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【medical-news】LDL-c水平与癌症风险
LDL cholesterol level associated with cancer risk
CMAJ 2008; 179: 403-404, 427-437
MedWire News: Researchers have demonstrated a V-shaped association between low-density lipoprotein (LDL) cholesterol and cancer incidence in patients with Type 2 diabetes mellitus.
Juliana Chan and colleagues from the Chinese University of Hong Kong say that several studies have "demonstrated an inverse relation between serum total cholesterol and cancer incidence and mortality in the general population."
However, "few studies have investigated this relation among patients with Type 2 diabetes mellitus," they add.
Chan and team recruited a group of 6107 patients with Type 2 diabetes who were cancer-free at baseline. The researchers measured serum lipids and anthropometric measurements at enrolment.
The participants were then followed up for an average of 4.9 years, during which 270 individuals developed cancer, giving an incidence rate of 4.4%.
The authors then assessed associations between LDL cholesterol concentration and cancer incidence.
As published in the Canadian Medical Association Journal, Chan et al found a V-shaped association between LDL cholesterol level and cancer incidence in participants not receiving statin therapy.
Patients with a LDL cholesterol concentration of 2.80-3.79 mmol/l (108.36-147.06 mg/dl) had the lowest risk for cancer, while those who had LDL cholesterol below 2.80 mmol/l (108.36 mg/dl), and those with levels of 3.80 mmol/l (147.06 mg/dl) or above were at higher risk.
Compared with the intermediate LDL group, hazard ratios for cancer in the low and high LDL groups were 1.74 and 1.87, respectively.
The researchers note that the associations persisted after adjustment for potential confounders and exclusion of individuals with less than 2.5 years of follow-up.
In an accompanying editorial, Eric Ding and Frank Hu from Harvard University in Boston, Massachusetts, USA cautioned: "A V-shaped association between LDL cholesterol and cancer risk suggests that multiple mechanisms are involved. LDL cholesterol is unlikely the sole or direct causal factor."
They added that "further investigations are required about the implications of cholesterol-lowering drug therapy on cancer risk and the ability of LDL cholesterol to predict the development of specific cancers in the general population as well as in patients with diabetes."
注：最近对降低LDL-c水平与升高癌症发生的讨论十分热烈，于是本小虫google后发现了一比较新的研究，还是中国的哦（香港），希望对大家理解LDL-c与癌症发生间的关系有所帮助 本人已认领本文翻译48小时未提交请其他战友继续认领 LDL cholesterol level associated with cancer risk
CMAJ 2008; 179: 403-404, 427-437
MedWire News: Researchers have demonstrated a V-shaped association between low-density lipoprotein (LDL) cholesterol and cancer incidence in patients with Type 2 diabetes mellitus.
研究人员已经证实在患2型糖尿病的病人中，低密度脂蛋白（LDL）胆固醇与癌症的发病率之间存在着V型的联系。
Juliana Chan and colleagues from the Chinese University of Hong Kong say that several studies have "demonstrated an inverse relation between serum total cholesterol and cancer incidence and mortality in the general population."
香港中文大学的Juliana Chan和他的同事们称，几项研究已经证明在一般人群中，血浆总胆固醇量和癌症的发病率之间存在这相反的关系。
However, "few studies have investigated this relation among patients with Type 2 diabetes mellitus," they add.
然而，他们补充说：“还几乎没有对2型糖尿病人这种关系的研究。
Chan and team recruited a group of 6107 patients with Type 2 diabetes who were cancer-free at baseline. 研究人员已经证实在患2型糖尿病的病人中，低密度脂蛋白（LDL）胆固醇与癌症的发病率之间存在着V型的联系。香港中文大学的Juliana Chan和他的同事们称，几项研究已经证明在一般人群中，血浆总胆固醇量和癌症的发病率之间存在这相反的关系。然而，他们补充说：“还几乎没有对2型糖尿病人这种关系的研究。Chan和他的研究小组招募了一组6107位未患癌症的2型糖尿病人。在登记时研究人员给病人测量了血脂并做了人体测量。接下来研究人员对受试者做了平均为4.9年的随访，在随访期间有270人患了癌症，癌症的发病率为4.4%。接下来作者对LDL胆固醇浓度与癌症的发病率之间的关系进行了评估。正如发表在《加拿大医学会杂志》上的结果一样，Chan等人发现在未使用他汀药物治疗的受试者中，LDL胆固醇水平与癌症的发病率之间存在着V型的关系。LDL胆固醇浓度在2.80-3.79 mmol/l (108.36-147.06 mg/dl)之间的病人患癌症的风险最低，LDL胆固醇浓度低于2.80 mmol/l (108.36 mg/dl)，以及浓度达到或高于3.80 mmol/l (147.06 mg/dl)的病人患癌症的风险要高一些。同中等浓度LDL的组相比，高LDL组与低LDL组患癌症的危害比分别为1.74和1.87. 研究人员强调，调整了潜在的混杂因素并排除了随访时间低于2.5年的个体以后，这种联系依然存在。在随附的评论中，美国马萨诸塞波士顿哈佛大学的Eric Ding和Frank Hu告诫说：“LDL胆固醇与癌症发病率之间存在的V型联系说明，牵涉的机制是多方面的。LDL胆固醇不是唯一或者说是直接的病因。” 他们补充道：“还需要进一步的研究一般人群和糖尿病患者中，癌症危险性的降胆固醇药物疗法与LDL胆固醇预防特定癌症发展功能之间的联系。” cancer-free at baseline.
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作者:admin@医学,生命科学 2011-02-06 17:14
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