主页 > 医学动态 >
【medical-news】深部脑刺激术可减少抗震颤麻痹药
By David Douglas
NEW YORK (Reuters Health) Feb 09 - Subthalamic nucleus (STN) deep brain stimulation modulates afferent inhibition in Parkinson's disease and also appears to offset untoward side effects of medication, Canadian and Swedish researchers report in the January 30th issue of Neurology.
"Although STN stimulation is increasingly being used to treat Parkinson's disease, how it works is not fully understood," senior investigator Dr. Robert Chen told Reuters Health. "Our findings suggest STN stimulation may have a direct effect of reducing the side effects of Parkinson medications such as dyskinesia, and not just through reduction in the dosages of medications."
Dr. Chen of the University of Toronto and colleagues came to this conclusion after they studied the effects of STN stimulation in 7 Parkinson's patients and age-matched controls.
The patients were studied in an off-medication session followed by an on-medication session. The stimulator was switched on or off in random order in each session.
The researchers note that previous studies suggested that reduced short latency afferent inhibition in Parkinson's disease reflects the adverse effect of dopaminergic medications and reduced latency afferent inhibition may be related to nondopaminergic manifestations of the disease.
In the on-medication session, the team found that short latency afferent inhibition was reduced in the stimulator off condition and was restored by STN stimulation. Latency afferent inhibition was partially normalized by STN stimulation in the medication-on condition.
"It is known that symptoms that respond to dopaminergic drugs... are improved by STN stimulation," concluded Dr. Chen. "Our study suggests that symptoms that do not respond to dopaminergic medications may also be improved by STN stimulation."
Neurology 2007;68:356-363.
http://www.medscape.com/viewarticle/551993 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Brain Stimulation Limits Side Effects of Parkinson's Drugs
By David Douglas
NEW YORK (Reuters Health) Feb 09 - Subthalamic nucleus (STN) deep brain stimulation modulates afferent inhibition in Parkinson's disease and also appears to offset untoward side effects of medication, Canadian and Swedish researchers report in the January 30th issue of Neurology.
纽约（路透社健康栏目）2月9日消息，《神经学杂志》1月30日刊报道，加拿大和瑞典的研究者发现，丘脑底核深部脑刺激调节帕金森(氏)病的传入性抑制，也可以减少药物疗法的副作用。
"Although STN stimulation is increasingly being used to treat Parkinson's disease, how it works is not fully understood," senior investigator Dr. Robert Chen told Reuters Health. "Our findings suggest STN stimulation may have a direct effect of reducing the side effects of Parkinson medications such as dyskinesia, and not just through reduction in the dosages of medications."
尽管丘脑底核刺激越来越多的被用在治疗帕金森(氏)病，但是其作用机制尚还不完全明白。资深研究者Robert Chen博士告诉路透社健康栏目记者，我们的研究表明丘脑底核刺激有直接减少帕金森(氏)病药物疗法的副作用如运动障碍的效果，而且不是通过减少药物的剂量降低副作用。
Dr. Chen of the University of Toronto and colleagues came to this conclusion after they studied the effects of STN stimulation in 7 Parkinson's patients and age-matched controls.
多伦多大学的Chen博士及其同仁，研究了7名年龄相仿的帕金森(氏)病患者丘脑底核刺激的治疗作用而得出这个结论。
The patients were studied in an off-medication session followed by an on-medication session. The stimulator was switched on or off in random order in each session.
接受研究的病人分为用药期和停药期，按照随机顺序给每期刺激物或移开刺激物。
The researchers note that previous studies suggested that reduced short latency afferent inhibition in Parkinson's disease reflects the adverse effect of dopaminergic medications and reduced latency afferent inhibition may be related to nondopaminergic manifestations of the disease.
研究者注意到，过去的研究表明，帕金森(氏)病人短潜伏期的传入抑制减少是多巴胺能药物疗法的不良作用，潜在传入抑制的减少可能与帕金森(氏)病的非多巴胺能现象有关。
In the on-medication session, the team found that short latency afferent inhibition was reduced in the stimulator off condition and was restored by STN stimulation. Latency afferent inhibition was partially normalized by STN stimulation in the medication-on condition.
在给药期间，研究者发现，短潜伏期的传入抑制在移除刺激物时减少，而经过丘脑底核刺激恢复。潜在的传入抑制在给药条件下通过丘脑底核刺激部分恢复正常。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-01 05:14
医学,生命科学网