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【medical-news】为什么酒精会增加患乳腺癌的风险
为什么酒精会增加患乳腺癌的风险
Last Updated: 2007-04-30 14:00:09 -0400 (Reuters Health)
By Megan Rauscher
NEW YORK (Reuters Health) - A study in mice shows that moderate alcohol consumption stimulates the growth and progression of breast cancer by fueling the development of new blood vessels -- a process called "angiogenesis." It does this by boosting expression of a key growth factor known as vascular endothelial growth factor or VEGF.
对小鼠的研究显示，适量酒精摄入能推进新生血管的的形成，即所谓的“血管生成”来刺激乳腺癌的生长和进展。该作用是通过血管内皮生长因子（VEGF）的过量表达来实现的。
Drinking alcohol -- even moderate amounts - is a well-established risk factor for breast cancer in women. A recent study found that 60 percent of breast cancer cases in women worldwide were attributable to alcohol consumption. But the mechanism of alcohol-induced breast cancer are poorly understood.
饮酒——就算是适量——对女性来说是患乳腺癌的危险因素，这已是不争的事实。最近的研究发现世界上60%的乳腺病例可归咎于饮酒。但是酒精致乳腺癌的机理尚不清楚。
Dr. Jian-Wei Gu and colleagues from the University of Mississippi Medical Center in Jackson examined the effects of alcohol on tumor growth and progression of breast cancer in mice.
来自位于杰克逊的密西西比医学中心大学的谷建伟（音译）医生和他的同事们研究了酒精对小鼠体内乳腺癌生长和进展的作用。
For 4 weeks, 6-week old female mice consumed regular drinking water or water containing 1 percent alcohol, which is equivalent to about 2 to 4 drinks in humans. In week 2, the animals were inoculated with mouse breast cancer cells.
选择6周龄的雌性小鼠，给予规律饮水或含有1%酒精的水，相当于人2到4口酒，为期4周，在第2周时接种小鼠乳腺癌细胞。
"We found after about 4 weeks that breast tumor size almost doubled in mice that drank alcohol compared to control mice given plain water," Gu noted in a telephone interview with Reuters Health. Moderate alcohol intake also caused a noteworthy increase in tumor blood vessels compared with no alcohol intake.
“我们发现4周后，那些饮酒的小鼠体内的乳腺肿瘤体积差不多是饮水对照组的2倍，”谷在和路透社的访谈中说。适量的酒精摄入和无酒精摄入的对照组相比还有明显的肿瘤血管增生。
The team also observed a significant increase in VEGF levels in the tumors of mice consuming alcohol compared to the tumors of control mice.
研究团队还在饮酒小鼠肿瘤内发现明显高于对照水平的VEGF。
"VEGF can promote the formation of new blood vessels," Gu said. "This suggests that alcohol can induce tumor angiogenesis."
“VEGF能促进新血管的形成，”谷说，“这提示酒精能引起肿瘤血管生成。”
He presented the research at the American Physiological Society's annual meeting, part of Experimental Biology 2007, underway in Washington DC.
作为2007实验生物学的一个部分，在华盛顿DC举办的美国生理学协会年会上，他展示了他的研究成果。
编译 ：
为什么酒精会增加患乳腺癌的风险
对小鼠的研究显示，适量酒精摄入能推进新生血管的的形成，即所谓的“血管生成”来刺激乳腺癌的生长和进展。该作用是通过血管内皮生长因子（VEGF）的过量表达来实现的。
饮酒——就算是适量——对女性来说是患乳腺癌的危险因素，这已是不争的事实。最近的研究发现世界上60%的乳腺病例可归咎于饮酒。但是酒精致乳腺癌的机理尚不清楚。
来自位于杰克逊的密西西比医学中心大学的谷建伟（音译）医生和他的同事们研究了酒精对小鼠体内乳腺癌生长和进展的作用。
选择6周龄的雌性小鼠，给予规律饮水或含有1%酒精的水，相当于人2到4口酒，为期4周，在第2周时接种小鼠乳腺癌细胞。
“我们发现4周后，那些饮酒的小鼠体内的乳腺肿瘤体积差不多是饮水对照组的2倍，”谷在和路透社的访谈中说。适量的酒精摄入和无酒精摄入的对照组相比还有明显的肿瘤血管增生。
研究团队还在饮酒小鼠肿瘤内发现明显高于对照水平的VEGF。
“VEGF能促进新血管的形成，”谷说，“这提示酒精能引起肿瘤血管生成。”
作为2007实验生物学的一个部分，在华盛顿DC举办的美国生理学协会年会上，他展示了他的研究成果。
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作者:admin@医学,生命科学 2010-10-14 05:11
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