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【medical-news】在混合性高脂血症小鼠模型中人类
Hypertriglyceridemia is an independent risk factor for coronary artery disease. Because apolipoprotein (Apo)A5 regulates plasma triglyceride levels, we investigated the impact of human ApoA5 on atherogenesis. The influence of hApoA5 transgenic expression was studied in the ApoE2 knock-in mouse model of mixed dyslipidemia. Our results demonstrate that hApoA5 lowers plasma triglyceride levels in Western diet–fed ApoE2 knock-in mice. Moreover, atherosclerotic lesion development was significantly decreased in the hApoA5 transgenic mice. Finally, pharmacologic activation of hApoA5 expression by the peroxisome proliferator-activated receptor- agonist fenofibrate resulted in an enhanced atheroprotection. These results identify an atheroprotective role of hApoA5 in a mouse model of mixed dyslipidemia.
Key Words: human apolipoprotein A5 • atherosclerosis • dyslipidemia • fibrates • mouse model
Circulation Research. 2008;103:450 Atheroprotective Effect of Human Apolipoprotein A5 in a Mouse Model of Mixed Dyslipidemia
在混合性高脂血症小鼠模型中人类载脂蛋白A5的抗粥样硬化保护作用 在混合性高脂血症小鼠模型中人类载脂蛋白A5的抗粥样硬化保护作用
高甘油三酸酯血症是冠脉疾病的独立风险因子。因为载脂蛋白(Apo)A5调节血浆甘油三酯水平，于是我们研究了人类ApoA5在动脉粥样化形成中的影响。hApoA5转基因表达在ApoE2敲除后的混合型高脂血症大鼠中模型中进行研究。我们的结果证实hApoA5降低了Western食物喂养的，剔除ApoE2的大鼠血浆甘油三酯水平。还有，在hApoA5转基因老鼠中减缓粥样硬化病变的形成。最后，通过过氧化物酶体增生物激活受体激动剂非诺贝特药理学激活hApoA5的表达有抗粥样硬化保护作用。这些结果确定了hApoA5在混合性高脂血症小鼠模型中的作用。
关键词 人类载脂蛋白A5 动脉粥样硬化 血脂障碍 氯贝特 小鼠模型 不错！
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作者:admin@医学,生命科学 2010-10-16 05:11
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