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【medical-news】尿血管紧张素原作为肾内血管紧张
In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in deterioration of renal function, but it is difficult to measure it. For assessment of the potential of urinary angiotensinogen as a marker of intrarenal AngII activity, the correlation of plasma and urinary renin-angiotensin system components, including angiotensinogen, with deterioration of renal function was investigated in 80 patients who had CKD and were not treated with AngII blocking agents. Changes that were induced by 14 d of losartan treatment (25 mg/d) were also measured in 28 patients. Angiotensinogen was measured by RIA of AngI after incubation with renin. Urinary angiotensinogen levels were greater in patients with low estimated GFR and elevated urinary protein and type IV collagen and correlated with renal AngII and type I collagen immunostaining intensities. The risk for deterioration of renal function (i.e., estimated GFR decline of >2.5 ml/min per yr) during a mean follow-up period of 23 mo (maximum 43 mo) was associated with urinary angiotensinogen of >3.0 nmol AngI equivalent per 1 g of urinary creatinine (AngI Eq/g Cre) at enrollment (hazard ratio 3.52). The event-free survival for deterioration of renal function was better in patients with urinary angiotensinogen <3.0 nmol AngI Eq/g Cre than those >3.0 nmol AngI Eq/g Cre. Losartan reduced urinary and plasma angiotensinogen, urinary protein and type IV collagen, and systolic BP, despite concomitant increases in plasma renin and AngII. These data suggest that urinary angiotensinogen is a potentially suitable marker of intrarenal AngII activity associated with increased risk for deterioration of renal function in patients with CKD. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Urinary Angiotensinogen as a Marker of Intrarenal Angiotensin II Activity Associated with Deterioration of Renal Function in Patients with Chronic Kidney Disease作为肾内血管紧张素II活力标志的尿血管紧张素原与慢性肾病病人肾功能加重相关
In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in deterioration of renal function, but it is difficult to measure it.在慢性肾病时,增高的肾内血管紧张素II (AngII) 参与了肾功能病变加重过程,但很难去评估它. For assessment of the potential of urinary angiotensinogen as a marker of intrarenal AngII activity, the correlation of plasma and urinary renin-angiotensin system components, including angiotensinogen, with deterioration of renal function was investigated in 80 patients who had CKD and were not treated with AngII blocking agents. 为了评价尿血管紧张素原作为肾内血管紧张素II (AngII)活力标志的可能性,我们来观察80个未用血管紧张素II (AngII)治疗的慢性肾病病人,血和尿肾素血管紧张素系统成分包括血管紧张素原和肾功能加重的相关度.Changes that were induced by 14 d of losartan treatment (25 mg/d) were also measured in 28 patients. 经过14天的氯沙坦治疗,这种相关性在28 个病人中检测到.Angiotensinogen was measured by RIA of AngI after incubation with renin.在有肾素存在,血管紧张素原可通过放射免疫分析血管紧张素I 来检测. Urinary angiotensinogen levels were greater in patients with low estimated GFR and elevated urinary protein and type IV collagen and correlated with renal AngII and type I collagen immunostaining intensities. 有低肾小球滤过率GFR和高尿蛋白.IV 型胶原的病人尿血管紧张素原水平较高,和肾内AngII I 型胶原免疫染色程度有关.The risk for deterioration of renal function (i.e., estimated GFR decline of >2.5 ml/min per yr) during a mean follow-up period of 23 mo (maximum 43 mo) was associated with urinary angiotensinogen of >3.0 nmol AngI equivalent per 1 g of urinary creatinine (AngI Eq/g Cre) at enrollment (hazard ratio 3.52).在平均23 个月(最长43 个月)的随访期,肾功能加重的危险度(GFR下降为>2.5 ml/min per yr)与尿血管紧张素原(通过 AngI 间接反映,>3.0 nmol [AngI Eq/g Cre等同1克的尿肌酐])相关(危险比3.52).The event-free survival for deterioration of renal function was better in patients with urinary angiotensinogen <3.0 nmol AngI Eq/g Cre than those >3.0 nmol AngI Eq/g Cre.肾功能加重好转率在尿血管紧张素原小于3.0 nmol AngI Eq/g Cre 比大于3.0 nmol AngI Eq/g Cre的病人更高. Losartan reduced urinary and plasma angiotensinogen, urinary protein and type IV collagen, and systolic BP, despite concomitant increases in plasma renin and AngII. 氯沙坦可以减少尿和血浆的血管紧张素原,尿蛋白,IV 型胶原,收缩压,尽管伴随有血浆肾素和血管紧张素II(AngII.)的增加.These data suggest that urinary angiotensinogen is a potentially suitable marker of intrarenal AngII activity associated with increased risk for deterioration of renal function in patients with CKD. 这些数据说明:尿血管紧张素原是潜在的适宜的肾内血管紧张素II活力标志,与慢性肾病肾功能加重相关. 有点乱...可改为一段英文（回车）一段中文（回车）贴出。另，可给段落编号以便他人浏览、纠错... 作为肾内血管紧张素II活力标志的尿血管紧张素原与慢性肾病病人肾功能加重相关
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作者:admin@医学,生命科学 2010-12-08 05:11
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