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【medical-news】呼吸道病毒感染增强儿童继后发生
NEW YORK (Reuters Health) Aug 28 - Respiratory viral infections are associated with an increased risk of subsequent seasonal invasive pneumococcal disease in children, researchers report in the August issue of Pediatrics.
Dr. Krow Ampofo of the University of Utah, Salt Lake City and colleagues note that since the introduction of heptavalent pneumococcal conjugate vaccine (PCV-7) there has been a substantial reduction in invasive pneumococcal disease in young children but an increase in non-PCV7 serotypes in children.
To investigate possible correlations between invasive pneumococcal disease in children and circulating respiratory viruses, the researchers reviewed data collected at two healthcare centers in Utah during the winters of 2001-2007. Overall, more than 11,000 patient samples were collected that were positive for a respiratory virus, including respiratory syncytial virus (RSV) (61.3%), influenza (16.4%), parainfluenza (12.8%) and adenovirus (7.2%). In the last 5 months of the study period, samples were also tested for human metapneumovirus, which accounted for 13% of all positive samples during that period.
Over the whole study period, 435 children with invasive pneumococcal disease and 203 with culture-confirmed disease were hospitalized.
The authors observed correlations between invasive pneumococcal disease and influenza virus, human metapneumovirus, and RSV activity. The correlation with invasive pneumococcal disease was strong at 2 weeks after activity of influenza virus and human metapneumovirus and for up to 4 weeks after RSV activity.
Pneumonia, say the researchers, was the most common clinical disease associated with culture-confirmed invasive pneumococcal disease and this was mostly attributable to serotypes 1, 19A, 3, and 7F.
The investigators stress that "the temporal association does not prove a causal relationship." Also, they point out, the epidemiological features of invasive pneumococcal disease in children in Utah are not representative of the United States in general.
"Despite the important impact of PCV-7, S. pneumoniae is proving to be an adaptable foe and may continue to evolve in the presence of newer conjugate vaccines," the researchers conclude. "We speculate that prevention of influenza virus, RSV, and human metapneumovirus infections may ultimately prove to be an important strategy to control pneumococcal disease in the post-PCV-7 era."
Pediatrics 2008;122:229-237. 我试着翻译一下。
Respiratory Viral Infections Tied to Pediatric Pneumococcal Disease
呼吸道病毒与儿童肺炎球菌感染相联系
NEW YORK (Reuters Health) Aug 28 - Respiratory viral infections are associated with an increased risk of subsequent seasonal invasive pneumococcal disease in children, researchers report in the August issue of Pediatrics.
纽约（路透社健康）8/28－研究人员在儿科杂志8月期报道认为，呼吸道病毒感染与增加儿童继发性季节性性侵袭性肺炎球菌疾病的风险相关联。
Dr. Krow Ampofo of the University of Utah, Salt Lake City and colleagues note that since the introduction of heptavalent pneumococcal conjugate vaccine (PCV-7) there has been a substantial reduction in invasive pneumococcal disease in young children but an increase in non-PCV7 serotypes in children.
盐城湖市犹他大学的Dr.Krow Ampofo 和他的同事的短文提示七价的肺炎球菌联合疫苗的介入，相当大程度上减少了儿童侵袭性肺炎球菌疾病的发生，但是增加了非七价肺炎球菌联合疫苗血清型肺炎球菌感染。
To investigate possible correlations between invasive pneumococcal disease in children and circulating respiratory viruses, the researchers reviewed data collected at two healthcare centers in Utah during the winters of 2001-2007. Overall, more than 11,000 patient samples were collected that were positive for a respiratory virus, including respiratory syncytial virus (RSV) (61.3%), influenza (16.4%), parainfluenza (12.8%) and adenovirus (7.2%). In the last 5 months of the study period, samples were also tested for human metapneumovirus, which accounted for 13% of all positive samples during that period.
为观察儿童侵袭性肺炎球菌疾病与呼吸道流通病毒之间存在的可能关系，研究人员回顾了收集来自2001－2007年犹他州两家卫生护理中心的数据。收集总数超过11，000患者样本，这些样本的呼吸道病毒均为阳性，包括呼吸道合胞病毒（61.3％），流感病毒（16.4％），副流感病毒（12.8％）和腺病毒（7.2％）。在研究进行后期的5个月里，标本还被用来检测人偏肺病毒的存在，其占在此期间阳性标本中约13％的比例。
Over the whole study period, 435 children with invasive pneumococcal disease and 203 with culture-confirmed disease were hospitalized.
在整个的研究阶段，435名患侵袭性肺炎球菌疾病的患儿以及203名培养证实感染的患儿住院治疗。
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作者:admin@医学,生命科学 2010-10-24 05:11
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