future can identify individuals at the greatest risk of having their cancer return, Mayr says, giving doctors the opportunity to adopt more aggressive therapies to improve the prognosis. Wang predicts that, with further testing, the technique also will prove useful for other types of cancer.
The research was described in the talk, "When the Oxygen Level Matters Mostly During Radiation Therapy of Cervical Cancer?" presented July 31, 2008 at the 50th annual meeting of the American Association of Physicists in Medicine. 本人已认领该篇文章，48小时候如果未交出请其他战友自动认领。 Measuring Cancer Therapy Success With Oxygen
用氧水平评价癌症治疗效果
ScienceDaily (Aug. 7, 2008) — Scientists at The Ohio State University (OSU) have identified a way to predict very early in the treatment process the outcome of radiation and chemotherapy for cervical cancer patients -- based on oxygen levels within the tumor.
每日科学（2008年8月7日）报道，来自于饿亥俄州大学（OSU）的科学家们发现了一种利用肿瘤内氧的水平来评价宫颈癌病人放疗和化疗的早期效果。
The oxygenation of a tumor is critical for the success of cancer treatment. That's because the amount of oxygen in a cell is directly correlated with the ability of that cell to repair radiation damage. When the oxygen level is low, a state called hypoxia, the biological changes in tumor cells produced by radiation -- that will hopefully destroy the cells -- can be repaired, and tumor recurrence is more likely. But when oxygen is present, it reacts with free radical molecules to produce organic peroxide, which causes that damage to be "permanent and irreparable," says study head Jian Z. Wang, Ph.D., an Assistant Professor at OSU and the Director of the Radiation Response Modeling Program at the OSU James Cancer Hospital and Solove Research Institute. Inevitably, those well-oxygenated tumor cells die, tumors are less likely to return, and patient survival rates rise, says Wang.
肿瘤的氧合作用是癌症治疗成功与否的关键。那是因为细胞内大量氧直接与肿瘤细胞对放射损伤造成的修复能力有关。当氧水平低，即所谓的低氧时，由放射造成的肿瘤细胞的生物学改变——即有希望破坏细胞，能够修复，导致肿瘤可能复发。但当氧存在时，它与游离基反映产生有机体超氧化物，这样就可导致这种损伤是“持续的和不可回复的。“来自于OSU James癌症医院和Solove研究院放疗反应模型工程主任王博士说道。理所当然，但那些富氧的肿瘤细胞死亡了，肿瘤复发的可能性较小，病人因而能存活更长时间。
In their study of 88 women with cervical cancer, Dr. Wang and his colleagues measured the level of hemoglobin, the oxygen-carrying molecule in blood, and measured blood supply to the tumor through magnetic resonance imaging (MRI) scans. Blood tests were conducted weekly beginning prior to treatment, and MRI scans were performed before radiation treatment, during radiation at 2-2.5 and 4-5 weeks, and 1-2 months after treatment. Cancer recurrence rates were tracked for up to 9 years. This study was supported by a NIH R01 grant led by the principal investigator Nina A. Mayr, M.D., Professor of Radiation Medicine at the OSU James Cancer Hospital and Solove Research Institute
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作者:admin@医学,生命科学 2011-03-25 15:22
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