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【medical-news】餐后胰岛素分泌的减少决定2型糖尿
http://www.eje-online.org/cgi/content/abstract/155/4/615?maxtoshow=&HITS=&hits=&RESULTFORMAT=&fulltext=Diabetic+Ketoacidosis+&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&fdate=10/1/2006&resourcetype=HWCIT
原文标题和摘要
Decrement of postprandial insulin secretion determines the progressive nature of type-2 diabetes
Objective: Type-2 diabetes is a progressive disease. However, little is known about whether decreased fasting or postprandial pancreatic ß-cell responsiveness is more prominent with increased duration of diabetes. The aim of this study was to evaluate the relationship between insulin secretion both during fasting and 2 h postprandial, and the duration of diabetes in type-2 diabetic patients.
Design: Cross-sectional clinical investigation.
Methods: We conducted a meal tolerance test in 1466 type-2 diabetic patients and calculated fasting (M0) and postprandial (M1) ß-cell responsiveness.
Results: The fasting C-peptide, postprandial C-peptide, M0, and M1 values were lower, but HbA1c values were higher, in patients with diabetes duration > 10 years than those in other groups. There was no difference in the HbA1c levels according to the tertiles of their fasting C-peptide level. However, in a group of patients with highest postprandial C-peptide tertile, the HbA1c values were significantly lower than those in other groups. After adjustment of age, sex, and body mass index (BMI), the duration of diabetes was found to be negatively correlated with fasting C-peptide ( = –0.102), postprandial C-peptide ( = –0.356), M0 ( = –0.263), and M1 ( = –0.315; P < 0.01 respectively). After adjustment of age, sex, and BMI, HbA1c was found to be negatively correlated with postprandial C-peptide ( = –0.264), M0 ( = –0.379), and M1 ( = –0.522), however, positively correlated with fasting C-peptide ( = 0.105; P < 0.01 respectively). In stepwise multiple regression analysis, M0, M1, and homeostasis model assessment for insulin resistance (HOMA-IR) emerged as predictors of HbAlc after adjustment for age, sex, and BMI (R2 = 0.272, 0.080, and 0.056 respectively).
Conclusions: With increasing duration of diabetes, the decrease of postprandial insulin secretion is becoming more prominent, and postprandial ß-cell responsiveness may be a more important determinant for glycemic control than fasting ß-cell responsiveness. Decrement of postprandial insulin secretion determines the progressive nature of type-2 diabetes
餐后胰岛素分泌的减少决定2型糖尿病的进展
Objective: Type-2 diabetes is a progressive disease.
目标：2型糖尿病是一种进展性的疾病。
However, little is known about whether decreased fasting or postprandial pancreatic ß-cell responsiveness is more prominent with increased duration of diabetes .
可是，禁食或餐后的胰腺ß细胞反应的削弱是否与糖尿病持续时间有显著关系，人们对此尚是所知甚少。
The aim of this study was to evaluate the relationship between insulin secretion both during fasting and 2 h postprandial, and the duration of diabetes in type-2 diabetic patients.
本研究的目的在于揭示禁食以及餐后2小时的胰岛素分泌，与2型糖尿病患者糖尿病持续时间的关系。
Design: Cross-sectional clinical investigation.
设计：横断面临床调查
Methods: We conducted a meal tolerance test in 1466 type-2 diabetic patients and calculated fasting (M0) and postprandial ß-cell responsiveness.
方法：我们在1466名2型糖尿病患者中引导实施一个食物耐量测试，并评估禁食（M0）以及餐后（M1）ß细胞的反应。
Results: The fasting C-peptide , postprandial C-peptide, M0, and M1 values were lower, but HbA1c values were higher, in patients with diabetes duration > 10 years than those in other groups.
结果：患糖尿病超过10年的病人组与其它组相比较而言，其禁食C肽、餐后C肽、M0、M1的水平都比较低，而糖化血红蛋白水平比较高。
There was no difference in the HbA1c levels according to the tertiles of their fasting C-peptide level.
而在按照禁食C肽水平高低分级的各组，其糖化血红蛋白水平没有什么区别。
However, in a group of patients with highest postprandial C-peptide tertile, the HbA1c values were significantly lower than those in other groups.
然而，在餐后C肽水平最高的病人组，所测糖化血红蛋白水平却显著低于其他组。
After adjustment of age, sex, and body mass index (BMI), the duration of diabetes was found to be negatively correlated with fasting C-peptide ( = –0.102), postprandial C-peptide ( = –0.356), M0 ( = –0.263), and M1 ( = –0.315; P < 0.01 respectively).
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作者:admin@医学,生命科学 2010-10-26 05:11
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