主页 > 生命科学 >
【medical-news】高水平的CRP预测腹透相关性腹膜炎
N Y Zalunardo1, C L Rose1, I W Y Ma2 and P Altmann3
We examined the association between C-reactive protein (CRP) and short- and long-term adverse outcomes in peritoneal dialysis (PD)-associated peritonitis. Serum CRP levels were measured at baseline and 3 weeks after initiation of treatment in 209 patients with an incident episode of peritonitis between 1 January 1999 and 31 March 2005. Patients were followed until 31 May 2005. Short-term adverse outcomes included switch to hemodialysis, death, persistent infection beyond planned therapy duration, and relapse; long-term adverse outcomes included a subsequent peritonitis event or death. After adjustment for age, gender, diabetes, duration of renal replacement therapy and causative organism, patients with higher CRP levels at diagnosis had a greater odds of an adverse short-term outcome (odds ratio 1.57 (95% confidence interval (CI): 0.61–4.02), 2.73 (95% CI: 1.09–6.87), and 3.38 (95% CI: 1.36–8.42) in the second, third, and highest quartiles). In patients who met criteria for resolution of peritonitis 3 weeks after diagnosis, those with higher CRP levels had a greater risk of a long-term adverse outcome (hazard ratio 1.79 (95% CI: 1.05–3.07)). In conclusion, higher levels of CRP are independently associated with adverse outcomes in PD-associated peritonitis. Serial measurement of this marker during the course of peritonitis may facilitate earlier identification of individuals at greater risk of complications. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Serum CRP levels were measured at baseline and 3 weeks after initiation of treatment in 209 patients with an incident episode of peritonitis between 1 January 1999 and 31 March 2005. Patients were followed until 31 May 2005.
本研究募集了在1999年1月1日至2005年3月31日之间进行腹透且出现腹膜炎并发症的209名患者，检测了基线水平及治疗三周后的血浆CRP。病人一直随访到2005年5月31日。
Short-term adverse outcomes included switch to hemodialysis, death, persistent infection beyond planned therapy duration, and relapse; long-term adverse outcomes included a subsequent peritonitis event or death. 短期的不良反应包括转入血透、死亡、超出计划治疗期的持续性感染以及感染复发，长期的不良反应包括随之发生的腹膜炎或者死亡。
After adjustment for age, gender, diabetes, duration of renal replacement therapy and causative organism, patients with higher CRP levels at diagnosis had a greater odds of an adverse short-term outcome (odds ratio 1.57 (95% confidence interval (CI): 0.61–4.02), 2.73 (95% CI: 1.09–6.87), and 3.38 (95% CI: 1.36–8.42) in the second, third, and highest quartiles). 经过对组间年龄、性别、糖尿病病史、肾脏代替治疗时程和病源器官等因素的平衡，具有高水平CRP的患者在诊断腹膜炎后，发生短期不良反应的可能性更大（二、三、四分位OR值分别为1.57, 2.73, 3.38 95%可信区间分别为为0.61–4.02, 1.09–6.87, 1.36–8.42,并且四分位数最高。）
In patients who met criteria for resolution of peritonitis 3 weeks after diagnosis, those with higher CRP levels had a greater risk of a long-term adverse outcome (hazard ratio 1.79 (95% CI: 1.05–3.07)).在符合腹膜炎标准并在诊断后经三周治疗的患者中，那些具有高水平CRP的患者长期不良反应的风险更大（风险率为1.79，95%可信区间CI 1.05–3.07）
In conclusion, higher levels of CRP are independently associated with adverse outcomes in PD-associated peritonitis. Serial measurement of this marker during the course of peritonitis may facilitate earlier identification of individuals at greater risk of complications.总结，高水平CRP是腹透相关性腹膜炎的不良反应的独立相关因素。在腹透相关性腹膜炎期间对这一标志物的检测可能有助于更早期的识别有更高风险的并发症
本研究募集了在1999年1月1日至2005年3月31日之间进行腹透且出现腹膜炎并发症的209名患者，检测了基线水平及治疗三周后的血浆CRP。病人一直随访到2005年5月31日。 短期的不良反应包括转入血透、死亡、超出计划治疗期的持续性感染以及感染复发，长期的不良反应包括随之发生的腹膜炎或者死亡。经过对组间年龄、性别、糖尿病病史、肾脏代替治疗时程和病源器官等因素的平衡，具有高水平CRP的患者在诊断腹膜炎后，发生短期不良反应的可能性更大（二、三、四分位OR值分别为1.57, 2.73, 3.38 95%可信区间分别为为0.61–4.02, 1.09–6.87, 1.36–8.42,并且四分位数最高。）在符合腹膜炎标准并在诊断后经三周治疗的患者中，那些具有高水平CRP的患者长期不良反应的风险更大（风险率为1.79，95%可信区间CI 1.05–3.07）.总结，高水平CRP是腹透相关性腹膜炎的不良反应的独立相关因素。在腹透相关性腹膜炎期间对这一标志物的检测可能有助于更早期的识别有更高风险的并发症 我的翻译很不准确,谢谢njzjd08君的指正,我会继续努力,也希望njzjd08君有时间继续帮助指正,非常感谢! 请njzjd08战友将修改处对应原文、原译文一一贴出，以便他人清晰看出修改处。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-12-13 05:11
医学,生命科学网