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【商业翻译】H. Pylori Infection May Be Necessary for Mo
本稿件为《医师报》约稿，署名统一为“丁香”，稿酬按照医师报标准发放。
NEW YORK (Reuters Health) Apr 19 - A prospective study reported in the April issue of the American Journal of Gastroenterology found that gastric adenocarcinoma and gastric lymphoma developed only in patients infected with Helicobacter pylori, suggesting that "H. Pylori infection is a necessary cause of most gastric malignancies."
"Stomach cancer is the second leading cause of cancer death worldwide, killing upwards of one million people each year," Dr. Hui-Chun Chen, of Chang Gung University, Kaohsiung, Taiwan, and colleagues write.
The researchers examined the impact of H. pylori infection on the development of various gastric malignancies in Taiwan, in a total of 1225 dyspeptic patients who were followed-up for a mean of 6.3 years. Of the 1225 patients, 618 (50.4%) had H. pylori infection and 607 (49.6%) were not infected. Endoscopy was performed at enrollment and at 1- to 3-year intervals thereafter.
Gastric adenocarcinoma developed in seven of the H. pylori-infected participants and in none of the uninfected subjects during follow-up, while one of the H. pylori-infected patients and none of the uninfected patients developed gastric lymphoma. Taken together, patients infected with H. pylori had a significantly higher rate of gastric malignancy than uninfected patients (1.3% versus 0.0%, respectively; p = 0.007), the investigators report.
H. pylori eradication was achieved in 283 patients. Five patients in the eradication subgroup and two in the non-eradication subgroup developed gastric adenocarcinoma -- a nonsignificant difference.
The team found that only intestinal metaplasia was an independent factor predicting subsequent development of gastric malignancy, with an odds ratio of 4.5. "Follow-up for H. pylori-infected patients who have intestinal metaplasia is indicated," they conclude.
Am J Gastroenterol 2007;102:725-730. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 NEW YORK (Reuters Health) Apr 19 - A prospective study reported in the April issue of the American Journal of Gastroenterology found that gastric adenocarcinoma and gastric lymphoma developed only in patients infected with Helicobacter pylori, suggesting that "H. Pylori infection is a necessary cause of most gastric malignancies."
纽约（路透社 健康版）4月19日，一项前瞻性研究发现，胃腺癌和胃淋巴瘤只发生在感染了幽门螺杆菌的病人身上，并提出大多数胃恶性肿瘤发生的重要诱因是幽门螺杆菌的感染，并发表在四月份的美国胃肠病学杂志上
"Stomach cancer is the second leading cause of cancer death worldwide, killing upwards of one million people each year," Dr. Hui-Chun Chen, of Chang Gung University, Kaohsiung, Taiwan, and colleagues write.
“胃癌是全球第二大癌症，每年有超过100万的人死于癌症。”Chang Gung大学Hui-Chun Chen博士及其同事这样写到。
The researchers examined the impact of H. pylori infection on the development of various gastric malignancies in Taiwan, in a total of 1225 dyspeptic patients who were followed-up for a mean of 6.3 years. Of the 1225 patients, 618 (50.4%) had H. pylori infection and 607 (49.6%) were not infected. Endoscopy was performed at enrollment and at 1- to 3-year intervals thereafter.
在台湾，该研究检测了幽门螺杆菌对多种癌症的发生的影响，对1225名胃病患者跟踪研究 ６．３年。在1225名患者中有618名（50.4%）感染了幽门螺杆菌，607名（49.6%）没有感染。对患者进行内窥镜检查，并在其后的一到三年跟踪检查。
Gastric adenocarcinoma developed in seven of the H. pylori-infected participants and in none of the uninfected subjects during follow-up, while one of the H. pylori-infected patients and none of the uninfected patients developed gastric lymphoma. Taken together, patients infected with H. pylori had a significantly higher rate of gastric malignancy than uninfected patients (1.3% versus 0.0%, respectively; p = 0.007), the investigators report.
研究人员报导,在跟踪研究中，有7名幽门螺杆菌的感染者患胃腺癌，非感染者无一例，并有1名幽门螺杆菌感染者患胃淋巴瘤，非感染者无一例。综上，感染幽门螺杆菌的患者患胃恶性肿瘤的几率要明显高于非感染者（分别是1.3%,0.0%, p=0.007）.
H. pylori eradication was achieved in 283 patients. Five patients in the eradication subgroup and two in the non-eradication subgroup developed gastric adenocarcinoma -- a nonsignificant difference.
283名患者体内的幽门螺杆菌被清除.菌被清除的一组中有5名患者患腺癌,在菌未被清除的一组中有两名患者患病,差别不大.
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作者:admin@医学,生命科学 2010-10-31 05:11
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