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【bio-news】梭菌属细菌促发小鼠结肠调节性T细胞
文字说明: 小鼠结肠的梭菌属细菌种刺激肠上皮细胞分泌 TGF-b，造成Foxp3表达的T细胞的累积以及IL -10在结肠的产生，这有助于抑制炎症和过敏性反应。
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One bacterium brings on the T cells
How exactly do the countless microbes that call our bodies "home" help us to maintain healthy immune systems? A new study with mice has shown that specific bacteria of the genus Clostridium promote the generation of regulatory T cells, or Treg cells, in the mouse colon—a discovery that suggests new therapeutic approaches to allergies and autoimmunity. Koji Atarashi and colleagues first eliminated all the bacteria from the colons of mice and found that populations of colonic Treg cells plummeted. By dosing those bacteria-free mice with a certain mix of Clostridium strains, the researchers observed a return of those Treg cells to the colon. The researchers also found that feeding wild-type mice (with all their commensal bacteria intact) the Clostridium bacteria produced elevated levels of Treg cells in the mice and helped the rodents to ward off autoimmune colitis and other allergies. These data highlight how these particular Clostridium bacteria help to regulate specific immune cell populations, and in the future the findings might even be used to improve treatment for certain autoimmune diseases.
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Article #22: "Induction of colonic regulatory T cells by indigenous Clostridium species," by K. Atarashi; T. Tanoue; T. Taniguchi; K. Honda; Y. Momose; K. Itoh at The University of Tokyo in Tokyo, Japan; T. Shima; A. Imaoka; Y. Umesaki at Yakult Central Institute for Microbiological Research in Tokyo, Japan; T. Kuwahara at The University of Tokushima Graduate School in Tokushima, Japan; K. Takeda at University of California, Los Angeles in Los Angeles, CA; S. Yamasaki; T. Saito; S. Hori at RIKEN Research Center for Allergy and Immunology in Yokohama, Japan; Y. Ohba at Graduate School of Medicine, Hokkaido University in Sapporo, Japan; I.I. Ivanov at Columbia University Medical Center in New York, NY; K. Honda at Japan Science and Technology Agency in Saitama, Japan. 全文
Induction of colonic regulatory T cells by indigenous Clostridium species
science.1198469.full.pdf (1285.9k) 在线查看 谢谢分享！ 谢谢分享 一种促发T细胞的细菌_研究动态_研究动态_突发公共卫生事件咨询...一项在小鼠身上所做的新的研究显示,梭菌属的特别细菌会促进小鼠结肠中的调节性T细胞... 将来,这些发现甚至可被用来改善对某些自身免疫性疾病的治疗.eph.org.cn/...asp?NewsID=24971-2010-12-24-快照-促发T细胞的细菌_研究动态_研究动态_突发公共卫生事件咨询..." 12月24日《科学》杂志精选_科技频道_凤凰网一项在小鼠身上所做的新的研究显示,梭菌属的特别细菌会促进小鼠结肠中的调节性T细胞... 左旋咖啡狂减冬膘30斤 前列腺炎--可轻松自愈 腰椎病--在家轻松治疗 牛皮顽癣--新药抗复...tech.ifeng.com/...3292_0.shtml-2010-12-31-快照-消化系统疾病鉴别诊断与治疗学图书购买 - 异侠图书搜索[前言]在疾病的诊治流程中,诊断是治疗的依据,即所谓“对症下药”,如要得到正确的诊断,... 疗第78章难辨梭菌感染鉴别诊断与治疗第79章幽门螺杆菌感染鉴别诊断与治疗第80章致...lib.yixia.net/388/1307027/-2009-08-05-快照-疾病鉴别诊断与治疗学图书购买 - 异侠图书搜索"[标签:content2]
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作者:admin@医学,生命科学 2011-01-04 12:22
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