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【medical-news】由肥胖与炎症之间的联系而引出的
Link Between Obesity And Inflammation Could Lead To New Therapies
Research conducted at the Methodist DeBakey Heart Center in Houston identifies a molecular link between obesity and inflammation that could lead to new therapies to prevent diabetes and heart disease.
Research presented this week at the American Heart Association Scientific Sessions shows that a high fat diet draws inflammatory cells into fat tissue, which prevents the tissue from storing the fats we eat. When the tissue can not store these fats, they end up in the liver and muscle, which in turn causes diabetes and heart disease.
"Understanding this link between obesity, diet and inflammation, may help us preventdiabetes and heart disease by tailoring new therapies to block the inflammation that initiates the destructive process," said Dr. Christie Ballantyne, cardiologist at the Methodist DeBakey Heart Center and principal investigator for the research.
Research presented today shows that a high fat diet leads fat cells to produce molecules called chemokines, which attract inflammatory white blood cells into fat tissue. Both macrophages and T cells , which play a critical role in the immune system, accumulate in fat tissue, beginning the process that leads to disease.
"The results of these studies provide additional evidence that new therapies which block the initial inflammation in fat tissue may help prevent or treat disorders related to obesity such as diabetes and heart disease," Ballantyne said.
This research was funded jointly by the American Diabetes Association and a grant from the Methodist DeBakey Heart Center.
For more information on the Methodist DeBakey Heart Center, see http://www.debakeyheartcenter.com.
Study detail
Obesity is associated with chronic inflammation, evidenced by elevated cytokine and chemokine expression and increased macrophage accumulation in adipose (fat) tissue (AT). T cells also play an important role in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity. The study hypothesized that elevated chemokines levels in AT in obesity are also associated with increased T cell accumulation.
Using flow cytometry, the study examined T cells in stromal/vascular cells from AT of diet-induced obese mice, which were C57BL/6 fed western high-fat diet 24 wk.
Compared to lean controls on standard chow diet, obese male mice but not obese females had significantly increased T cell number in AT (CD3+ cells: 3.5?0.4 x105/g tissue in obese males vs 1.5 ? 0.2 x105/g tissue in leans, P<0.01, n=5/group). mRNA levels of MCP-1, RANTES, and their receptors, CCR2 and CCR5, were upregulated in AT of obese males as examined by RNase protection assay (relative intensity to GAPDH and L32: MCP-1, 689?63 vs 188?6 in lean, P<0.01; RANTES, 558?84 vs 171?18, P<0.05; CCR2, 137?8 vs 63?4, P<0.01; CCR5, 135?13 vs 34?1, P<0.01; n=4/group).
AT from obese males also secreted higher levels of MCP-1 and RANTES than AT from lean controls when cultured ex vivo for 8 hr (MCP-1, 247?28 vs 133?14 ng/g tissue in lean, P<0.05; RANTES, 1716?133 vs 537?101 pg/g tissue in lean, P<0.01; n=4/group).
In vitro chemotaxis study showed that conditioned culture medium from AT of obese males induced significantly more T cell transmigration than AT of lean controls (448?90 vs 104?22 in lean, P<0.05, n=3/group).
Antibody neutralization of RANTES or MCP-1 markedly inhibited T cell transmigration induced by conditioned medium from AT of obese males (RANTES, inhibition 51?8%, P<0.05; MCP-1, inhibition 74?4%, P<0.05; n=3). In addition, mRNA levels of MCP-1, RANTES, CCR2 and CCR5 were increased in visceral AT compared to subcutaneous AT from morbidly obese humans. 本战友已经认领，如果48小时未交稿，其他战友可以继续 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Link Between Obesity And Inflammation Could Lead To New Therapies
由肥胖和炎症的联系可能产生新疗法
Research conducted at the Methodist DeBakey Heart Center in Houston identifies a molecular link between obesity and inflammation that could lead to new therapies to prevent diabetes and heart disease.
由美国休斯顿Methodist DeBakey心脏中心进行的研究发现了肥胖与炎症之间的分子机理有联系，从而可能产生预防糖尿病和心脏病的新疗法。
Research presented this week at the American Heart Association Scientific Sessions shows that a high fat diet draws inflammatory cells into fat tissue, which prevents the tissue from storing the fats we eat. When the tissue can not store these fats, they end up in the liver and muscle, which in turn causes diabetes and heart disease.
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作者:admin@医学,生命科学 2010-10-05 17:11
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