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【技术产业】智能材料有助于再生骨组织
Intelligent Materials To Regenerate Bone Tissue
Article Date: 02 Apr 2007 - 0:00 PDT
More than half a million people in the European Union and a million in the United States suffer from disorders in or serious defects of some part of their bone structure. Operations involving grafts or implants, required to mitigate the damage, depend decisively on the materials used.
The European Nanobiocom project, led by INASMET-Tecnalia with the help of others, is working on the regeneration and repair of bone tissue. Seven other bodies, leaders in innovation within this specialism, are also taking part in the project. The goal is to come up with a substitute for bone tissue that can put the bone right and regenerate in such a way that it carries out similar functions as in its natural state. From Spain the Institute of Biomechanics of Valencia and Progénika Biopharma S.A. are also participating.
In the case of substantial deterioration of the bone, it may be necessary for the implant to provide both functional and physiological properties of the damaged item. Given this hypothesis, the bone implants have to comply with a series of requisites capable of contributing to a reconstruction of the deteriorated bone tissue in the most efficient and least discomfiting manner, without any serious repercussion. Another exigency involves the carrying out of the mechanical functions of the damaged bone while the desired regeneration takes place.
The solutions have to be capable, moreover, of remedying particularly serious damage, such as those due to congenital deficiencies, degenerative illnesses, cancerous disorders and other damage caused by accidents. The implants required for this type of solutions are more complex and sophisticated than the small implants known to date.
The Nanobiocom project aims at developing a support matrix (scaffold) of a compound material that is 'intelligent', proactive, and capable of repairing and regenerating bone tissue. To this end, it has to be bioactive, capable of acting on the tissue-generating system and its corresponding genes, as well as respond appropriately to the physiological and biological changes, both internal and external, of that system.
Also necessary are size and shape characteristics, as well as mechanical functions appropriate to healthy bones.
The specific tasks of the project focus on putting the finishing touches to the intelligent material, based on nanoparticles and of a biodegradable nature. Also to be developed is the cell culture in three dimensions, as well as ensuring the biocompatibility of the material. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Intelligent Materials To Regenerate Bone Tissue
智能材料有助于骨组织再生
Article Date: 02 Apr 2007 - 0:00 PDT
More than half a million people in the European Union and a million in the United States suffer from disorders in or serious defects of some part of their bone structure. Operations involving grafts or implants, required to mitigate the damage, depend decisively on the materials used.
欧洲逾五十万人、美国近一百万人正遭受骨结构紊乱或严重骨缺失。减轻损害的手术包括移植术和埋植术，都极其依赖其所使用的材料。
The European Nanobiocom project, led by INASMET-Tecnalia with the help of others, is working on the regeneration and repair of bone tissue. Seven other bodies, leaders in innovation within this specialism, are also taking part in the project. The goal is to come up with a substitute for bone tissue that can put the bone right and regenerate in such a way that it carries out similar functions as in its natural state. From Spain the Institute of Biomechanics of Valencia and Progénika Biopharma S.A. are also participating.
由INASMET-Tecnalia率领的，在其它团队帮助下的欧洲Nanobiocom计划正致力于骨组织的再生和修复。其他7个团队，也是这个革新领域的领导者，都参与了这项计划。目标是达到骨组织替代物的要求——可校正骨骼以及促进骨再生，与自然状态下组织的功能相似。来自西班牙巴伦西亚的生物力学研究所和南美的Progénika Biopharma也参与了这项研究。
In the case of substantial deterioration of the bone, it may be necessary for the implant to provide both functional and physiological properties of the damaged item. Given this hypothesis, the bone implants have to comply with a series of requisites capable of contributing to a reconstruction of the deteriorated bone tissue in the most efficient and least discomfiting manner, without any serious repercussion. Another exigency involves the carrying out of the mechanical functions of the damaged bone while the desired regeneration takes place.
为了替代受损的骨组织，需要植入体能具有受损部位的功能和生理特性。鉴于这一假设，骨植入体必须能以最有效的方式、最低的不适感来帮助受损骨组织的重建，并且无严重的副反应。另一亟需解决的是当所期望的骨再生发生时，它能执行受损骨组织的机械功能。
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作者:admin@医学,生命科学 2010-12-19 05:11
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